Filter

Refine by date

—

Refine by collections

Refine by access

  • Print
  • Save

Search Results

You are looking at 1 - 10 of 714 items for :

  • Refine by access: All content x
Clear All
R Paul Robertson Nutrition Department of Internal Medicine, Division of Metabolism Endocrinology, University of Washington, Seattle, Washington, USA

Search for other papers by R Paul Robertson in
Google Scholar
PubMed Close

Introduction The editors asked that I write a brief introductory article for this special collection, which focuses on scientific advances in glucagon research and its clinical impacts. In doing so, I will provide a short history of glucagon

Article Type:
Review Article
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0224
Volume/Issue:
Volume 258: Issue 2
Free access
Jennifer H Stern Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

Search for other papers by Jennifer H Stern in
Google Scholar
PubMed Close
,
Gordon I Smith Center for Human Nutrition, Washington University School of Medicine, Saint Louis, Missouri, USA

Search for other papers by Gordon I Smith in
Google Scholar
PubMed Close
,
Shiuwei Chen Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

Search for other papers by Shiuwei Chen in
Google Scholar
PubMed Close
,
Roger H Unger Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

Search for other papers by Roger H Unger in
Google Scholar
PubMed Close
,
Samuel Klein Center for Human Nutrition, Washington University School of Medicine, Saint Louis, Missouri, USA

Search for other papers by Samuel Klein in
Google Scholar
PubMed Close
, and
Philipp E Scherer Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

Search for other papers by Philipp E Scherer in
Google Scholar
PubMed Close

a major focus of metabolic research in obesity, glucagon is also an important regulator of glycemic control. In fact, Orci and Unger’s ‘bihormonal hypothesis’ (1975) ( Unger & Orci 1975 ) prompted decades of work that created abundant evidence

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0201
Volume/Issue:
Volume 243: Issue 2
Restricted access
Wanbao Yang Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by Wanbao Yang in
Google Scholar
PubMed Close
,
Hui Yan Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by Hui Yan in
Google Scholar
PubMed Close
,
Quan Pan Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by Quan Pan in
Google Scholar
PubMed Close
,
James Zheng Shen Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by James Zheng Shen in
Google Scholar
PubMed Close
,
Fenghua Zhou Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by Fenghua Zhou in
Google Scholar
PubMed Close
,
Chaodong Wu Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by Chaodong Wu in
Google Scholar
PubMed Close
,
Yuxiang Sun Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by Yuxiang Sun in
Google Scholar
PubMed Close
, and
Shaodong Guo Department of Nutrition and Food Science, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas, USA

Search for other papers by Shaodong Guo in
Google Scholar
PubMed Close

Introduction Glucagon secreted from the α-cells of pancreatic islets is a predominant counter regulatory hormone to the action of insulin in control of blood glucose homeostasis ( Habegger et al. 2010 ). This 29 animo acid peptide hormone is

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0081
Volume/Issue:
Volume 241: Issue 3
Free access
Jasleen Kaur Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA

Search for other papers by Jasleen Kaur in
Google Scholar
PubMed Close
and
Elizabeth R Seaquist Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA

Search for other papers by Elizabeth R Seaquist in
Google Scholar
PubMed Close

Introduction Glucagon is a 29 amino acid pancreatic peptide hormone secreted by the pancreatic alpha cells. It is derived from the precursor hormone proglucagon, which is also a precursor for glucagon-like gut peptides ( Sandoval & D

Article Type:
Review Article
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0278
Volume/Issue:
Volume 257: Issue 1
Free access
Rui Gao Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

Search for other papers by Rui Gao in
Google Scholar
PubMed Close
,
Samuel Acreman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden

Search for other papers by Samuel Acreman in
Google Scholar
PubMed Close
,
Jinfang Ma Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

Search for other papers by Jinfang Ma in
Google Scholar
PubMed Close
,
Fernando Abdulkader Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

