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Sophie M T Wehrens Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK

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Shelagh M Hampton Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK

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Rebecca E Finn Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK

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Debra J Skene Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK

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. 2000 , Scheer et al . 2009 ) have shown altered hormone and metabolic responses when subjects were phase shifted (i.e. intake of food at a different circadian clock time). In addition to circadian misalignment, sleep deprivation commonly occurs during

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Christina Antza Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Georgios Kostopoulos Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece

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Samiul Mostafa Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Krishnarajah Nirantharakumar Institute of Applied Health Research, University of Birmingham, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Abd Tahrani Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Disease Control in the United S to labelling sleep insufficiency as a public health epidemic ( https://www.aaas.org/news/sleep-deprivation-described-serious-public-health-problem. Accessed (September) (2021)). This is further emphasised by the

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Daniela Leite de Oliveira Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil

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Camila Hirotsu Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil

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Sergio Tufik Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil

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Monica Levy Andersen Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil

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following morning ( Roehrs et al . 2006 ). This study also found that REM sleep deprivation decreased the finger withdrawal latency for pain sensation compared to individuals that had 8 h of normal sleep. A meta-analysis corroborates these findings

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Kanta Kon Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Hiroshi Tsuneki Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Hisakatsu Ito Department of Anesthesiology, University of Toyama, Sugitani, Toyama, Japan

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Yoshinori Takemura Department of Anesthesiology, University of Toyama, Sugitani, Toyama, Japan

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Kiyofumi Sato Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Mitsuaki Yamazaki Department of Anesthesiology, University of Toyama, Sugitani, Toyama, Japan

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Yoko Ishii Department of Pathology, University of Toyama, Sugitani, Toyama, Japan

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Masakiyo Sasahara Department of Pathology, University of Toyama, Sugitani, Toyama, Japan

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Assaf Rudich Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Takahiro Maeda Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Tsutomu Wada Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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Toshiyasu Sasaoka Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan

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of partial sleep deprivation is enough to cause insulin resistance in healthy humans ( Donga et al. 2010 ). Unbalanced regulations of the hormonal and autonomic nervous systems contribute to the disrupted sleep-induced impairment of glucose

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Galit Levi Dunietz Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Lucas J Tittle Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA

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Sunni L Mumford Department of Biostatistics, Epidemiology and Informatics and Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Louise M O’Brien Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA

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Ana Baylin Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA

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Enrique F Schisterman Department of Biostatistics, Epidemiology and Informatics and Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Ronald D Chervin Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Larry J Young Center for Translational Social Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA

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– 737 . ( https://doi.org/10.1097/PSY.0000000000001091 ) Eichhorn N Treede RD & Schuh-Hofer S 2018 The role of sex in sleep deprivation related changes of nociception and conditioned pain modulation . Neuroscience 387 191 – 200 . ( https

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Shannon M Bailey Division of Molecular and Cellular Pathology, Division of Cardiovascular Diseases, Department of Pathology

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Uduak S Udoh Division of Molecular and Cellular Pathology, Division of Cardiovascular Diseases, Department of Pathology

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Martin E Young Division of Molecular and Cellular Pathology, Division of Cardiovascular Diseases, Department of Pathology

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-caloric food intake and sleep deprivation). Taken together, these studies provide strong evidence that rhythms in circulating lipid species (and presumably lipid metabolism) are not simply secondary to behavioral cycles. Circadian regulation of triglyceride

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Michael Hastings Division of Neurobiology, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

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John S O’Neill Division of Neurobiology, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

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Elizabeth S Maywood Division of Neurobiology, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

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rhythms exhibit intermediate effects, e.g. core body temperature cycles have greater amplitude when subjects sleep but are nevertheless clearly expressed during sleep deprivation. Circadian clock genes How might a single neuron be a

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Wanpitak Pongkan Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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Hiranya Pintana Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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Sivaporn Sivasinprasasn Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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Thidarat Jaiwongkam Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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Siriporn C Chattipakorn Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Department of Oral Biology and Diagnostic Science, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand

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Nipon Chattipakorn Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand

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Introduction Testosterone deprivation is a condition in which the oncentration of testosterone is lower than the normal physiological level ( Handelsman & Zajac 2004 ). This state can be found in aging male individuals. The prevalence of

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Jonathan D Johnston Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK

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Debra J Skene Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK

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rhythms and the effect of sleep and sleep deprivation on the human metabolome ( Ang et al . 2012 , Davies et al . 2014 ). This will help to better understand melatonin, circadian timing, sleep−wake regulation and associated physiological pathways

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Da-Long Ren Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Ai-Ai Sun Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Ya-Juan Li Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Min Chen Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Shu-Chao Ge Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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Bing Hu Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China

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receptor signaling: finding the path through the dark . Science's STKE : Signal Transduction knowledge Environment 2001 pe39 . Matsumoto Y Mishima K Satoh K Tozawa T Mishima Y Shimizu T Hishikawa Y 2001 Total sleep deprivation induces

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