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Hiroki Saito, Tomoya Nakamachi, Kazuhiko Inoue, Ryuji Ikeda, Kazuo Kitamura, Naoto Minamino, Seiji Shioda and Atsuro Miyata

Introduction Originally isolated from porcine spinal cord, neuromedin B (NMB) is a member of the bombesin-like peptide family, which also includes gastrin-releasing peptide (GRP) in mammals ( Minamino et al . 1983 , Ohki-Hamazaki 2000 ). NMB has

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EE Ladenheim, LL Hampton, AC Whitney, WO White, JF Battey and TH Moran

Bombesin (BN) interacts with two mammalian receptor subtypes termed gastrin-releasing peptide (GRP)-preferring (GRP-R) and neuromedin B (NMB)-preferring (NMB-R) that may mediate the satiety action of BN. We examined the feeding behavior of mice that were deficient in the GRP-R (GRP-R KO) to assess the overall contribution of this receptor subtype in the feeding actions of BN-related peptides. GRP-R KO mice failed to suppress glucose intake in response to systemically administered BN and GRP(18-27), whereas both peptides elicited a potent reduction of intake in wild-type (WT) mice. Neither GRP-R KO nor WT mice suppressed glucose intake following NMB administration. Unlike the impaired responses to BN-like peptides, the feeding inhibitory action of cholecystokinin was enhanced in GRP-R KO mice. Consistent with behavioral results, GRP-R KO mice also exhibited a reduction in c-Fos immunoreactivity in the nucleus of the solitary tract (NTS) and paraventricular nucleus (PVN) following peripheral administration of BN. An evaluation of meal patterns showed that GRP-R KO mice ate significantly more at each meal than WT mice, although total 24 h food consumption was equivalent. A long-term analysis of body weight revealed a significant elevation in GRP-R KO mice compared with WT littermates beginning at 45 weeks of age. These data suggest that the GRP-R mediates the feeding effects of BN-like peptides and participates in the termination of meals in mice.

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M A L Costa da Veiga, K de Jesus Oliveira, F H Curty and C C Pazos de Moura

euthyroid ones. This enhanced action of an inhibitory local factor may be contributing to the suppression of TSH release present in hyperthyroidism. Other important local TSH-releasing inhibitors, such as the bombesin-like peptide, neuromedin B has its

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K J Oliveira, G S M Paula, R H Costa-e-Sousa, L L Souza, D C Moraes, F H Curty and C C Pazos-Moura

. Gastrointestinal and Liver Physiology 279 G126 –G131. Ortiga-Carvalho TM , Polak J, McCann S & Pazos-Moura CC 1996 Effect of thyroid hormones on pituitary neuromedin B and possible interaction between thyroid hormones and

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A Boelen, J Kwakkel, X G Vos, W M Wiersinga and E Fliers

others in the thyrotropic cells play an important role in TSHβ gene expression ( Shupnik 2000 ), and it is possible that a period of fasting affects these proteins also independently of leptin. A recent study has shown that neuromedin B (NB), a bombesin

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Marco Aurélio Liberato Costa da Veiga, Flávia Fonseca Bloise, Ricardo Henrique Costa-e-Sousa, Luana Lopes Souza, Norma Aparecida dos Santos Almeida, Karen Jesus Oliveira and Carmen Cabanelas Pazos-Moura

rats . Journal of Endocrinology 191 459 – 463 . Ortiga-Carvalho TM Polak J McCann S Pazos-Moura CC 1996 Effect of thyroid hormones on pituitary neuromedin B and possible interaction between thyroid hormones and neuromedin B on

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Camila Calvino, Luana L Souza, Ricardo H Costa-e-Sousa, Norma A S Almeida, Isis H Trevenzoli and Carmen C Pazos-Moura

Reviews 8 288 – 308 . ( doi:10.1210/edrv-8-3-288 ) Ortiga-Carvalho TM Polak J McCann S Pazos-Moura CC 1996 Effect of thyroid hormones on pituitary neuromedin B and possible interaction between thyroid hormones and neuromedin B on

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Renata Lopes Araujo, Bruno Moulin de Andrade, Álvaro Souto Padron de Figueiredo, Monique Leandro da Silva, Michelle Porto Marassi, Valmara dos Santos Pereira, Eliete Bouskela and Denise P Carvalho

′-deiodinase by thyroid hormones and in fasted and diabetic rats . Endocrinology 133 1715 – 1723 . Ortiga-Carvalho TM Polak J McCann S Pazos-Moura CC 1996 Effect of thyroid hormones on pituitary neuromedin B and possible interaction between thyroid

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Aline Cordeiro, Luana Lopes de Souza, Lorraine Soares Oliveira, Larissa Costa Faustino, Letícia Aragão Santiago, Flavia Fonseca Bloise, Tania Maria Ortiga-Carvalho, Norma Aparecida dos Santos Almeida and Carmen Cabanelas Pazos-Moura

Veiga MA Aoki K Ohki-Hamazaki H Wada K Wada E Pazos-Moura CC 2006 Disruption of neuromedin B receptor gene results in dysregulation of the pituitary–thyroid axis . Journal of Molecular Endocrinology 36 73 – 80 . ( doi:10.1677/jme.1

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Isabela Teixeira Bonomo, Patrícia Cristina Lisboa, Magna Cottini Fonseca Passos, Simone Bezerra Alves, Adelina Martha Reis and Egberto Gaspar de Moura

Salardi S Loche S 2006 The natural history of euthyroid Hashimoto's thyroiditis in children . Journal of Pediatrics 149 827 – 832 . Rettori V Pazos-Moura CC Moura EG Polak J McCann SM 1992 Role of neuromedin B in the control of