Search for other papers by Fernando Abdulkader in
Google Scholar
PubMed Close
,
Anna Wendt Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden

Search for other papers by Anna Wendt in
Google Scholar
PubMed Close
, and
Quan Zhang Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal

Search for other papers by Quan Zhang in
Google Scholar
PubMed Close

Introduction In the body, blood glucose levels are kept within a narrow range by concerted action of glucagon and insulin, the glucose-regulating hormones secreted by α- and β-cells, respectively ( Göke 2008 ). Whereas the islet α-cells were

Article Type:
Review Article
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0295
Volume/Issue:
Volume 258: Issue 2
Open access
James Cantley Division of Systems Medicine, School of Medicine, University of Dundee, UK

Search for other papers by James Cantley in
Google Scholar
PubMed Close
,
Vincent Poitout Montreal Diabetes Research Center, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Department of Medicine, Université de Montréal, Montréal, QC, Canada

Search for other papers by Vincent Poitout in
Google Scholar
PubMed Close
, and
Rebecca L Hull-Meichle Research and Development Service, VA Puget Sound Health Care System, Seattle, Washington, USA
Department of Medicine, University of Washington, Seattle, Washington, USA

Search for other papers by Rebecca L Hull-Meichle in
Google Scholar
PubMed Close

Glucagon, the principal hormone produced by pancreatic islet alpha (α) cells, has a range of profound effects on metabolism including, but not limited to, stimulation of hepatic glucose production. Accordingly, glucagon has been utilised as a

Article Type:
Editorial
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-23-0138
Volume/Issue:
Volume 258: Issue 3
Free access
Hans Eickhoff Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal
Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal

Search for other papers by Hans Eickhoff in
Google Scholar
PubMed Close
,
Teresa Louro Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal
Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal

Search for other papers by Teresa Louro in
Google Scholar
PubMed Close
,
Paulo Matafome Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal
Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal

Search for other papers by Paulo Matafome in
Google Scholar
PubMed Close
,
Raquel Seiça Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal
Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal

Search for other papers by Raquel Seiça in
Google Scholar
PubMed Close
, and
Francisco Castro e Sousa Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal
Obesity Center, Faculty of Medicine, Biomedical Imaging and Life Sciences (IBILI), Department of Surgery A, Faculty of Medicine, Hospital de Santiago, EN 10, km 37, 2900‐722 Setubal, Portugal

Search for other papers by Francisco Castro e Sousa in
Google Scholar
PubMed Close

-dependent insulinotropic peptide (GIP) and reduced glucagon-like peptide 1 (GLP1) secretion seem to play an additional role in the development of type 2 diabetes ( Holst et al . 2009 ). Excessive or inadequate glucagon secretion promoting hepatic gluconeogenesis and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0445
Volume/Issue:
Volume 223: Issue 3
Free access
Emma Rose McGlone Department of Surgery and Cancer, Imperial College London, London, UK

Search for other papers by Emma Rose McGlone in
Google Scholar
PubMed Close
,
Stephen R Bloom Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

Search for other papers by Stephen R Bloom in
Google Scholar
PubMed Close
, and
Tricia M-M Tan Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

Search for other papers by Tricia M-M Tan in
Google Scholar
PubMed Close

Introduction Glucagon is a peptide hormone secreted by alpha cells in the pancreas which acts on several organs including the liver, kidney, heart and brain ( Marroqui et al. 2014 , Wewer Albrechtsen et al. 2023 ). The precursor protein

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0365
Volume/Issue:
Volume 261: Issue 3
Open access
Mingyu Li Departments of Molecular Physiology and Biophysics, Division of Diabetes, Third Institute of Oceanography, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Light Hall, Room 711, 2215 Garland Avenue, Nashville, Tennessee 37232, USA

Search for other papers by Mingyu Li in
Google Scholar
PubMed Close
,
E Danielle Dean Departments of Molecular Physiology and Biophysics, Division of Diabetes, Third Institute of Oceanography, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Light Hall, Room 711, 2215 Garland Avenue, Nashville, Tennessee 37232, USA

