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Tomoaki Hayakawa, Tomomi Minemura, Toshiharu Onodera, Jihoon Shin, Yosuke Okuno, Atsunori Fukuhara, Michio Otsuki and Iichiro Shimomura

syndrome and also in obese individuals ( Hirata et al . 2009 , 2012 ; Urbanet et al . 2015 ). Treatment with eplerenone, a specific MR blocker, partially reverses the obesity-associated dysfunction of adipocytes and insulin resistance in mice ( Guo et

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Olena A Fedorenko, Pawitra Pulbutr, Elin Banke, Nneoma E Akaniro-Ejim, Donna C Bentley, Charlotta S Olofsson, Sue Chan and Paul A Smith

Introduction White fat adipocytes (WFA) are the major energy depot of the body, storing and releasing energy in response to the calorific demands of the body during periods of excess and need respectively ( Arner et al. 2011 ). It is widely

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Rafaela Fadoni Alponti, Patricia Lucio Alves and Paulo Flavio Silveira

(ANG) IV receptor ( Albiston et al . 2010 ), has an important interaction with subcellular distribution of GLUT4 in adipocytes ( Jordens et al . 2010 ). IRAP is well-recognized as a companion of glucose transporter GLUT4 and a key regulator of the

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Gulizar Issa Ameen and Silvia Mora

Introduction Casitas b-lymphoma (Cbl) is a proximal insulin receptor adaptor protein identified as necessary for insulin-mediated activation of glucose transport in adipocytes ( Baumann et al . 2000 , Chiang et al . 2001 , Chang et al

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Miriam Thomalla, Andreas Schmid, Elena Neumann, Petra Ina Pfefferle, Ulf Müller-Ladner, Andreas Schäffler and Thomas Karrasch

( Schaffler et al . 2005 , 2006 , 2007 ). Obesity is associated with a significant pro-inflammatory transformation of the complex cellular environment of adipose tissue (encompassing adipocytes, pre-adipocytes, fibroblasts, monocytes, macrophages

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M Skrzypski, M Billert, K W Nowak and M Z Strowski

glucose and lipid metabolism. Orexin in adipose tissue Expression of orexin and orexin receptors in white adipose tissue Despite some inconsistencies, it appears that both OXR isoforms are present in adipocytes. While OXR1 and OXR2 were

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Noriko Tagawa, Sayaka Kubota, Ikuo Kato and Yoshiharu Kobayashi

. Recently, evidence has been accumulated that intracellular glucocorticoid amplification in adipocytes by 11β-HSD1 contributes to central obesity and, consequently, promotes metabolic diseases in experimental animals ( Masuzaki et al . 2001 ) and humans

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A Tsuchiya, T Kanno and T Nishizaki

glucose uptake into cells, and assayed Akt1/2 activity in 3T3-L1 adipocytes expressing myc-tagged GLUT4 (3T3-L1-GLUT4myc adipocytes) and under cell-free conditions. We show here that insulin stimulates GLUT4 translocation to the cell surface and increases

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Junlan Zhou, Min Cheng, Chan Boriboun, Mariam M Ardehali, Changfei Jiang, Qinghua Liu, Shuling Han, David A Goukassian, Yao-Liang Tang, Ting C Zhao, Ming Zhao, Lu Cai, Stéphane Richard, Raj Kishore and Gangjian Qin

resistance, type 2 diabetes, and cardiovascular disease ( Bornfeldt & Tabas 2011 ). In the body, white adipose tissue (WAT) is a major lipid depot that contains unilocular white adipocytes for storing vast amounts of nutrients as lipids. Brown adipose tissue

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Johanna L Barclay, Hadiya Agada, Christina Jang, Micheal Ward, Neil Wetzig and Ken K Y Ho

in weight gain and obesity. GCs increase body fat mass through several mechanisms. They stimulate the recruitment of preadipocytes to mature white adipocytes (WAs), interacting with other hormones such as insulin to activate a program of WA