, for example, with re-feeding during recovery from stress, glucocorticoids may promote glycogen re-accumulation. The effects of glucocorticoids on fatty acid metabolism are less well understood than those on glucose metabolism and have not been reviewed
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David P Macfarlane, Shareen Forbes, and Brian R Walker
Nigel Turner, Gregory J Cooney, Edward W Kraegen, and Clinton R Bruce
diabetic patients . Diabetologia 51 309 – 319 . ( doi:10.1007/s00125-007-0862-2 ) Kelley DE Goodpaster B Wing RR Simoneau JA 1999 Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss . American Journal of
Sangeeta Maity, Dipak Kar, Kakali De, Vivek Chander, and Arun Bandyopadhyay
depletion ( Ingwall 2009 ). A number of important genes involved in fatty acid metabolism (e.g. medium-chain fatty acyl co-A dehydrogenase ( Mcad ( Acadm )), carnitine palmitoyl transferase-1 beta ( Cpt1β ), fatty acid transport protein ( Fatp ( Slc27a1
Fausto Bogazzi, Francesco Raggi, Federica Ultimieri, Dania Russo, Aldo D'Alessio, Antonella Manariti, Sandra Brogioni, Luca Manetti, and Enio Martino
example, triggered by hypertrophic hearts) superimpose on those regulated by GH ( Fig. 7 ). Figure 7 Proposed model of regulation of fatty acids metabolism in the heart of acromegalic mice. GH excess, through reduction in the inhibitory ERK 1/2 pathway
Oliver C Watkins, Mohammed Omedul Islam, Preben Selvam, Reshma Appukuttan Pillai, Amaury Cazenave-Gassiot, Anne K Bendt, Neerja Karnani, Keith M Godfrey, Rohan M Lewis, Markus R Wenk, and Shiao-Yng Chan
Bartha JL Perdomo G 2015 Glucose and fatty acid metabolism in placental explants from pregnancies complicated with gestational diabetes mellitus . Reproductive Sciences 798 – 801 . ( https://doi.org/10.1177/1933719114561558 ) Visiedo F
Rengasamy Palanivel, Vivian Vu, Min Park, Xiangping Fang, and Gary Sweeney
contractile performance is derived from fatty acids while the remainder (∼30%) is principally obtained via metabolism of glucose ( Stanley et al . 2005 , An & Rodrigues 2006 ). Well-controlled fatty acid metabolism is also important to prevent triglyceride
Rengasamy Palanivel, Vivian Vu, Min Park, Xiangping Fang, and Gary Sweeney
Cristina Velasco, Marta Librán-Pérez, Cristina Otero-Rodiño, Marcos A López-Patiño, Jesús M Míguez, José Miguel Cerdá-Reverter, and José L Soengas
) through several mechanisms such as i) fatty acid metabolism by means of inhibition of carnitine palmitoyltransferase 1 (CPT1) to import fatty acid-CoA into the mitochondria for oxidation; ii) binding to fatty acid translocase (FAT/CD36), and further
Giselle Adriana Abruzzese, Maria Florencia Heber, Silvana Rocío Ferreira, María José Ferrer, and Alicia Beatriz Motta
was analyzed. Fatty acid metabolism and availability from triglycerides were evaluated by measuring mRNA levels of Srebp1 and Atgl , respectively. To evaluate cholesterol bioavailability, the mRNA expression of the cholesterol receptors: Ldlr and
William WN Jr, RB Ceddia, and R Curi
Leptin directly increases the rate of exogenous glucose and fatty acids oxidation in isolated adipocytes. However, the effects of leptin on fatty acid metabolism in white adipose tIssue have not been examined in detail. Here, we report that in adipocytes incubated for 6 h in the presence of leptin (10 ng/ml), the insulin-stimulated de novo fatty acid synthesis was inhibited by 36% (P<0.05), while the exogenous oxidation of acetic and oleic acids was increased by 50% and 76% respectively. Interestingly, leptin did not alter the oxidation of intracellular fatty acids. Leptin-incubated cells presented a 16-fold increase in the incorporation of oleic acid into triglyceride (TG) and a 123% increase in the intracellular TG hydrolysis (as measured by free fatty acids release). Fatty acid-TG cycling was not affected by leptin. By employing fatty acids radiolabeled with (3)H and (14)C, we could determine the concomitant influx of fatty acids (incorporation of fatty acids into TG) and efflux of fatty acids (intracellular fatty acids oxidation and free fatty acids release) in the incubated cells. Leptin increased by 30% the net efflux of fatty acids from adipocytes. We conclude that leptin directly inhibits de novo synthesis of fatty acids and increases the release and oxidation of fatty acids in isolated rat adipocytes. These direct energy-dissipating effects of leptin may play an important role in reducing accumulation of fatty acids into TG of rat adipose cells.