Search for other papers by E Danielle Dean in
Google Scholar
PubMed Close
,
Liyuan Zhao Departments of Molecular Physiology and Biophysics, Division of Diabetes, Third Institute of Oceanography, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Light Hall, Room 711, 2215 Garland Avenue, Nashville, Tennessee 37232, USA
Departments of Molecular Physiology and Biophysics, Division of Diabetes, Third Institute of Oceanography, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Light Hall, Room 711, 2215 Garland Avenue, Nashville, Tennessee 37232, USA

Search for other papers by Liyuan Zhao in
Google Scholar
PubMed Close
,
Wendell E Nicholson Departments of Molecular Physiology and Biophysics, Division of Diabetes, Third Institute of Oceanography, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Light Hall, Room 711, 2215 Garland Avenue, Nashville, Tennessee 37232, USA

Search for other papers by Wendell E Nicholson in
Google Scholar
PubMed Close
,
Alvin C Powers Departments of Molecular Physiology and Biophysics, Division of Diabetes, Third Institute of Oceanography, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Light Hall, Room 711, 2215 Garland Avenue, Nashville, Tennessee 37232, USA
Departments of Molecular Physiology and Biophysics, Division of Diabetes, Third Institute of Oceanography, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Light Hall, Room 711, 2215 Garland Avenue, Nashville, Tennessee 37232, USA
Departments of Molecular Physiology and Biophysics, Division of Diabetes, Third Institute of Oceanography, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Light Hall, Room 711, 2215 Garland Avenue, Nashville, Tennessee 37232, USA

Search for other papers by Alvin C Powers in
Google Scholar
PubMed Close
, and
Wenbiao Chen Departments of Molecular Physiology and Biophysics, Division of Diabetes, Third Institute of Oceanography, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Light Hall, Room 711, 2215 Garland Avenue, Nashville, Tennessee 37232, USA

Search for other papers by Wenbiao Chen in
Google Scholar
PubMed Close

Introduction Glucagon is a peptide hormone secreted by pancreatic α-cells. It is the main counter-regulatory hormone of insulin. Glucagon acts primarily on liver through glucagon receptor (GCGR) to regulate hepatic glucose production ( Mayo et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0284
Volume/Issue:
Volume 227: Issue 2
Free access
Michael Merkhassine Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA
VCA Colonial Animal Hospital, Ithaca, New York, USA

Search for other papers by Michael Merkhassine in
Google Scholar
PubMed Close
,
Reilly W Coch Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA
Weill Cornell College of Medicine, New York, New York, USA

Search for other papers by Reilly W Coch in
Google Scholar
PubMed Close
,
Carol E Frederick Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

Search for other papers by Carol E Frederick in
Google Scholar
PubMed Close
,
Lucinda L Bennett Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

Search for other papers by Lucinda L Bennett in
Google Scholar
PubMed Close
,
Seth A Peng Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA
Fate Therapeutics, San Diego, California, USA

Search for other papers by Seth A Peng in
Google Scholar
PubMed Close
,
Benjamin Morse Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

Search for other papers by Benjamin Morse in
Google Scholar
PubMed Close
,
Bethany P Cummings Center for Alimentary and Metabolic Science, Department of Surgery, School of Medicine, University of California, Davis, Sacramento, California, USA
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA

Search for other papers by Bethany P Cummings in
Google Scholar
PubMed Close
, and
John P Loftus Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

Search for other papers by John P Loftus in
Google Scholar
PubMed Close

Introduction Glucagon is a pancreatic endocrine hormone involved in regulating circulating glucose and amino acid (AA) levels and is an important therapeutic target for various metabolic and gastrointestinal conditions ( Unger & Cherrington

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0051
Volume/Issue:
Volume 262: Issue 2
Open access