(HPT). Above the blue line are marked some of the main findings in techniques or in cellular biology. Below are those related to the HPT axis. Space constraints makes it impossible to cite each piece of work, and some examples represent the ideas and
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Patricia Joseph-Bravo, Lorraine Jaimes-Hoy, Rosa-María Uribe, and Jean-Louis Charli
Z Zhang, P H Bisschop, E Foppen, H C van Beeren, A Kalsbeek, A Boelen, and E Fliers
. n = 8−10 per group. * P < 0.05, ** P < 0.01. Effect of T 3 administration in the PVN on HPT axis Placement of T 3 Ps in the PVN did not change Trh mRNA in the PVN or VMH region, while decreasing pituitary Tshb mRNA expression
J Fahrenkrug, B Georg, J Hannibal, and H L Jørgensen
Introduction There is growing evidence that endocrine body rhythms including the hypothalamic–pituitary–thyroid (HPT) axis are regulated by the circadian timing system, which consists of the master pacemaker located in the hypothalamic
Sylvia V H Grommen, Lutgarde Arckens, Tim Theuwissen, Veerle M Darras, and Bert De Groef
( Decuypere et al . 1990 ). THs are known to play an important role in controlling their own secretion through feedback effects acting on the different levels of the hypothalamo–pituitary–thyroidal (HPT) axis. In birds, information on TH feedback is scarce
Emmely M de Vries, Eric Fliers, and Anita Boelen
alterations in the central part of the hypothalamus–pituitary–thyroid (HPT) axis are combined with reduced production of T 3 and impaired clearance of rT 3 by the liver, and with specific changes in peripheral TH metabolism in major T 3 target organs
Mohammad Reza Safarinejad, Kamran Azma, and Ali Asgar Kolahi
exercise ( Kujala et al . 1990 ). Qualitatively and quantitatively normal spermatogenesis is critically dependent on an intact hypothalamus–pituitary–testis (HPT) axis. Androgens are essential for the maintenance of normal spermatogenesis. Reactive oxygen
Edwin J W Geven, Gert Flik, and Peter H M Klaren
( Walpita et al . 2007 ). Stimulatory effects of cortisol on the HPT axis have also been suggested in teleost fish. In brook charr ( Salvelinus fontinalis ) long-term exposure to cortisol increased the hepatic conversion of T 4 to T 3 ( Vijayan et al
A Boelen, J Kwakkel, X G Vos, W M Wiersinga, and E Fliers
Introduction During fasting, profound changes occur in the hypothalamic part of the hypothalamic–pituitary–thyroid axis (HPT axis), i.e. increased type 2 deiodinase (D2) activity in the arcuate nucleus (ARC) ( Diano et al. 1998
Patricia Joseph-Bravo, Lorraine Jaimes-Hoy, and Jean-Louis Charli
the brainstem play a key role in regulation of the HPT axis in response to cold. Both noradrenergic (LC and NTS, orange arrows) and adrenergic (C1–3 regions, brown arrow) axons establish contacts with TRH neurons in the PVN ( Fekete & Lechan 2014 ). AH
C García-Luna, P Soberanes-Chávez, and P de Gortari
mRNA expression from non-hypophysiotropic aPVN neurons showed no significant differences in animals either fed in light or in darkness phase ( Fig. 2A , B , C , J ). Hypophysiotropic TRHergic neurons of medial and caudal PVN direct HPT axis function