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Prashant Regmi, Rajesh Chaudhary, Amanda J Page, Amy T Hutchison, Andrew D Vincent, Bo Liu, and Leonie Heilbronn

Introduction Time-restricted feeding (TRF) is a dietary tool that limits the duration of food intake for 6–12 h during the active phase of the day, without altering either the amount or quality of food provided ( Regmi & Heilbronn 2020 ). In

Open access

Hiroharu Mifune, Yuji Tajiri, Yusuke Sakai, Yukie Kawahara, Kento Hara, Takahiro Sato, Yoshihiro Nishi, Akinori Nishi, Ryouichi Mitsuzono, Tatsuyuki Kakuma, and Masayasu Kojima

-dark cycle (light on 07:00–19:00 h) with ad libitum or time-restricted feeding access to standard powder chow (10 kcal% fat, produced by Research Diets, Inc.: open source diet code D12450B) and water. All the experiments were performed in accordance with

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Anneleen Segers, Louis Desmet, Shu Sun, Kristin Verbeke, Jan Tack, and Inge Depoortere

pattern induced by deletion of Bmal1 are the trigger for the loss in rhythmicity and can be restored by 2 weeks of night-time restricted feeding. Materials and methods Mice studies Mice C57BL/6J mice were purchased from Janvier Labs (Le

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Majdi Masarwi, Raanan Shamir, Moshe Phillip, and Galia Gat-Yablonski

al . 2008 ) or 36 days ( Masarwi et al . 2016 ), depending on the specific experiment. The restricted group was further divided into two subgroups: continued restriction (RES group) or unrestricted re-feeding for various periods (CU group). Animals

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C García-Luna, P Soberanes-Chávez, and P de Gortari

individuals’ energy homeostasis. In fact, reports of time-restricted feeding paradigms (tRF) show the effects of feeding time on metabolism of rodents: energy homeostasis is impaired in animals eating regular chow during their resting phase (light phase), in

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JE Eckert, KL Gatford, BG Luxford, RG Campbell, and PC Owens

Birth weight is a determinant of blood leptin concentrations in adults. Since nutrition during pregnancy can affect birth weight, the hypothesis that feed intake during pregnancy alters leptin expression in progeny was examined. Leptin mRNA was measured in subcutaneous adipose tissue and leptin protein was measuredin blood plasma from 59 day old female pigs whose mothers were fed at the same restricted rate except that half were permitted to consume 35% more feed during the second quarter of pregnancy. Leptin mRNA abundance in adipose tissue (P=0.015) and plasma leptin concentration (P=0.01) were higher in progeny from mothers provided with more feed. Body weight at birth was negatively correlated with the abundance of leptin mRNA in subcutaneous fat at 59 days of age (P=0.01). This study shows for the first time that maternal nutrition during pregnancy programs postnatal leptin expression in offspring.

Restricted access

KL Gatford, KJ Quinn, PE Walton, PA Grant, BJ Hosking, AR Egan, and PC Owens

The ontogeny of the IGF endocrine system was investigated in 15 young lambs before and after weaning at 62 days of age. Before weaning, plasma IGF-I concentrations were higher in rams than ewes, and plasma concentrations of IGF-II and IGF-binding protein-3 (IGFBP-3) also tended to be higher in rams than in ewes. Feed intake of ewes and rams was restricted after weaning to remove sex differences in feed intake. Plasma concentrations of IGF-I and IGFBP-3 did not differ between rams and ewes at 100 days of age, but plasma IGF-II was higher in rams than in ewes at this time. Since circulating concentrations of GH were higher in rams than in ewes at 100 days of age, this implies that the restricted feed intake blocked the IGF-I and IGFBP-3 responses to GH. We conclude that sex differences in circulating IGF-I and IGFBP-3 concentrations in the growing lamb alter with age, and are not present when nutrition is restricted.

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K Katoh, G Furukawa, K Kitade, N Katsumata, Y Kobayashi, and Y Obara

-induced reductions in plasma GH levels become more apparent in adult animals under restricted feeding or at low feeding frequency during the day, because these conditions are known to raise basal GH levels and pulse amplitude ( Thomas et al. 1990 , 1991 ), and to

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K Katoh, K Yoshioka, H Hayashi, T Mashiko, M Yoshida, Y Kobayashi, and Y Obara

-induced reduction in plasma GH levels is more apparent in adult animals under restricted feeding or at low feeding frequency during the day because these conditions are known to raise basal GH levels and pulse amplitude ( Thomas et al. 1990 , 1991 ) and to reduce

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Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, and Mary E Wlodek

F2 male and female offspring ( Table 2 ). F2 body weight was similar between control and restricted at all time points, except at 2 months of age where F2 restricted males, but not females, were lighter (−11%) than control counterparts ( P <0