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Federico Gatto Department of Internal Medicine, Rotterdam, The Netherlands
Endocrinology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

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Richard A Feelders Department of Internal Medicine, Rotterdam, The Netherlands
Pituitary Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands

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Rob van der Pas Department of Internal Medicine, Rotterdam, The Netherlands

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Peter van Koetsveld Department of Internal Medicine, Rotterdam, The Netherlands

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Eleonora Bruzzone Department of Internal Medicine and & Medical Specialties (DIMI) and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy

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Marica Arvigo Department of Internal Medicine and & Medical Specialties (DIMI) and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy

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Fadime Dogan Department of Internal Medicine, Rotterdam, The Netherlands

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Steven Lamberts Department of Internal Medicine, Rotterdam, The Netherlands

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Diego Ferone Endocrinology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Department of Internal Medicine and & Medical Specialties (DIMI) and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy

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Leo Hofland Department of Internal Medicine, Rotterdam, The Netherlands
Pituitary Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands

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Introduction The presence of an ACTH-secreting pituitary adenoma (corticotroph adenoma) in the anterior or intermediate lobe of the pituitary gland is the cause of Cushing’s disease (CD), a severe systemic condition characterized by a chronic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0311
Volume/Issue:
Volume 245: Issue 1
Restricted access
Nicole Draper Endocrinology, Division of Medical Sciences, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Paul M Stewart Endocrinology, Division of Medical Sciences, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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, Cushing’s syndrome, demonstrate many features of the so-called metabolic syndrome. Based on the precedent of AME and ‘Cushing’s disease of the kidney’, several groups have now evaluated cortisol metabolism in patients with obesity-metabolic syndrome with

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.06019
Volume/Issue:
Volume 186: Issue 2
Free access
Federica Innocenti DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy

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Lidia Cerquetti Endocrinology, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy

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Serena Pezzilli Endocrinology, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy

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Barbara Bucci S. Pietro Hospital Fatebenefratelli, Rome, Italy

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Vincenzo Toscano Endocrinology, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy

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Rita Canipari DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy

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Antonio Stigliano Endocrinology, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy

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, a very recent study showed an increase in AMH levels during treatment with MTT, although the data were from only three patients aged 33–45 affected by Cushing’s disease ( Salenave et al. 2015 ). The administration of MTT in vitro , in COV-434, a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0203
Volume/Issue:
Volume 234: Issue 1
Free access
Jorge G Ferreira Laboratory of Molecular Cell Biology,
Institute of Histology and Embryology, Faculty of Medicine of Porto, Porto, Portugal
Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal
IPATIMUP Porto Portugal

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Célia D Cruz Laboratory of Molecular Cell Biology,
Institute of Histology and Embryology, Faculty of Medicine of Porto, Porto, Portugal
Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal
IPATIMUP Porto Portugal

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Delminda Neves Laboratory of Molecular Cell Biology,
Institute of Histology and Embryology, Faculty of Medicine of Porto, Porto, Portugal
Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal
IPATIMUP Porto Portugal

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Duarte Pignatelli Laboratory of Molecular Cell Biology,
Institute of Histology and Embryology, Faculty of Medicine of Porto, Porto, Portugal
Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal
IPATIMUP Porto Portugal

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(Lotfi & Armelin 1998, Pignatelli et al. 2002 ). Notably, adrenocortical hyperplasia can occur after prolonged ACTH exposure in patients suffering from pituitary tumours producing ACTH, a situation known as Cushing’s disease (CD; McNicol 2000 , Imaki

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06961
Volume/Issue:
Volume 192: Issue 3
Free access
Dieuwertje C E Spaanderman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Mark Nixon BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Jacobus C Buurstede Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Hetty H C M Sips Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Maaike Schilperoort Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Eline N Kuipers Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Emma A Backer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Natalie Z M Homer BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Brian R Walker BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Institute for Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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Onno C Meijer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Jan Kroon Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Glucocorticoid signaling is context dependent, and in certain scenarios, glucocorticoid receptors (GRs) are able to engage with other members of the nuclear receptor subfamily. Glucocorticoid signaling can exert sexually dimorphic effects, suggesting a possible interaction with androgen sex hormones. We therefore set out to determine the crosstalk between glucocorticoids and androgens in metabolic tissues including white adipose tissue, liver and brown adipose tissue. Thereto we exposed male C57BL/6J mice to elevated levels of corticosterone in combination with an androgen receptor (AR) agonist or an AR antagonist. Systemic and local glucocorticoid levels were determined by mass spectrometry, and tissue expression of glucocorticoid-responsive genes and protein was measured by RT-qPCR and Western blot, respectively. To evaluate crosstalk in vitro, cultured white and brown adipocytes were exposed to a combination of corticosterone and an AR agonist. We found that AR agonism potentiated transcriptional response to GR in vitro in white and brown adipocytes and in vivo in white and brown adipose tissues. Conversely, AR antagonism substantially attenuated glucocorticoid signaling in white adipose tissue and liver. In white adipose tissue, this effect could partially be attributed to decreased 11B-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid regeneration upon AR antagonism. In liver, attenuated GR activity was independent of active glucocorticoid ligand levels. We conclude that androgen signaling modulates GR transcriptional output in a tissue-specific manner.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0503
Volume/Issue:
Volume 240: Issue 1
Free access
J M Hanson Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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H S Kooistra Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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J A Mol Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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E Teske Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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B P Meij Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80.154, NL-3508 TD Utrecht, The Netherlands

