from terminals localized at the median eminence (ME) in yuxtaposition with tanycytes that contain deiodinase 2 (D2) and pyroglutamyl peptidase II (PPII). In response to nutrient status, arcuate neurons synthesizing POMC/CART or NPY/AgRP project to the
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Patricia Joseph-Bravo, Lorraine Jaimes-Hoy, Rosa-María Uribe, and Jean-Louis Charli
Alessandro Marsili, Edith Sanchez, Praful Singru, John W Harney, Ann Marie Zavacki, Ronald M Lechan, and P R Larsen
-producing neurons through extensive cell to cell interactions ( Riskind et al . 1987 , Tu et al . 1997 , Fekete & Lechan 2007 ). Recent evidence has suggested that inactivation of TRH in the median eminence by pyroglutamyl peptidase II (PPII), a membrane
Patricia Joseph-Bravo, Lorraine Jaimes-Hoy, Rosa-María Uribe, and Jean-Louis Charli
released from terminals localized at the median eminence (ME) in yuxtaposition with tanycytes that contain deiodinase 2 (D2) and pyroglutamyl peptidase II (PPII). In response to nutrient status, arcuate neurons synthesizing POMC/CART or NPY/AgRP project to
Patricia Joseph-Bravo, Lorraine Jaimes-Hoy, and Jean-Louis Charli
-degrading ectoenzyme (pyroglutamyl peptidase II (PPII)) present on tanycytes, a group of ependymal cells lining the third ventricle whose end-feet are in proximity with TRH terminals and portal vessels ( Sánchez et al . 2009 ). In the pituitary and upon binding to its
Nadia Schoenmakers, Kyriaki S Alatzoglou, V Krishna Chatterjee, and Mehul T Dattani
-protein coupled receptor, TRHR, and activates a Gq/11 dependent pathway involving mobilization of intracellular calcium and activation of protein kinase C, culminating in TSH synthesis and secretion. Pyroglutamyl peptidase II (PPII) activity subsequently mediates
