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Ashley Patton
Ashley Patton
Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
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Tyler Church
Tyler Church
Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
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Caroline Wilson
Caroline Wilson
Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA
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Jean Thuma
Jean Thuma
Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
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Douglas J Goetz
Douglas J Goetz
Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
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Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
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Darlene E Berryman
Darlene E Berryman
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
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Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
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Edward O List
Edward O List
Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
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Frank Schwartz
Frank Schwartz
Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
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Kelly D McCall
Kelly D McCall
Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
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Introduction Obesity is the single most important risk factor for the development of nonalcoholic fatty liver disease (NAFLD), which is the most prevalent liver disease in the western hemisphere ( Lazo & Clark 2008 , Bellentani et al . 2010
Rodrigo Martins Pereira
Rodrigo Martins Pereira
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Kellen Cristina da Cruz Rodrigues
Kellen Cristina da Cruz Rodrigues
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Chadi Pellegrini Anaruma
Chadi Pellegrini Anaruma
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Marcella Ramos Sant’Ana
Marcella Ramos Sant’Ana
Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Thaís Dantis Pereira de Campos
Thaís Dantis Pereira de Campos
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Rodrigo Stellzer Gaspar
Rodrigo Stellzer Gaspar
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Raphael dos Santos Canciglieri
Raphael dos Santos Canciglieri
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Diego Gomes de Melo
Diego Gomes de Melo
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Rania A Mekary
Rania A Mekary
Department of Neurosurgery, Computational Neuroscience Outcomes Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Social and Administrative Sciences, School of Pharmacy, MCPHS University, Boston, Massachusetts, USA
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Department of Social and Administrative Sciences, School of Pharmacy, MCPHS University, Boston, Massachusetts, USA
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Adelino Sanchez Ramos da Silva
Adelino Sanchez Ramos da Silva
School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil
Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil
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Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil
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Dennys Esper Cintra
Dennys Esper Cintra
Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Eduardo Rochete Ropelle
Eduardo Rochete Ropelle
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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José Rodrigo Pauli
José Rodrigo Pauli
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Leandro Pereira de Moura
Leandro Pereira de Moura
Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil
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Introduction Nonalcoholic fatty liver disease (NAFLD) is a pre-condition for most common liver diseases, and it can be developed from hepatic steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, to hepatocellular carcinoma (HCC) ( Tilg
Lei Yu
Lei Yu
Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China
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Haoran Wang
Haoran Wang
State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing, China
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Xiaoxue Han
Xiaoxue Han
State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing, China
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Honghui Liu
Honghui Liu
State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing, China
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Dalong Zhu
Dalong Zhu
Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China
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Wenhuan Feng
Wenhuan Feng
Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China
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Jinhui Wu
Jinhui Wu
State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing, China
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Yan Bi
Yan Bi
Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China
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Introduction Non-alcoholic fatty liver disease (NAFLD), a major epidemic chronic liver disease worldwide, is often accompanied by systemic metabolic disorders, such as obesity, type 2 diabetes and cardiovascular diseases ( Byrne & Targher 2015
Guangcui Xu
Guangcui Xu
School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China
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Tingting Yan
Tingting Yan
School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China
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Qiang Peng
Qiang Peng
School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China
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Haibin Li
Haibin Li
School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China
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Weidong Wu
Weidong Wu
School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China
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Xianwen Yi
Xianwen Yi
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
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Yingzheng Zhao
Yingzheng Zhao
School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China
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Introduction In association with the obesity pandemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) and its progressive form, nonalcoholic steatohepatitis ( Sanyal et al . 2010 ), is rising in the whole world and is estimated to
Gabriel Forn-Cuní
Gabriel Forn-Cuní
Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain
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Monica Varela
Monica Varela
Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain
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Conrado M Fernández-Rodríguez
Conrado M Fernández-Rodríguez
Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain
