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. 2017 ). Obesity impacts on health of women across their reproductive lifespan with adverse effects on not only fertility and short-term complications of pregnancy, but also on longer-term health outcomes for both women and their children. Here, we

Introduction Maternal physiological adaptations are central to pregnancy success, balancing fetal and placental demands with the maintenance of maternal homeostasis. Among these maternal adaptations, enhanced activity of the hypothalamic

Introduction Pregnancy is a time of dramatic vascular adaptation. Through initial angiogenesis and then sustained vasodilation, the pregnant uterus achieves the biggest drop in vascular resistance of any organ system. This in turn promotes a

Introduction The GH–IGF axis is essential for growth and development before and after birth and has important anabolic and metabolic functions in adults. Its role during pregnancy has been less understood and is the primary focus of this

mouse ( Wharfe et al. 2016 ), and Wharfe and coworkers have also previously demonstrated that clock gene rhythms in the rat liver are altered by pregnancy ( Wharfe et al. 2011 ). Additionally, despite the high estradiol levels during pregnancy, the

Introduction Preeclampsia (PE) is a hypertensive disorder of pregnancy that occurs in 5–8% of all pregnancies. Significant morbidities can occur to the mother and fetus, and in extreme cases, death can result. Mothers who develop PE and babies

addition to facilitating a good maternal blood supply for nutrition–waste exchange and orchestrating endocrine mediators of pregnancy to maintain maternal physiological changes for an optimal environment for fetal development, the placenta also acts to

Introduction Successful pregnancy requires substantial maternal physiological adaptations, including increases in food intake, to maintain maternal health and allow optimal growth of the feto-placental unit to term. Growth hormone (GH) is a

). LEPRE might buffer leptin signaling by reducing its renal clearance under normal physiological conditions and prevent excessive binding of elevated circulating leptin to LEPRB in extreme metabolic conditions, such as late pregnancy ( Tu et al . 2008

. There is some evidence that placentally derived CRH and urocortins are involved in various biological functions associated with pregnancy ( Thomson 2013 , You et al . 2014 ). Thus, pregnancy represents one possible physiological state in which the