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M Fraenkel Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

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J Caloyeras Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

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S-G Ren Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

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S Melmed Cedars-Sinai Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, California 90048, USA

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. 1978 , Maclaren et al. 1980 , Kava et al. 1992 , Shi et al. 1994 , Weksler-Zangen et al. 2001 ). Removal of testosterone from the sex-steroid milieu of the male animal improved insulin sensitivity in most studies, and thus was protective

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06656
Volume/Issue:
Volume 189: Issue 3
Free access
Ángel Enrique Céspedes Rubio Departamento de Sanidad Animal, Grupo de Investigación en Enfermedades Neurodegenerativas, Universidad del Tolima, Ibagué, Colombia

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Maria José Pérez-Alvarez Departamento de Biología (Fisiología Animal), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Departamento de Neuropatología Molecular CSIC-UAM, Madrid, Spain
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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Catalina Lapuente Chala Grupo de Investigación en Enfermedades Neurodegenerativas, Investigador Asociado Universidad del Tolima, Ibagué, Colombia

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Francisco Wandosell Centro de Biología Molecular ‘Severo Ochoa’, Departamento de Neuropatología Molecular CSIC-UAM, Madrid, Spain
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

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activates c-Src family tyrosine kinases . Molecular Cell 8 269 – 280 . ( https://doi.org/10.1016/S1097-2765(01)00304-5 ) 10.1016/S1097-2765(01)00304-5 11545730 Bourque M Dluzen DE Di Paolo T 2009 Neuroprotective actions of sex steroids in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0129
Volume/Issue:
Volume 237: Issue 2
Free access
Lachlan J Pearson Department of Obstetrics and Gynaecology and
Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand

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Christopher Rait Department of Obstetrics and Gynaecology and
Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand

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M Gary Nicholls Department of Obstetrics and Gynaecology and
Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand

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Timothy G Yandle Department of Obstetrics and Gynaecology and
Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand

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John J Evans Department of Obstetrics and Gynaecology and
Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand

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peptide and the sex steroid increased the number of cells that secreted adrenomedullin, both hormones induced an increase in the mean level of expression of adrenomedullin mRNA (Fig. 5 ), the effect being statistically significant for testosterone

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06815
Volume/Issue:
Volume 191: Issue 1
Free access
Filip Callewaert Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Mieke Sinnesael Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Evelien Gielen Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Steven Boonen Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Dirk Vanderschueren Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Introduction Sex steroids are mainly synthesized by the gonads (testis and ovary), but the adrenals constitute an additional source ( Vanderschueren et al . 2004 , Callewaert et al . 2010 a ). Sex steroids are involved in the regulation of a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0209
Volume/Issue:
Volume 207: Issue 2
Free access
Taija Saloniemi Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland

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Heli Jokela Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland

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Leena Strauss Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland
Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland

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Pirjo Pakarinen Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland
Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland

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Matti Poutanen Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland
Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland

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Introduction Imbalanced action of sex steroid hormones, i.e. androgens and estrogens, is involved in the pathogenesis of various severe diseases in humans. Hormone-dependent cancers are commonly lethal both in women and in men, with breast cancer

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0315
Volume/Issue:
Volume 212: Issue 1
Free access
Alexia Barroso Department of Cell Biology, Physiology, and Immunology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain
CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain

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Jose Antonio Santos-Marcos CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain

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Cecilia Perdices-Lopez Department of Cell Biology, Physiology, and Immunology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain
CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain

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Ana Vega-Rojas CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain

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Miguel Angel Sanchez-Garrido Department of Cell Biology, Physiology, and Immunology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain
CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain

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Yelizabeta Krylova CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain

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Helena Molina-Abril Department of Applied Mathematics I, University of Seville, Seville, Spain

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Claes Ohlsson Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Pablo Perez-Martinez CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain

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Matti Poutanen Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland

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Jose Lopez-Miranda CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain

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Manuel Tena-Sempere Department of Cell Biology, Physiology, and Immunology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain
CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland

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Antonio Camargo CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain

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Introduction Sex steroids are key metabolic regulators in different tissues, with proven roles in the control of food intake and energy homeostasis, whose deregulation is frequently linked to the manifestation of diseases ( Mauvais-Jarvis et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0277
Volume/Issue:
Volume 247: Issue 1
Restricted access
Maria Konstandi Department of Pharmacology, University of Ioannina, School of Health Sciences, Faculty of Medicine, Ioannina, Greece
National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA

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Christina E Andriopoulou Department of Pharmacology, University of Ioannina, School of Health Sciences, Faculty of Medicine, Ioannina, Greece

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Jie Cheng National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA

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Frank J Gonzalez National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA

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to direct hormonal regulation and were known as ‘un-inducible’ CYPs ( Daskalopoulos et al . 2012 b ). However, previous studies showed that sex steroid hormones affect the expression of CYP2D in the rat brain. In particular, testosterone treatment

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0561
Volume/Issue:
Volume 245: Issue 2
Restricted access
Cristina Aresté
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M Jesús Melià
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Joan Isern
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José Luis Tovar
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Anna Meseguer
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important to understand the physiological function of this highly restricted tissue-specific gene to gain insight into the physiological effects of sexual steroids in the kidney. In this report, we further explored the tissue distribution and sex-steroid

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05649
Volume/Issue:
Volume 183: Issue 1
Free access
F Vilchis Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga no. 15, Del. Tlalpan C.P. 14000, México D.F., Mexico

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L Ramos Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga no. 15, Del. Tlalpan C.P. 14000, México D.F., Mexico

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C Timossi Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga no. 15, Del. Tlalpan C.P. 14000, México D.F., Mexico

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B Chávez Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga no. 15, Del. Tlalpan C.P. 14000, México D.F., Mexico

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enzymes whose activity is influenced by sex steroids ( Spike et al. 1992 , Gibson et al. 1999 , Coto-Montes et al. 2001 ). In fact, the female hamster has considerably more porphyrins than the male ( Spike et al. 1985 , 1986 ). These

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06300
Volume/Issue:
Volume 189: Issue 1
Free access
Timothy C R Prickett
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Graham K Barrell Department of Medicine, Agriculture & Life Sciences Division, University of Otago, PO Box 4345, Christchurch 8140, New Zealand

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Martin Wellby Department of Medicine, Agriculture & Life Sciences Division, University of Otago, PO Box 4345, Christchurch 8140, New Zealand

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Timothy G Yandle
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A Mark Richards
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Eric A Espiner
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clarified. It is well known that a variety of circulating hormones have the potential to affect linear growth and bone formation ( van der Eerden et al . 2003 ). For example, in humans sex steroids have important actions during puberty to enhance linear

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0267
Volume/Issue:
Volume 199: Issue 3
Free access