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Nilli Zmora, Ten-Tsao Wong, John Stubblefield, Berta Levavi-Sivan and Yonathan Zohar

vertebrate species, for which the hypothalamic gonadotropin-releasing-hormone (GnRH) is pivotal to the regulation of reproduction. During the past decade, numerous known and novel neuropeptides have been implicated in the upstream control of GnRH neurons and

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Takayoshi Ubuka and George E Bentley

Introduction Vertebrate reproduction is primarily regulated by GnRH, of which there are at least three distinct forms, namely GnRH-I, -II, and -III. One or more of these forms has been found in all vertebrates studied to date, regulating

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Shiping Su, Xiaoxia Sun, Xiuhong Zhou, Fuigui Fang and Yunsheng Li

revealed that athymic nudes have reduced numbers of brain gonadotropin-releasing hormone (GnRH) neurons and pituitary gonadotropic cells, compared with heterozygotes, and neonatal thymulin gene therapy could prevent these changes ( Reggiani et al . 2009 b

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Andrea C Wilson, M Shahriar Salamat, Ryan J Haasl, Kelly M Roche, Anjali Karande, Sivan Vadakkadath Meethal, Ei Terasawa, Richard L Bowen and Craig S Atwood

Introduction Luteinizing hormone (LH) is secreted from gonadotropes of the anterior pituitary into the bloodstream following pulsatile stimulation by hypothalamic gonadotropin-releasing hormone I (GnRH I; Larsen et al. 2002 ). LH

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Sergio A Arispe, Betty Adams and Thomas E Adams

. Although estrogens can affect gonadotropin synthesis and secretion by influencing gonadotropin-releasing hormone (GnRH) release from hypothalamic loci, direct action of estrogens on gonadotrope cells is suggested by experiments using in vivo and in vitro

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J Shaik Mohamed and I A Khan

Introduction Gonadotropin-releasing hormone (GnRH) plays an important role in the control of vertebrate reproduction. Similarly, GnRH or GnRH-like peptides occur in some protochordate and invertebrate species ( Adams et al. 2003

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Valerie M Harris, Sachin V Bendre, Francina Gonzalez De Los Santos, Alemu Fite, Ahmad El-Yaman El-Dandachli, Lyazat Kurenbekova, Abdul B Abou-Samra and Colleen Buggs-Saxton

Introduction GnRH is the master regulator of the hypothalamic–pituitary–gonadal (H–P–G) reproductive axis. It binds to receptors in the pituitary gonadotroph cell to increase the synthesis and secretion of LH and FSH, both of which stimulate the

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Hiroyuki Otani, Fumio Otsuka, Masaya Takeda, Tomoyuki Mukai, Tomohiro Terasaka, Tomoko Miyoshi, Kenichi Inagaki, Jiro Suzuki, Toshio Ogura, Mark A Lawson and Hirofumi Makino

Introduction Reproduction in mammals is controlled by the coordination between episodic release of GNRH and GNRH-dependent secretion of pituitary gonadotropins. GNRH is a highly conserved decapeptide, which is secreted by a scattered group of cells

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Helen L Henderson, Julie Townsend and Domingo J Tortonese

addition to the established actions of PRL at the level of the hypothalamus affecting gonadotrophin-releasing hormone (GnRH) output, interactions between the gonadotrophic and PRL axes occur at the level of the pituitary gland. Indeed, close associations

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Massimo Zerani, Francesco Parillo, Gabriele Brecchia, Gabriella Guelfi, Cecilia Dall'Aglio, Lorena Lilli, Margherita Maranesi, Anna Gobbetti and Cristiano Boiti

Introduction GNRH is a hypothalamic neuronal secretory decapeptide that plays a central regulatory role in mammalian reproductive physiology. GNRH influences reproductive processes mainly by regulating pituitary gonadotropin synthesis and release