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Introduction Pituitary-dependent hyperadrenocorticism (PDH) is a common spontaneous endocrine disorder in dogs, which shows many similarities with Cushing’s disease in humans ( Kemppainen & Peterson 1994 ). As in humans with Cushing’s

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06782
Volume/Issue:
Volume 190: Issue 3
Free access
Sang-Nam Lee Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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Bonnie Peng Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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Roxane Desjardins Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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John E Pintar Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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Robert Day Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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Iris Lindberg Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, 1901 Perdido Street, New Orleans, Louisiana 70112, USA
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of NJ, Piscataway, New Jersey 08854, USA
Département de Pharmacologie, Faculté de Mèdecine et Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada JIH 5N4

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null mice die at 5 weeks due to a Cushing’s disease-like disorder ( Westphal et al. 1999 ). Cushing’s disease normally arises from adrenal hypercorticos-teronism as a result of ACTH hypersecretion from anterior pituitary (reviewed by Shomali & Hussain

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0145
Volume/Issue:
Volume 192: Issue 3
Free access
Masaya Takeda Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Fumio Otsuka Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Hiroyuki Otani Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Kenichi Inagaki Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Tomoko Miyoshi Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Jiro Suzuki Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Yukari Mimura Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Toshio Ogura Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Hirofumi Makino Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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expression is restricted to adrenocorticotropin (ACTH)-secreting cells of the normal human anterior pituitary. Moreover, PPARγ is also expressed in human ACTH-secreting pituitary tumors causing Cushing’s disease and the activation of PPARγ potently inhibits

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0138
Volume/Issue:
Volume 194: Issue 1
Free access
T Taguchi Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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T Takao Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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Y Iwasaki Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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M Nishiyama Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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K Asaba Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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K Hashimoto Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan

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model of ACTH-dependent Cushing’s disease used in previous studies ( Heaney et al. 2002 ). In control (vehicle) mice transplanted with AtT20 cells, significant tumor growth with body weight loss was observed during the time of the examination (21 days

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06418
Volume/Issue:
Volume 188: Issue 2
Free access
Alejandro Ibáñez-Costa Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Esther Rivero-Cortés Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Mari C Vázquez-Borrego Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Manuel D Gahete Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Luis Jiménez-Reina Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Morphological Sciences, Universidad de Córdoba, Córdoba, Spain

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Eva Venegas-Moreno Metabolism and Nutrition Unit, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain

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Andrés de la Riva Service of Neurosurgery, Hospital Universitario Reina Sofía, Córdoba, Spain

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Miguel Ángel Arráez Neurosurgical Department, Carlos Haya Hospital, Málaga, Spain

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Inmaculada González-Molero Department of Endocrinology and Nutrition, Carlos Haya Hospital, Málaga, Spain

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Herbert A Schmid Novartis Pharma AG, Novartis Institutes for Biomedical Research, Oncology, CH-4057 Basel, Switzerland

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Silvia Maraver-Selfa Service of Endocrinology and Nutrition, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain

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Inmaculada Gavilán-Villarejo Endocrinology and Nutrition Unit, Hospital Universitario Puerta del Mar, Cádiz, Spain

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Juan Antonio García-Arnés Department of Endocrinology and Nutrition, Carlos Haya Hospital, Málaga, Spain

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Miguel A Japón Department of Pathology, Hospital Universitario Virgen del Rocío, Seville, Spain

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Alfonso Soto-Moreno Metabolism and Nutrition Unit, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain

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María A Gálvez Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Service of Endocrinology and Nutrition, Hospital Universitario Reina Sofía, Córdoba, Spain

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Raúl M Luque Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Justo P Castaño Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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, affecting octreotide response ( van der Hoek et al . 2005 , van der Pas et al . 2013 ), which suggests that octreotide therapy in untreated Cushing’s disease patients presenting with high cortisol levels would be ineffective as previously reported in two

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0332
Volume/Issue:
Volume 231: Issue 2
Free access