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In vivo models of gestational and type 2 diabetes mellitus characterized by endocrine pancreas cell impairments

Sandra K Szlapinski

Sandra K Szlapinski London, Ontario, Canada

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David J Hill

David J Hill Diabetes, Endocrinology and Metabolism, Lawson Health Research Institute, London, Ontario, Canada
Physiology and Pharmacology, Western University, London, Ontario, Canada

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developmental programming that occurs following exposure to suboptimal in utero conditions. While the predominant concern for the fetus in pregnancies complicated by GDM is macrosomia, intrauterine growth restriction can also occur ( Moon & Jang 2022

Article Type:: Review Article

Collections:: Insulin resistance and type 2 diabetes mellitus

DOI:: https://doi.org/10.1530/JOE-23-0317

Volume/Issue:: Volume 260: Issue 3

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Role of CD20⁺ T cells in cancer, autoimmunity and obesity

Aryane Cruz Oliveira Pinho

Aryane Cruz Oliveira Pinho CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

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Paula Laranjeira

Paula Laranjeira CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Flow Cytometry Unit, Department of Clinical Pathology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal
Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal

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Eugenia Carvalho

Eugenia Carvalho CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Institute for Interdisciplinary Research, University of Coimbra (IIIUC), Casa Costa Alemão, Coimbra, Portugal
APDP-Portuguese Diabetes Association, Lisbon, Portugal

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, repetitive antigen stimulation), which may induce dysregulation in the process of CD20 + T cell activation and/or cytokine and chemokine secretion, and finally, activate the program of exhaustion within the AT microenvironment. In this context, and since a

Article Type:: Review Article

Collections:: Insulin resistance and type 2 diabetes mellitus

DOI:: https://doi.org/10.1530/JOE-23-0242

Volume/Issue:: Volume 260: Issue 3

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In vivo techniques for assessment of insulin sensitivity and glucose metabolism

Margaret K Hahn

Margaret K Hahn Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada

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Adria Giacca

Adria Giacca Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Sandra Pereira

Sandra Pereira Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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AO Santos LR Sollon CS Gomes PR Faria JA , et al. 2012 Maternal melatonin programs the daily pattern of energy metabolism in adult offspring . PLoS One 7 e38795 . ( https://doi.org/10.1371/journal.pone.0038795 ) Frangioudakis G Gyte AC