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Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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discuss the plethora of evidence demonstrating that ACE2 drives COVID-19 age, sex, and pregnancy-associated vulnerabilities and the culminating need for greater understanding of ACE2 and its pathophysiological role. The objective of this narrative review

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Adam Hagg School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Eliza O’Shea School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Craig A Harrison Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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Kelly L Walton School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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progeny despite high ovulation rates ( Brule et al. 2021 ). Pregnancy and neonatal loss in mice lacking inhibin A/B bioactivity or responsiveness are likely attributed to altered ovarian hormone milieu, as the ovaries in inhibin-inactivated pregnant dams

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Chau Thien Tay Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia

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Rhonda Garrad Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia

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Aya Mousa Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia

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Mahnaz Bahri Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia

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Anju Joham Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia

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Helena Teede Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia

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), reproductive (anovulation, subfertility, pregnancy complications), dermatological (acne, hirsutism, alopecia) and psychological (depression, anxiety, eating disorders, impaired quality of life) sequelae ( Lim et al. 2012 , 2019 , Joham et al. 2015

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Sunita M C De Sousa Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

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Nèle F Lenders Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia

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Lydia S Lamb Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia

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Warrick J Inder Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Australia
Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia

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Ann McCormack Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia

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familial pituitary tumours allows personalised PA management, gene-specific tumour surveillance, cascade testing of at-risk relatives and tailored reproductive advice with respect to PA management around pregnancy and risk to offspring. Gene

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