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Julia N C Toews Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Geoffrey L Hammond Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Victor Viau Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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HPA axis ( McNeilly et al. 2010 ). Two major hepatic glucocorticoid-metabolizing enzymes contribute to HPA tone in this way: 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) and hepatic 5α-reductase type 1 (SRD5A1). Metabolic transformations

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0286
Volume/Issue:
Volume 248: Issue 1
Free access
Dawn E W Livingstone Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Emma M Di Rollo Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Chenjing Yang Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Lucy E Codrington Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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John A Mathews Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Madina Kara Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Katherine A Hughes Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Christopher J Kenyon Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Brian R Walker Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Ruth Andrew Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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, which is plausible as 5α-reductase type 1 is the only isozyme expressed in mouse liver ( Mahendroo et al . 1996 , 1997 ) whereas human liver contains both 5α-reductase type 1 and type 2 ( Evans & Goa 2003 ). These data indicate that there may be a risk

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0563
Volume/Issue:
Volume 222: Issue 2
Open access
Natali Anne Henderson Departments of Pharmacology and Therapeutics,
Obstetrics and Gynecology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada H3G 1Y6
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Ottawa, Ontario, Canada
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Sir Frederick G Banting Research Centre, 2202D1 Tunney’s Pasture, Ottawa, Ontario, Canada K1A 0L2

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Gerard M Cooke Departments of Pharmacology and Therapeutics,
Obstetrics and Gynecology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada H3G 1Y6
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Ottawa, Ontario, Canada
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Sir Frederick G Banting Research Centre, 2202D1 Tunney’s Pasture, Ottawa, Ontario, Canada K1A 0L2

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Bernard Robaire Departments of Pharmacology and Therapeutics,
Obstetrics and Gynecology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada H3G 1Y6
Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Ottawa, Ontario, Canada
Reproductive Biology Unit, Departments of Cellular and Molecular Medicine and Obstetrics and Gynecology, University of Ottawa, Sir Frederick G Banting Research Centre, 2202D1 Tunney’s Pasture, Ottawa, Ontario, Canada K1A 0L2

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of 5α-reductase (type-1 and type-2) are present in the epididymis and are differentially expressed along the tubule ( Viger & Robaire 1996 ). Previously, using gene expression profiling, we have shown that the treatment of adult male rats with

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06862
Volume/Issue:
Volume 190: Issue 3
Free access
Dawn E W Livingstone University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK

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Emma M Di Rollo University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Tracy C-S Mak University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Karen Sooy University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Brian R Walker University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Ruth Andrew University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Morgan SA Laverty GG 2013 Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice . Endocrinology 54 4536 – 4547 . ( doi:10.1210/en.2013-1592 ) Fagman JB

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0125
Volume/Issue:
Volume 232: Issue 1
Open access
C J Corbin Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA

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E L Legacki Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA

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B A Ball Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA

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K E Scoggin Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA

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S D Stanley Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA

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A J Conley Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA

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Introduction The specific short-chain dehydrogenase reductase enzymes known as 5α-reductases (types 1 and 2) are best known for their role in masculinization of the male reproductive tract ( Wilson et al . 1995 ) but are also recognized to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0175
Volume/Issue:
Volume 231: Issue 1
Free access
Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Shelley E Harris Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Toryn M Poolman Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Jonathan M Hazlehurst Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Denise V Kratschmar Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Marijana Todorčević Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Ahmad Moolla Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Niall Dempster Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Ryan C Pink Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Michael F Saikali Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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Liz Bentley Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK

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Trevor M Penning Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Claes Ohlsson Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Carolyn L Cummins Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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Matti Poutanen Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland

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Alex Odermatt Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Roger D Cox Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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described are 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and the 5α-reductases type 1 and 2 (5αR1 and 2). 11β-HSD1 converts the inactive glucocorticoid cortisone to its active form cortisol, and 11β-Hsd1 –/– mice have a beneficial metabolic phenotype

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0280
Volume/Issue:
Volume 253: Issue 3
Open access
Mark Nixon Endocrinology, Queen's Medical Research Institute, University/British Heart Foundation Centre for Cardiovascular Science, Edinburgh EH16 4TJ, UK

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Rita Upreti Endocrinology, Queen's Medical Research Institute, University/British Heart Foundation Centre for Cardiovascular Science, Edinburgh EH16 4TJ, UK

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Ruth Andrew Endocrinology, Queen's Medical Research Institute, University/British Heart Foundation Centre for Cardiovascular Science, Edinburgh EH16 4TJ, UK

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, 12, 40, 82  Breast H✓ H✓ H✓ H✓ H✓; R✓; M✓ 50, 34, 1, 85, 75 5αR1, 5α reductase type 1; 5αR2, 5α reductase type 2; H, human; R, rat; M, mouse; ✓, present; ×, absent; ±, very low levels; IC, either immunocytochemistry or immunohistochemistry; G, gamma

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0318
Volume/Issue:
Volume 212: Issue 2
Free access
Takayoshi Inoue Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan
Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Yasuhiro Miki Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Shingo Kakuo Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Akira Hachiya Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Takashi Kitahara Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Setsuya Aiba Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Christos C Zouboulis Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Hironobu Sasano Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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gift from Dr Ian Mason at the University of Edinburgh, Edinburgh), 5α-reductase type 1 (5α-red1) (a gift from Dr D W Russell at the University of Texas Southwestern Medical Center, Dallas), and epithelial membrane antigen (EMA) (Dako). Each primary

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0323
Volume/Issue:
Volume 222: Issue 3
Free access
Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Nathan Appanna Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anna Sharp Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Beverly A Hughes Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK

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Dena Digweed Diurnal Ltd, Cardiff, UK

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Martin J Whitaker Diurnal Ltd, Cardiff, UK

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Richard Ross Department of Oncology and Metabolism, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK

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Wiebke Arlt Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK

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Trevor M Penning Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Karen Morris Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Sherly George Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Brian G Keevil Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Leanne Hodson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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the 5α-reductases (type 1 and 2) are well established ( Morgan et al. 2014 , Nasiri et al. 2015 ). We have recently shown that 5β-reductase (AKR1D1) is also a potent regulator of GC availability and GR activation in human hepatocytes ( Nikolaou

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0473
Volume/Issue:
Volume 245: Issue 2
Open access
Meredith A Kelleher
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Hannah K Palliser
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David W Walker Mothers and Babies Research Centre, Department of Physiology, John Hunter Hospital and School of Biomedical Sciences, University of Newcastle, Newcastle, New South Wales 2310, Australia

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Jonathan J Hirst
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within the central nervous system (CNS). Allopregnanolone is converted from progesterone by the enzymes 5α-reductase types 1 and 2 (5αR1; 5αR2) and 3α-hydroxysteroid oxidoreductase (3α-HSOR; Compagnone & Mellon 2000 ). These enzymes are present in the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0248
Volume/Issue:
Volume 208: Issue 3
Free access