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Sihan Lv Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Xinchen Qiu Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Jian Li Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Jinye Liang Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Weida Li Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Chao Zhang Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Zhen-Ning Zhang Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Bing Luan Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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levels during the fasted state ( Longuet et al . 2008 ). PPARα, a master transcription factor that regulates expression of fatty acid oxidation genes such as Aox , Cpt1a and Medium-chain acyl-CoA dehydrogenase ( Mcad ), serves as the major target of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0649
Volume/Issue:
Volume 234: Issue 2
Free access
Sung-Soo Park Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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Yeon-Joo Lee Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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Sooyeon Song Division of Animal Science, College of Agriculture & Life Science, Chonnam National University, Gwangju, South Korea

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Boyong Kim Gwangju Center, Korea Basic Science Institute, Gwangju, South Korea

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Hyuno Kang Gwangju Center, Korea Basic Science Institute, Gwangju, South Korea

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Sejong Oh Division of Animal Science, College of Agriculture & Life Science, Chonnam National University, Gwangju, South Korea

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Eungseok Kim Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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(SREBP-1c) and peroxisome proliferator-activated receptor α (PPARα), are important for the transcriptional regulation of these hepatic functions ( Kersten et al . 2000 , Horton et al . 2002 ). SREBP-1c is initially synthesized as an inactive

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0592
Volume/Issue:
Volume 237: Issue 2
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Ana B Ropero Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Pablo Juan-Picó Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Alex Rafacho Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Esther Fuentes Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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F Javier Bermúdez-Silva Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Enrique Roche Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Ivan Quesada Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Fernando Rodríguez de Fonseca Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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Angel Nadal Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain
Instituto Bioingeniería, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Laboratorio de Medicina Regenerativa and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Universidad Miguel Hernández de Elche, Elche 03202, Alicante, Spain

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superfamily of ligand activated transcription factors ( Robinson-Rechavi et al . 2003 ). PPARs, particularly PPARα and γ, are regulators of lipid metabolism because they act as lipid sensors. Therefore, PPAR ligands represent important pharmaceutical agents

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0397
Volume/Issue:
Volume 200: Issue 2
Free access
Sarah Teillon Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA

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German A Calderon Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA

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Maribel Rios Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA

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increases susceptibility to type 2 diabetes, liver cirrhosis, and cardiovascular disease. Recently, the transcription factor peroxisome proliferator-activated receptor α (Pparα or Ppara as listed in the MGI Database) and its downstream target, fibroblast

Article Type:
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DOI:
https://doi.org/10.1677/JOE-09-0405
Volume/Issue:
Volume 205: Issue 1
Free access
Anna G Holmes Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Jose L Mesa Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Bronwyn A Neill Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Jason Chung Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Andrew L Carey Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Gregory R Steinberg Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Bruce E Kemp Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Robert J Southgate Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Graeme I Lancaster Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Clinton R Bruce Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Matthew J Watt Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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Mark A Febbraio Diabetes and Metabolism Division, School of Medical Sciences, St Vincent's Institute and Department of Medicine, CSIRO Molecular and Health Technologies, Department of Physiology, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia

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(PPAR) γ coactivator-1 α (PGC-1α) (Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-PPARδ and anti-PPARα (Research Diagnostics, Concord, MA, USA) were obtained from Cell Signaling (Beverly, MA, USA). Plasma analysis Plasma IL-6 was measured by

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0113
Volume/Issue:
Volume 198: Issue 2
Free access
C G Walker Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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M C Sugden Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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G F Gibbons Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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M J Holness Centre for Diabetes and Metabolic Medicine, Institute of Cellular and Molecular Medicine, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford Churchill Hospital, Oxford, UK

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activation of peroxisome proliferator-activated receptor (PPAR) γ ( Guan et al. 2002 , Picard & Auwerx 2002 , Tordjman et al. 2003 , Li et al. 2005 ), a lipogenic transcription factor. Contrasting with the role of PPARγ, PPARα acts as a

Article Type:
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DOI:
https://doi.org/10.1677/JOE-06-0205
Volume/Issue:
Volume 193: Issue 1
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Alessandro Antonelli
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Silvia Martina Ferrari
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Silvia Frascerra
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Ilaria Ruffilli
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Cinzia Pupilli Department of Internal Medicine, Endocrinology Unit, Department of Otorhinolaryngology, Clinical Biochemistry Unit, School of Medicine, University of Pisa, Via Roma 67, I-56100 Pisa, Italy

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Giampaolo Bernini
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Stefano Sellari-Franceschini Department of Internal Medicine, Endocrinology Unit, Department of Otorhinolaryngology, Clinical Biochemistry Unit, School of Medicine, University of Pisa, Via Roma 67, I-56100 Pisa, Italy

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Stefania Gelmini Department of Internal Medicine, Endocrinology Unit, Department of Otorhinolaryngology, Clinical Biochemistry Unit, School of Medicine, University of Pisa, Via Roma 67, I-56100 Pisa, Italy

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Ele Ferrannini
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Poupak Fallahi
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peroxisome proliferator-activated receptors α (PPARα (PPARA)), PPARγ (PPARG), and PPARδ (PPARD) are ligand-activated nuclear receptors with a wide range of effects on metabolism, cell proliferation, and differentiation ( Michalik et al . 2006 ). In addition

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0488
Volume/Issue:
Volume 213: Issue 2
Free access
Masaya Takeda Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Fumio Otsuka Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Hiroyuki Otani Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Kenichi Inagaki Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Tomoko Miyoshi Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Jiro Suzuki Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Yukari Mimura Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Toshio Ogura Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Hirofumi Makino Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan

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Introduction Peroxisome proliferator-activated receptors (PPARs) that include PPARα , PPARβ /δ, and PPARγ belong to the family of nuclear hormone receptors, which are related to thyroid hormone, retinoic acid, androgen, and estrogen

Article Type:
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DOI:
https://doi.org/10.1677/JOE-07-0138
Volume/Issue:
Volume 194: Issue 1
Free access
Mary C Sugden Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew's and the Royal London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK

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Paul W Caton Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew's and the Royal London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK

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Mark J Holness Centre for Diabetes, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, St Bartholomew's and the Royal London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK

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by post-translation modifications (deacetylation catalyzed by the NAD + -regulated protein deacetylase SIRT) of both PPARα (PPARA as listed in the HUGO Database) and the PGC-1s, and propose that SIRT1 may lie at the heart of a regulatory loop

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0359
Volume/Issue:
Volume 204: Issue 2
Free access
Luana Lopes Souza
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Aline Cordeiro
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Lorraine Soares Oliveira
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Gabriela Silva Monteiro de Paula
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Larissa Costa Faustino
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Tania Maria Ortiga-Carvalho
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Karen Jesus Oliveira Biophysics Institute Carlos Chagas Filho, Department of Physiology and Pharmacology, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil

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Carmen Cabanelas Pazos-Moura
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metabolism genes ( Jump 2008 , Jump et al . 2008 ). The hypolipidemic effect of the FO has been explained by several mechanisms. Most of the FO effects were exerted via PPARα ( Sugiyama et al . 2008 ) and other hepatic transcriptional factors such as

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0142
Volume/Issue:
Volume 211: Issue 1
Free access