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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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. 2023 ) and parathyroid hormone ( van der Lee et al. 2013 , Liu et al. 2019 , Pena et al. 2022 ) receptors are also drug targets whose biased activation has been studied to disentangle therapeutic and off-target signaling pathways and might