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Antonio Figueras
Antonio Figueras
Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain
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Beatriz Novoa
Beatriz Novoa
Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain
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diseases are part of a condition termed metabolic syndrome. The hepatic component of metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This term comprises a wide range of progressive liver injuries including bland steatosis, variable degrees
Ya Liu
Ya Liu
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Xiaoqing Zhou
Xiaoqing Zhou
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Ye Xiao
Ye Xiao
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Changjun Li
Changjun Li
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Yan Huang
Yan Huang
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Qi Guo
Qi Guo
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Tian Su
Tian Su
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Lei Fu
Lei Fu
Department of Infectious Diseases, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Liping Luo
Liping Luo
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
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Introduction Nonalcoholic fatty liver disease (NAFLD), characterized mainly by hepatic steatosis, is the most common liver disease worldwide ( Birkenfeld & Shulman 2014 , Meex & Watt 2017 ). It is reported that NAFLD is closely associated
Lise Margrethe Sjøgaard-Frich
Lise Margrethe Sjøgaard-Frich
L Sjøgaard-Frich, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Morten Sølling Henriksen
Morten Sølling Henriksen
M Henriksen, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Shi Min Lam
Shi Min Lam
S Lam, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Frida Jolande Birkbak
Frida Jolande Birkbak
F Birkbak, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Dominika Czaplinska
Dominika Czaplinska
D Czaplinska, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Mette Flinck
Mette Flinck
M Flinck, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Stine F. Pedersen
Stine F. Pedersen
S Pedersen, Department of Biology, University of Copenhagen, Kobenhavn, Denmark
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Non-alcoholic fatty liver disease (NAFLD) is the fastest growing cause of liver-associated death globally. Whole-body knockout (KO) of Na+/H+ exchanger 1 (NHE1, SLC9A1) was previously proposed to protect against high fat diet-induced liver damage, however, mechanistic insight was lacking. The aim of the present work was to address this question in vitro to determine how NHE1 specifically in hepatocytes impacts lipid overload-induced inflammation, fibrosis, and hepatocyte- hepatic stellate cell (HSC) crosstalk. We induced palmitate (PA)-based steatosis in AML12 and HepG2 hepatocytes, manipulated NHE1 activity pharmacologically and by CRISPR-Cas knockout (KO) and -overexpression, and measured intracellular pH (pHi), steatosis-associated inflammatory and fibrotic mediators and cell death. PA treatment increased NHE1 mRNA levels but modestly reduced NHE1 protein expression and hepatocyte pHi. NHE1 KO in hepatocytes did not alter lipid droplet accumulation but reduced inflammatory signaling (p38 MAPK activity), lipotoxicity (4-HNE accumulation) and apoptosis (PARP cleavage). Conditioned medium from PA-treated hepatocytes increased expression of NHE1 and of the fibrosis regulator tissue inhibitor of matrix metalloproteases-2 (TIMP2) in LX-2 HSCs, in a manner abolished by NHE1 KO in hepatocytes. We conclude that NHE1 is regulated in NAFLD in vitro and contributes to the ensuing damage by aggravating hepatocyte injury and stimulating hepatocyte-HSC crosstalk.
Christopher M Mulligan
Christopher M Mulligan
Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
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Jacob E Friedman
Jacob E Friedman
Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
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properly. Depending on the health of the mother, maternal microbe communities may already be imbalanced when passed on to the infant. In children, metabolic diseases, including obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD), along
João Paulo G Camporez
João Paulo G Camporez
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Mohamed Asrih
Mohamed Asrih
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Dongyan Zhang
Dongyan Zhang
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Mario Kahn
Mario Kahn
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Varman T Samuel
Varman T Samuel
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Michael J Jurczak
Michael J Jurczak
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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François R Jornayvaz
François R Jornayvaz
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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Department of Internal Medicine, Howard Hughes Medical Institute, Service of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
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(NHANES), it is estimated that more than 34% of adults are obese and 68% are overweight or obese ( Flegal et al . 2010 ). In parallel with obesity, nonalcoholic fatty liver disease (NAFLD), which is now the most prevalent chronic liver disease in the USA
Qiong Lv
Qiong Lv
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Rufei Gao
Rufei Gao
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Laboratory of Lipids and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Laboratory of Lipids and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Chuan Peng
Chuan Peng
School of Public Health and Management, Chongqing Medical University, Chongqing, China
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Juan Yi
Juan Yi
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Lulu Liu
Lulu Liu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Shumin Yang
Shumin Yang
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Danting Li
Danting Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Jinbo Hu
Jinbo Hu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Ting Luo
Ting Luo
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Mei Mei
Mei Mei
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Ying Song
Ying Song
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Chaodong Wu
Chaodong Wu
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
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Xiaoqiu Xiao
Xiaoqiu Xiao
School of Public Health and Management, Chongqing Medical University, Chongqing, China
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Qifu Li
Qifu Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Introduction Excess hepatic deposition of lipids, especially triglyceride (TG), is one of the important features of nonalcoholic fatty liver disease (NAFLD). Over-nutrition, metabolic diseases and genetic factors were widely considered to
