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triiodothyronine (T3) are initiated by binding to the nuclear thyroid hormone receptors (TRs), encoded by the TRα and TRβ genes, which result in several isoforms with different expression and functions ( Aranda & Pascual 2001 , Aranda et al . 2013 , Pascual
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, Mullur et al . 2014 , Mondal et al . 2016 , Mendoza & Hollenberg 2017 , van der Spek et al . 2017 ). Much of thyroid hormone action is mediated by the thyroid hormone receptors (TRs), members of the nuclear receptor superfamily that act as ligand
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decreased activity of liver D1 therefore contributes to low serum T 3 levels. TRβ1, one of the thyroid hormone receptors through which T 3 exerts its actions in the liver, is also downregulated in an animal model of NTI. This suggests that impaired T 3
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-affinity thyroid hormone receptor (TR) located in the nucleus. TR plays an important role in mediating the cardiac physiologic actions of T 3 ( Sussman 2001 , Dillmann 2002 ). Normal thyroid hormone level is essential for maintaining normal heart structure and
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( Castro et al. 2006 ). At variance with PTC, a mouse model for FTC was lacking until Kaneshige et al. (2000) described a mutant mouse with a mutation ( PV ) targeted to the thyroid hormone receptor β (THRB) locus. In a heterozygous condition
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Université Victor Segalen Bordeaux 2, Bordeaux, France
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. Journal of Bone and Mineral Research 11 105 –113. Amma LL , Campos-Barros A, Wang Z, Vennstrom B & Forrest D 2001 Distinct tissue-specific roles for thyroid hormone receptors beta and alpha1 in regulation of type 1
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-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chemistry and Biology 5 299 –306. Danzi S & Klein I 2004 Thyroid hormone and the cardiovascular system. Minerva Endocrinologica 29 139 –150
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XG Willingham MC Cheng SY 2009 Distinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms . Molecular Endocrinology 23 308 – 315 . ( doi:10.1210/me.2008-0311 ) Arnold S Goglia F Kadenbach B 1998 3
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. Table 1 Basal laboratory values of thyroid hormone receptor (TRβ −/− ) and wild-type (WT) mice. Mean values± s.e.m. are given Wild-type TRβ −/− ♀ ♂ ♀ ♂ Serum T 3 (nmol/l) 1.55±0.34 1.34±0.14 2.53±0.24* 2.68±0.21 † Serum T 4 (nmol/l) 67±6 57±4 133
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2015 Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor beta . Cancer Research 75 1265 – 1274 . ( doi:10.1158/0008-5472.CAN-14-1875 ) Alamino VA Montesinos MM