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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Bayer HealthCare, Biotechnology, 800 Dwight Way, Berkeley, California 94701, USA
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Introduction Glucagon-like peptide-1 (GLP-1) is a potent endogenous modulator of insulin secretion that is released by the L-cells in the crypts of the jejunum and ileum in response to a meal ( Kieffer & Habener 1999 ). Its function
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), oxyntomodulin (OXM) and glucagon-like peptide 1 (GLP-1), have been identified as players in the regulation of feeding by relaying meal-related information on nutritional status to the brain. Based on more than three decades of experimental evidence from rodent
Center for Ingestive Behavior Research, University at Buffalo, Buffalo, New York, USA
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Center for Ingestive Behavior Research, University at Buffalo, Buffalo, New York, USA
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options that cause fewer side effects, to decrease the act of binge eating. The glucagon-like peptide 1 (GLP-1) system has become an area of intense research focus due to its ability to reduce food intake and body weight in humans and non-human animals
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needed, to reach an HbA 1C level of 7% or less. Among the most prescribed drugs, the glucagon-like peptide-1 receptor agonists (GLP-1RAs) have recently attracted attention as Glp-1r -knockout animals, and GLP-1-supplemented animals exhibited
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Introduction Glucagon-like peptide 1 (GLP1), produced by intestinal enteroendocrine L-cells in response to the ingestion of nutrients ( Schirra et al . 1996 ), is highly insulinotropic and an inhibitor of gastrointestinal motility, effects that
et d'Analyses Microscopiques (SCIAM), School of Biomedical Sciences
Groupe d'Etudes sur le Remodelage Osseux et les bioMatériaux (GEROM) – LHEA, Service Commun d'Imageries
et d'Analyses Microscopiques (SCIAM), School of Biomedical Sciences
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et d'Analyses Microscopiques (SCIAM), School of Biomedical Sciences
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et d'Analyses Microscopiques (SCIAM), School of Biomedical Sciences
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et d'Analyses Microscopiques (SCIAM), School of Biomedical Sciences
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et d'Analyses Microscopiques (SCIAM), School of Biomedical Sciences
Groupe d'Etudes sur le Remodelage Osseux et les bioMatériaux (GEROM) – LHEA, Service Commun d'Imageries
et d'Analyses Microscopiques (SCIAM), School of Biomedical Sciences
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al . 2010 ). Glucagon-like peptide-1 (GLP1) is a gut hormone synthesized and secreted into the blood stream by intestinal endocrine L cells in response to a variety of stimuli ( Wu et al . 2010 ). Biologically active GLP1 is secreted as a 7–37 or 7
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play is an important role in the regulation of endocrine pancreatic secretion. The intestinal products of the proglucagon gene, glucagon-like peptide-1 (GLP-1), has been shown to contribute significantly to the overall insulin response to oral glucose
Tsukuba Research Institute, Division of Integrative Physiology, Banyu Pharmaceutical Co., Ltd, 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan
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Introduction Glucagon-like peptide-1 (GLP-1) is a hormone secreted from enteroendocrine L-cells, and is well recognized as an incretin that induces insulin secretion in a glucose-dependent manner ( Drucker 2006 ). The functions of GLP-1 have been
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on GnRH secretion. Amongst other hormones, that regulate GnRH secretion, glucagon-like peptide-1 (GLP-1) from the gut and/or the brain has been shown to stimulate GnRH secretion, although the pathway for such an effect has not been elucidated. This
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, it is noteworthy that local high concentration of ginsenosides in intestine may interact with intestinal epithelium, where numerous endocrine cells are located. Glucagon-like peptide-1 (GLP1), secreted by enteroendocrine L-cells, is one of the most