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Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan
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Division of Nephrology, Wen-Lin Hemodialysis Unit, Taipei, Taiwan
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Section of Nephrology, Department of Internal Medicine, Heping Branch, Taipei City Hospital, Taipei, Taiwan
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Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
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growth factor (TGF)-β to promote renal tubulointerstitial fibrosis ( Kümpers et al . 2007 ). Adiponectin, another small peptide (30 kDa) secreted almost entirely by adipocytes, is the strongest predictor of stages 3–5 CKD according to the K
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Department of Endocrinology, Medical College, Department of Physiology, Department of Physical Education, Clinical Medical College, Yangzhou University, Nantong West Street No. 98, Yangzhou, Jiangsu 225001, China
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extracellular environment into adipocytes and myocytes ( Liang et al . 2012 ). Insulin receptor-mediated signaling cascades trigger dramatic acceleration of GLUT4 exocytosis and inhibition of its endocytosis to recruit GLUT4 onto the cell surface, resulting in
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diabetes. Three kinds of fat To date, three major types of adipose tissue have been identified. White adipose tissue (WAT) is characterized by large white adipocytes with few mitochondria, and can be found in mice predominantly around the gonads (gonadal
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Introduction Two types of UCP1 + adipocytes have been characterized by their differences in anatomic localization, developmental origin and molecular signature in rodents ( Harms & Seale 2013 , Kajimura et al. 2015 ). The classical brown
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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in weight gain and obesity. GCs increase body fat mass through several mechanisms. They stimulate the recruitment of preadipocytes to mature white adipocytes (WAs), interacting with other hormones such as insulin to activate a program of WA
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The Diabetes Institute, Ohio University, Athens, Ohio, USA
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The Diabetes Institute, Ohio University, Athens, Ohio, USA
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The Diabetes Institute, Ohio University, Athens, Ohio, USA
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within a single adipose tissue depot both BAT and WAT adipose progenitor and adipocyte populations are heterogeneous in gene expression and function. Lineage tracing analyses have also indicated that preadipocytes have different developmental sources
Department of Medicine, Faculty of Medical and Human Sciences, Department of Endocrinology, Department of Medicine, Brigham and Women's Hospital, Thorn Bldg, 1405, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
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between the adipose immune network and the stromal and adipocyte components of this tissue are only now unfolding. The two main WAT depots are the visceral (including the omentum; ∼10% of body total) and subcutaneous (∼85%) adipose tissue beds, although
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Introduction Numerous investigations have contributed to the elucidation of adipocyte differentiation. It has been proposed that adipogenesis, which comprises the whole process of adipocyte formation, consists of at least two steps
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excess energy is stored as fat in white adipose tissue (WAT). However, recent studies indicated that white adipocytes can undergo ‘beiging’ process to generate heat. The cells involved in the ‘beiging’ process, are known as beige adipocytes, have similar
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
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Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
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Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
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Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
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. In this study for the first time, we have shown the effects of hyperinsulinemia on differentiated and characterized brown adipocytes. Basal chronic hyperinsulinemia (500pM insulin exposure for 72h) causes insulin resistance in both white and brown