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Noriko Tagawa, Sayaka Kubota, Ikuo Kato and Yoshiharu Kobayashi

tissue function, development, and distribution. Intracellular glucocorticoid levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and 11β-HSD2. 11β-HSD1, which is abundantly expressed in the adipose tissue and in the liver, acts as

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I J Bujalska, L L Gathercole, J W Tomlinson, C Darimont, J Ermolieff, A N Fanjul, P A Rejto and P M Stewart

, specifically in omental depots, can be generated from inactive circulating cortisone (in humans) or 11-dehydrocorticosterone (in rodents) through the oxo-reductase activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; Bujalska et al . 1997 b

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Noriko Tagawa, Ryosuke Yuda, Sayaka Kubota, Midori Wakabayashi, Yuko Yamaguchi, Daisuke Kiyonaga, Natsuko Mori, Erika Minamitani, Hiroaki Masuzaki and Yoshiharu Kobayashi

activation is 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which generates active glucocorticoids (cortisol in humans and corticosterone in rodents) from inactive metabolites (cortisone in humans and 11-dehydrocorticosterone in rodents; Stewart

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M Lauterburg, G Escher, B Dick, D Ackermann and F J Frey

Y Liang G Li X 2010 11β-Hydroxysteroid dehydrogenase type 1 inhibitors as promising therapeutic drugs for diabetes: status and development . Current Medicinal Chemistry 17 412 – 422 . doi:10.2174/092986710790226147 . Hostetter TH

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Zhen Yang, Chunming Guo, Ping Zhu, Wenjiao Li, Leslie Myatt and Kang Sun

, Ebert A, Zimmermann B, Kotelevtsev YV, Mullins JJ & Seckl JR 2002 Foetal lung maturation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice. Hormone Metabolic Research 34 545 –549. Karalis K , Goodwin G & Majzoub

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Noriko Tagawa, Sayaka Kubota, Ikuo Kato and Yoshiharu Kobayashi

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Eun Hee Koh, Ah-Ram Kim, Hyunshik Kim, Jin Hee Kim, Hye-Sun Park, Myoung Seok Ko, Mi-Ok Kim, Hyuk-Joong Kim, Bum Joong Kim, Hyun Ju Yoo, Su Jung Kim, Jin Sun Oh, Chang-Yun Woo, Jung Eun Jang, Jaechan Leem, Myung Hwan Cho and Ki-Up Lee

Eeckhoute J Lefebvre P Seckl JR 2012 Peroxisome proliferator-activated receptor-γ activation induces 11β-hydroxysteroid dehydrogenase type 1 activity in human alternative macrophages . Arteriosclerosis, Thrombosis, and Vascular Biology 32

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Dawn E W Livingstone, Sarah L Grassick, Gillian L Currie, Brian R Walker and Ruth Andrew

Introduction Tissue-specific dysregulation of the glucocorticoid-generating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in rodent ( Livingstone et al . 2000 , Liu et al . 2003 ) and human obesity ( Bujalska et al . 1997 , Fraser

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Ana Tiganescu, Melanie Hupe, Yoshikazu Uchida, Theodora Mauro, Peter M Elias and Walter M Holleran

fully understood. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a bidirectional enzyme that, in intact cells, generates corticosterone from 11-dehydrocorticosterone (11-DHC) in rodents (and cortisol from cortisone in humans), regulating local GC

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Zoi Michailidou, Anthony P Coll, Christopher J Kenyon, Nicholas M Morton, Stephen O’Rahilly, Jonathan R Seckl and Karen E Chapman

normal in human idiopathic obesity ( Flier 2004 ), it has been proposed that intra-adipose glucocorticoid action is selectively increased, through increased adipose expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), the intracellular enzyme