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Chiung-Kuei Huang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

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Soo Ok Lee George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

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Eugene Chang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
Department of Medicine, Case Cardiovascular Institute Research Institute, Case Western Reserve University, Cleveland, OH, USA

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Haiyan Pang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

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Chawnshang Chang George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
Sex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan

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and androgens, are two key factors that have been studied extensively ( Simon 2001 ). Postmenopausal women have decreased estrogen levels, and the decline of female hormone has been linked to elevated risk of CVDs in women for years; yet, some clinical

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Hen Prizant Division of Endocrinology and Metabolism, Center for Human Reproduction, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, PO Box 693, Rochester, New York 14642, USA

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Norbert Gleicher Division of Endocrinology and Metabolism, Center for Human Reproduction, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, PO Box 693, Rochester, New York 14642, USA

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Aritro Sen Division of Endocrinology and Metabolism, Center for Human Reproduction, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, PO Box 693, Rochester, New York 14642, USA
Division of Endocrinology and Metabolism, Center for Human Reproduction, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, PO Box 693, Rochester, New York 14642, USA

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Introduction Recently, there has been a lot of interest towards the role of androgens in the regulation of follicular development and female fertility. In fact, over the years our understanding of the effects of androgens on follicular development

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Rebecca J Ainslie Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Ioannis Simitsidellis Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Phoebe M Kirkwood Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Douglas A Gibson Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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androgens, control immune cell function in the womb and how this might affect women’s reproductive health. His lab uses fate-mapping techniques, transcriptomics analysis, multiparameter flow cytometry and immunohistochemistry to characterise the phenotype

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K A Walters School of Women’s & Children’s Health, University of New South Wales, Sydney, New South Wales, Australia
Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia

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V Rodriguez Paris School of Women’s & Children’s Health, University of New South Wales, Sydney, New South Wales, Australia

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A Aflatounian School of Women’s & Children’s Health, University of New South Wales, Sydney, New South Wales, Australia

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D J Handelsman Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia

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Introduction Androgens are sex steroid hormones that are well known to be crucial for male sexual and reproductive function. In females, androgens play an essential role in ovarian follicular development as testosterone is the obligatory

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Hongjuan Shi Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Tian Gao Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Zhilong Liu Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Lina Sun Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Xiaolong Jiang Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Lili Chen Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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Deshou Wang Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, People’s Republic of China

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, the main androgen in most teleosts) synthesis, started to get expressed in Leydig cells of the testis, and consequently, the androgen level was significantly upregulated in teleost ( Borg 1994 , Kobayashi et al . 1998 , Nakamura et al . 1998

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Patricia K Russell Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Salvatore Mangiafico Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Barbara C Fam Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Michele V Clarke Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Evelyn S Marin Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Sofianos Andrikopoulos Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Kristine M Wiren Research Service, Veterans Affairs Medical Center, Portland, Oregon, USA
Departments of Medicine and Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA

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Jeffrey D Zajac Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Rachel A Davey Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

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Introduction There are abundant data that fat mass is negatively regulated by androgens in men. Hypogonadal men with low serum testosterone levels have increased visceral obesity compared to men with normal serum testosterone ( Bhasin et al

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Diego Crespo Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands

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Moline Severino Lemos Laboratory of Cell Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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Yu Ting Zhang State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Fujian, People’s Republic of China
Institute of Oceanography, Minjiang University, Fuzhou, People’s Republic of China

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Diego Safian Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands

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Birgitta Norberg Institute of Marine Research, Austevoll Research Station, Storebø, Norway

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Jan Bogerd Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands

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Rüdiger W Schulz Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands
Research Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway

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al. 1975 , 1976 ) and dog ( Moskovitz et al. 1987 )). Later studies in rat suggested that part of these effects reflect PG-mediated modulation of Leydig cell steroidogenesis, considering that PDG 2 -promoted while PGF 2α suppressed androgen

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Xiaonan Yan State Key Laboratory of Reproductive Medicine, Xuzhou Medical College, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China
State Key Laboratory of Reproductive Medicine, Xuzhou Medical College, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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Chun Yuan State Key Laboratory of Reproductive Medicine, Xuzhou Medical College, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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Nannan Zhao State Key Laboratory of Reproductive Medicine, Xuzhou Medical College, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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Yugui Cui State Key Laboratory of Reproductive Medicine, Xuzhou Medical College, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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Jiayin Liu State Key Laboratory of Reproductive Medicine, Xuzhou Medical College, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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, experimental, and genetic evidence supports the hypothesis that prenatal exposure to excessive maternal androgens induces the PCOS-related phenotype in female offspring ( Xita & Tsatsoulis 2006 , Forsdike et al . 2007 , Abbott et al . 2009 , Roland et al

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Ioannis Simitsidellis Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Arantza Esnal-Zuffiaure Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Olympia Kelepouri Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Elisabeth O’Flaherty Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Douglas A Gibson Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Philippa T K Saunders Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Introduction Androgens are pleiotropic hormones which bind with high affinity and specificity to androgen receptors (ARs) to regulate both reproductive and other tissues. In the uterus, androgen-target cells include stromal fibroblasts and

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Hong-Yo Kang Graduate Institute of Clinical Medical Sciences, Hormone Research Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan

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Testosterone – the primary form of androgen – is synthesized mainly in the gonads and secreted into the bloodstream where it can circulate and exert a number of diverse effects in peripheral target tissues at various locations. After entering the

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