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Haiyong Chen, Hui-Yao Lan, Dimitrios H Roukos and William C Cho

2013 ). DM is a complex disease characterized by high blood glucose levels. There are two major forms of diabetes. Type 1 diabetes (T1D) results from a lack of insulin production in pancreatic β-cells. T2D is due to resistance to insulin, resulting in

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Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Chadi Pellegrini Anaruma, Marcella Ramos Sant’Ana, Thaís Dantis Pereira de Campos, Rodrigo Stellzer Gaspar, Raphael dos Santos Canciglieri, Diego Gomes de Melo, Rania A Mekary, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Pauli and Leandro Pereira de Moura

primary organs responsible for glycemic control ( Magnusson et al. 1992 , Basu et al. 2005 ), NAFLD development may be linked to obesity and type 2 diabetes (T2D). Therefore, the discovery of strategies for the prevention and treatment of excessive

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Johan G Eriksson

Type 2 diabetes Type 2 diabetes (T2D) is a major, rapidly increasing global public health challenge. The number of adults with diabetes is estimated to have increased from 108 to 422 million between 1980 and 2014 making it one of the fastest

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Rachel T Scarl, C Martin Lawrence, Hannah M Gordon and Craig S Nunemaker

reduced or abolished STEAP4 with increased insulin resistance and the pathophysiology of type 2 diabetes (T2D) ( Cheng et al. 2011 , Qin et al. 2011 ). At the whole animal level, Steap4 KO mice are prone to developing obesity, insulin resistance

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Laura B Lemke, Arlin B Rogers, Prashant R Nambiar and James G Fox

Introduction The incidence of obesity and its comorbidities – most notably metabolic syndrome, type 2 diabetes (T2D) and cardiovascular disease (CVD) – continues to increase in both adults and adolescents ( Rosenbaum et al . 2004 ). Metabolic

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Sofianos Andrikopoulos, Barbara C Fam, Anita Holdsworth, Sherley Visinoni, Zheng Ruan, Maria Stathopoulos, Anne W Thorburn, Christos N Joannides, Michael Cancilla, Lois Balmer, Joseph Proietto and Grant Morahan

Introduction Type 2 diabetes (T2D) is a complex and progressive metabolic disorder characterised by a chronic elevation of blood glucose levels. Although it is accepted that impaired insulin action is an initiating defect, hyperglycaemia only ensues

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Smithamol Sithara, Tamsyn M Crowley, Ken Walder and Kathryn Aston-Mourney

Introduction Type 2 diabetes (T2D) is an increasing problem currently affecting the health and lifestyle of more than 422 million people worldwide ( NCD-RisC 2016 ), NCD-RisC a number that is expected to rise to 592 million by 2035

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Weiwei Xu, Jamie Morford and Franck Mauvais-Jarvis

syndrome and T2D ( Stellato et al . 2000 , Oh et al . 2002 , Zitzmann 2009 , Navarro et al . 2015 ). In contrast, testosterone excess predisposes women to obesity, metabolic syndrome and T2D ( Oh et al . 2002 , Jones et al . 2011 , Navarro et al

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Craig S Nunemaker, H Grace Chung, Gretchen M Verrilli, Kathryn L Corbin, Aditi Upadhye and Poonam R Sharma

Introduction Chronic low-grade inflammation is increasingly considered as a contributing factor to many metabolic diseases including type 2 diabetes (T2D). Obesity leads to excess fatty acids and lipids in the body, which have toxic and damaging

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Kaiyuan Yang, Jonathan Gotzmann, Sharee Kuny, Hui Huang, Yves Sauvé and Catherine B Chan

Introduction Type 2 diabetes (T2D) is a metabolic disorder associated with chronic hyperglycemia and disruptions in carbo­hydrate, lipid, and protein metabolism, resulting from decreased production or altered responsiveness to insulin ( Reaven