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David R Grattan

Introduction When Geoffrey Harris wrote his influential monograph on ‘Neural Control of the Pituitary Gland’, it was already apparent that prolactin, or ‘lactogenic hormone’ as he referred to it, might be controlled differently to the other

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Alejandra Abeledo-Machado, Pablo Anibal Pérez, María Andrea Camilletti, Erika Yanil Faraoni, Florencia Picech, Juan Pablo Petiti, Silvina Gutiérrez, and Graciela Diaz-Torga

Introduction Serum prolactin levels are low during the first 2 weeks of life, in both female and male rats, and then gradually increases until puberty. The progressive maturation of the neuroendocrine network involving both prolactin

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Yan Cao, Zijie Feng, Xin He, Xuyao Zhang, Bowen Xing, Yuan Wu, Taylor Hojnacki, Bryson W Katona, Jian Ma, Xiaorong Zhan, and Xianxin Hua

is continually challenged by weight gain and increasing insulin resistance ( Xue et al. 2010 ). Hormones play a crucial role in this process, especially prolactin. Increased β-cell proliferation coincides with the increase in prolactin (PRL) and

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Jason P Breves, Mayu Inokuchi, Yoko Yamaguchi, Andre P Seale, Bethany L Hunt, Soichi Watanabe, Darren T Lerner, Toyoji Kaneko, and E Gordon Grau

( Kaneko et al. 2008 , Konno et al. 2010 ). Decades of comparative study have revealed that a conserved function for prolactin (Prl) across vertebrates is the regulation of ion and water transport ( Bole-Feysot et al. 1998 ). In teleosts, Prl

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Jinglin Zhang, Jie Gao, Di Zhang, Hui Liu, Kemian Gou, and Sheng Cui

Introduction Prolactin (PRL) is a peptide hormone that is mainly synthesized and secreted from the anterior pituitary lactotrophs ( Freeman et al. 2000 , Cabrera-Reyes et al. 2017 ). With except the classical functions of PRL promoting

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Chengyuan Lin, Xue Jiang, Mulan He, Ling Zhao, Tao Huang, Zhaoxiang Bian, and Anderson O L Wong

receptors can bind PACAP and VIP with similar affinity ( Vaudry et al . 2009 ). In mammals, VIP is well-documented as a stimulator for prolactin (PRL) release ( Christian et al . 2007 ) but the functional role of PACAP in PRL regulation is controversial

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G Boaventura, G Casimiro-Lopes, C C Pazos-Moura, E Oliveira, P C Lisboa, and E G Moura

maternal prolactin (PRL) with the dopamine agonist bromo-α-ergocryptine (Bro). This method programs for obesity, hyperleptinemia, leptin resistance ( Bonomo et al . 2007 ), and hypothyroidism ( Bonomo et al . 2008 ), and symptoms (including insulin

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Laura D Ratner, Guillermina Stevens, Maria Marta Bonaventura, Victoria A Lux-Lantos, Matti Poutanen, Ricardo S Calandra, Ilpo T Huhtaniemi, and Susana B Rulli

linked to insulin resistance, since insulin promotes fat cell differentiation, enhances adipocyte glucose uptake, and inhibits adipocyte lipolysis. Although the role of prolactin in reproduction is well known, the participation of this hormone in weight

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E Y Faraoni, A I Abeledo Machado, P A Pérez, C A Marcial López, M A Camilletti, M Peña-Zanoni, S B Rulli, S Gutiérrez, and G Díaz-Torga

treatment of prolactinomas are to normalize prolactin levels in order to restore fertility and sexual function, to reduce the tumour mass to potentially relieve the visual defects and headaches and to preserve the residual pituitary function ( Liu

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Dan Li, Yan Ji, Chunlan Zhao, Yapeng Yao, Anlan Yang, Honghong Jin, Yang Chen, Mingjun San, Jing Zhang, Mingjiao Zhang, Luqing Zhang, Xuechao Feng, and Yaowu Zheng

and involution ( Macias & Hinck 2012 ). Mammary gland development requires hormones including prolactin (PRL), progesterone (P4) and estrogen (E2). PRL controls alveologenesis and lactogenesis of mammary gland through phosphorylation of JAK2/STAT5 axis