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Sandra K Szlapinski London, Ontario, Canada

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David J Hill Diabetes, Endocrinology and Metabolism, Lawson Health Research Institute, London, Ontario, Canada
Physiology and Pharmacology, Western University, London, Ontario, Canada

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. 2018 ). The metabolic phenotype resulting from an HFD varies considerably with the strain of mouse or rat. For mouse, the C57BL/6 strain has been shown to be most sensitive to diet-induced obesity, with insulin resistance and postprandial hyperglycemia

Article Type:
Review Article
Collections:
Insulin resistance and type 2 diabetes mellitus
DOI:
https://doi.org/10.1530/JOE-23-0317
Volume/Issue:
Volume 260: Issue 3
Restricted access
Margaret K Hahn Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada

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Adria Giacca Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Sandra Pereira Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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glucose concentrations (i.e. euglycemia); this requires frequent blood sampling and measuring of plasma glucose ( Fig. 1B , which is based on ( DeFronzo et al. 1979 , Pereira et al. 2013 )). A rat’s own red blood cells are reinfused i.v. throughout

Article Type:
Review Article
Collections:
Insulin resistance and type 2 diabetes mellitus
DOI:
https://doi.org/10.1530/JOE-23-0308
Volume/Issue:
Volume 260: Issue 3
Open access