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these results to publicly available data on the genomic binding of several other islet-enriched transcription factors, in order to determine whether GLIS3 regulates pancreatic beta cell gene transcription by binding to distinct regulatory hubs with other

Part I: introduction to FOXO transcription factors Classification and structure of FOXO proteins FOXO transcription factors form a subclass of the large family of Forkhead proteins characterized by the

. Carbohydrate response element-binding protein (ChREBP) is one of the key transcription factors regulating DNL in liver and intestine ( Iizuka et al . 2004 , Kim et al . 2016 , 2017 , Liu et al . 2017 , Shi et al . 2020 ). Although ChREBP is also

orthologs of the Drosophila gene glial cells missing) is a transcription factor which is exclusively expressed during embryonic development in the parathyroid-specific domain that later gives rise to the parathyroid glands ( Kim et al . 1998 , Günther

( Kioussi et al . 1999 ), Tpit ( Lamolet et al . 2001 ) and Prop1 ( Sornson et al . 1996 ). Figure 2 Temporal and spatial activation of pituitary transcription factors. In response to the BMP2–FGF8 ventral–dorsal gradient, pituitary cell lineages are

Introduction Transcription factors (TFs) are central to almost every fundamental cellular process ( Latchman 2008 , Ladunga 2010 ) and account for ∼5–10% of genes in eukaryotes ( Reece-Hoyes et al . 2005 , Adryan & Teichmann 2006 , Ho et al

Introduction Transcription factors of the forkhead (FOXO) family of DNA-binding proteins are involved in regulation of diverse cellular functions, such as differentiation, metabolism, proliferation, and survival (for review see

of intense tissue remodelling. Among these factors are members of the FOXO family of transcription factors. FOXO proteins, functioning downstream of the phosphoinositol-3-kinase (PI3K)/AKT oncogenic signalling pathway, are central to a diversity of

Introduction The doublesex and mab-3 (DM)-related transcription factor 1 ( Dmrt1 ) belongs to the DM domain gene family. Among the different phyla of the animal kingdom including vertebrates, it is the only gene found to be conserved

pancreatic precursor cells into either acinar, islet or duct cells is apparent morphologically ( Slack 1995 ). The differentiation of these cells is regulated by the correct temporal and spatial expression of a series of transcription factors that direct