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Diego Safian Reproductive Biology Group, Division Developmental Biology, Department of Biology, Institute of Biodynamics and Biocomplexity, Faculty of Science, University of Utrecht, NL-3584 CH Utrecht, The Netherlands

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Najoua Ryane Reproductive Biology Group, Division Developmental Biology, Department of Biology, Institute of Biodynamics and Biocomplexity, Faculty of Science, University of Utrecht, NL-3584 CH Utrecht, The Netherlands

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Jan Bogerd Reproductive Biology Group, Division Developmental Biology, Department of Biology, Institute of Biodynamics and Biocomplexity, Faculty of Science, University of Utrecht, NL-3584 CH Utrecht, The Netherlands

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Rüdiger W Schulz Reproductive Biology Group, Division Developmental Biology, Department of Biology, Institute of Biodynamics and Biocomplexity, Faculty of Science, University of Utrecht, NL-3584 CH Utrecht, The Netherlands
Reproduction and Developmental Biology Group, Institute of Marine Research, Nordnes, Bergen, Norway

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-stimulating hormone (Fsh) are major modulators of vertebrate spermatogenesis. Upon gonadotropin signaling, somatic cells such as SCs, LCs and myoid cells produce paracrine factors modulating spermatogonial activity ( Oatley et al. 2009 , Ding et al. 2011 , Chen

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Yuxin Xie School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Lianhe Chu School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Yun Liu School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Kathy W Y Sham School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Jianzhen Li School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
College of Life Sciences, Northwest Normal University, Lanzhou, China

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Christopher H K Cheng School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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control of gonadotropic hormone stimulation of their receptors in the testes ( Pudney 1995 , Schulz et al . 2010 ). More specifically, both pituitary gonadotropins including luteinizing hormone (LH) and follicle-stimulating hormone (FSH) exert their

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Diego Crespo Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands

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Moline Severino Lemos Laboratory of Cell Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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Yu Ting Zhang State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Fujian, People’s Republic of China
Institute of Oceanography, Minjiang University, Fuzhou, People’s Republic of China

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Diego Safian Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands

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Birgitta Norberg Institute of Marine Research, Austevoll Research Station, Storebø, Norway

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Jan Bogerd Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands

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Rüdiger W Schulz Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands
Research Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway

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production ( Frungieri et al. 2015 ). In rat, FSH stimulated Sertoli cell PG production ( Jannini et al. 1994 ). In fetal mice, Sertoli cell-derived PGD 2 keeps spermatogonia in an undifferentiated state by autocrine stimulation of CYP26B1 activity that

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Se-Min Kim The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Farhath Sultana The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Steven Sims The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Judit Gimenez-Roig The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Victoria Laurencin The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anusha Pallapati The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Satish Rojekar The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tal Frolinger The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Weibin Zhou The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anisa Gumerova The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anne Macdonald The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Vitaly Ryu The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Daria Lizneva The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Funda Korkmaz The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tony Yuen The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Mone Zaidi The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Introduction Two gonadotropins secreted by the anterior pituitary gland, namely, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), along with thyroid-stimulating hormone (TSH), as well as their respective receptors, exhibit

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Yan Wang Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong Province, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China

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Mengqi Zhang Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong Province, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China

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Zhikun Huan Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong Province, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China

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Shanshan Shao Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong Province, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China

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Xiujuan Zhang Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong Province, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China

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Dehuan Kong Department of Endocrinology, Taian City Central Hospital, Taian, Shandong Province, China

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Jin Xu Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong Province, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China

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of OA have been linked to the decrease in estrogen that occurs with the onset of menopause ( Martin-Millan & Castaneda 2013 ). Although FSH levels increase in parallel, the effect of FSH on cartilage and chondrocytes has never been explored. FSH is

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Juliana I Candelaria Department of Animal Science, University of California Davis, Davis, California, USA

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Maria B Rabaglino Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark

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Anna C Denicol Department of Animal Science, University of California Davis, Davis, California, USA

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Introduction Ovarian antral follicles require gonadotropin stimulation for development and ovulation whereas preantral follicles seem capable of development in the absence of follicle-stimulating hormone (FSH) and luteinizing hormone (LH

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Sarah J Meachem Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Saleela M Ruwanpura Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Jessica Ziolkowski Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Jacquelyn M Ague Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Michael K Skinner Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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Kate L Loveland Prince Henry’s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Monash Institute for Medical Research, Monash University, Clayton, Victoria, 3168, Australia
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, USA
The Australian Research Council Centre of Excellence in Biotechnology and Development

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spermatogenic wave are under investigation and appear to be influenced by a complex network of interacting signals. It is known that pituitary-derived follicle stimulating hormone (FSH) exerts its effects on the developing germ cells indirectly, as only the

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Marie M Devillers Sorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l’Axe Gonadotrope U1133, Paris, France

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Florence Petit Sorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l’Axe Gonadotrope U1133, Paris, France

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Victoria Cluzet Sorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l’Axe Gonadotrope U1133, Paris, France

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Charlotte M François Sorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l’Axe Gonadotrope U1133, Paris, France

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Frank Giton APHP CIB GHU Sud Henri Mondor, INSERM IMRB U955, Eq.07, Faculté de Médecine, Créteil, France

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Ghislaine Garrel Sorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l’Axe Gonadotrope U1133, Paris, France

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Joëlle Cohen-Tannoudji Sorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l’Axe Gonadotrope U1133, Paris, France

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Céline J Guigon Sorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l’Axe Gonadotrope U1133, Paris, France

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Introduction In mammals, the infantile period is characterized by a transient elevation in the levels of the two gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) shortly after birth ( Döhler & Wuttke 1975

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Saleela M Ruwanpura Prince Henry's Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash Institute of Medical Research and ARC Centre of Excellence in Biotechnology and Development, Clayton, Victoria 3168, Australia
Prince Henry's Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash Institute of Medical Research and ARC Centre of Excellence in Biotechnology and Development, Clayton, Victoria 3168, Australia

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Robert I McLachlan Prince Henry's Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash Institute of Medical Research and ARC Centre of Excellence in Biotechnology and Development, Clayton, Victoria 3168, Australia
Prince Henry's Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash Institute of Medical Research and ARC Centre of Excellence in Biotechnology and Development, Clayton, Victoria 3168, Australia

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Peter G Stanton Prince Henry's Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash Institute of Medical Research and ARC Centre of Excellence in Biotechnology and Development, Clayton, Victoria 3168, Australia

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Kate L Loveland Prince Henry's Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash Institute of Medical Research and ARC Centre of Excellence in Biotechnology and Development, Clayton, Victoria 3168, Australia

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Sarah J Meachem Prince Henry's Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash Institute of Medical Research and ARC Centre of Excellence in Biotechnology and Development, Clayton, Victoria 3168, Australia

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endocrine signals including follicle-stimulating hormone (FSH) and luteinizing hormone (LH)/testosterone (T). A key role for FSH in regulating the size of the Sertoli cell population in early postnatal life has been attributed to its stimulatory effect on

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Xin Li State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China

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Hongjiao Li State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

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Di Zhang College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

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Guojin Xu State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China

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Jinglin Zhang Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

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Sheng Cui State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China
Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, People’s Republic of China

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& Elamraoui 1995 , Kelberman et al. 2009 ). Pituitary gonadotroph secretes luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and regulates mammalian reproductive process through hypothalamus-pituitary-gonadal (HPG) axis ( Christensen et al

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