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David W Scoville, Kristin Lichti-Kaiser, Sara A Grimm, and Anton M Jetten

these results to publicly available data on the genomic binding of several other islet-enriched transcription factors, in order to determine whether GLIS3 regulates pancreatic beta cell gene transcription by binding to distinct regulatory hubs with other

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Dominique A Glauser and Werner Schlegel

Part I: introduction to FOXO transcription factors Classification and structure of FOXO proteins FOXO transcription factors form a subclass of the large family of Forkhead proteins characterized by the

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Chunchun Wei, Xianhua Ma, Kai Su, Shasha Qi, Yuangang Zhu, Junjian Lin, Chenxin Wang, Rui Yang, Xiaowei Chen, Weizhong Wang, and Weiping J Zhang

. Carbohydrate response element-binding protein (ChREBP) is one of the key transcription factors regulating DNL in liver and intestine ( Iizuka et al . 2004 , Kim et al . 2016 , 2017 , Liu et al . 2017 , Shi et al . 2020 ). Although ChREBP is also

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Michael Mannstadt, Emily Holick, Wenping Zhao, and Harald Jüppner

orthologs of the Drosophila gene glial cells missing) is a transcription factor which is exclusively expressed during embryonic development in the parathyroid-specific domain that later gives rise to the parathyroid glands ( Kim et al . 1998 , Günther

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Débora Cristina de Moraes, Mario Vaisman, Flavia Lucia Conceição, and Tânia Maria Ortiga-Carvalho

( Kioussi et al . 1999 ), Tpit ( Lamolet et al . 2001 ) and Prop1 ( Sornson et al . 1996 ). Figure 2 Temporal and spatial activation of pituitary transcription factors. In response to the BMP2–FGF8 ventral–dorsal gradient, pituitary cell lineages are

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Jinke Wang, Jie Lu, Guangming Gu, and Yingxun Liu

Introduction Transcription factors (TFs) are central to almost every fundamental cellular process ( Latchman 2008 , Ladunga 2010 ) and account for ∼5–10% of genes in eukaryotes ( Reece-Hoyes et al . 2005 , Adryan & Teichmann 2006 , Ho et al

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L Grinius, C Kessler, J Schroeder, and S Handwerger

Introduction Transcription factors of the forkhead (FOXO) family of DNA-binding proteins are involved in regulation of diverse cellular functions, such as differentiation, metabolism, proliferation, and survival (for review see

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Eric W-F Lam, Kunal Shah, and Jan J Brosens

of intense tissue remodelling. Among these factors are members of the FOXO family of transcription factors. FOXO proteins, functioning downstream of the phosphoinositol-3-kinase (PI3K)/AKT oncogenic signalling pathway, are central to a diversity of

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Zhihao Liu, Fengrui Wu, Baowei Jiao, Xiuyue Zhang, Chongjiang Hu, Baofeng Huang, Linyan Zhou, Xigui Huang, Zhijian Wang, Yaoguang Zhang, Yoshitaka Nagahama, Christopher H K Cheng, and Deshou Wang

Introduction The doublesex and mab-3 (DM)-related transcription factor 1 ( Dmrt1 ) belongs to the DM domain gene family. Among the different phyla of the animal kingdom including vertebrates, it is the only gene found to be conserved

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E N Fazio, M Everest, R Colman, R Wang, and C L Pin

pancreatic precursor cells into either acinar, islet or duct cells is apparent morphologically ( Slack 1995 ). The differentiation of these cells is regulated by the correct temporal and spatial expression of a series of transcription factors that direct