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Metformin increases the novel adipokine adipolin/CTRP12: role of the AMPK pathway

Bee K Tan, Jing Chen, Raghu Adya, Manjunath Ramanjaneya, Vanlata Patel, and Harpal S Randeva

/TNF-related protein (CTRP) superfamily. Adipolin (CTRP12 or FAM132A) is a novel adipokine, richly expressed by adipose tissue with insulin-sensitizing and anti-inflammatory effects ( Enomoto et al . 2011 , Wei et al . 2012 ). Indeed, lower circulating and adipose

DOI:
https://doi.org/10.1530/JOE-13-0277
Volume 219: Issue 2,
Pages:
101–108 (8 total)
Free access

Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex vivo effects

Bee K Tan, Krzysztof C Lewandowski, Joseph Paul O'Hare, and Harpal S Randeva

‘adipokines’ that are implicated in the pathogenesis of the metabolic syndrome, T2DM and cardiovascular disease ( Kershaw & Flier 2004 ). Adipolin (CTRP12) is a novel adipokine, abundantly expressed in adipose tissue, higher in subcutaneous compared with

DOI:
https://doi.org/10.1530/JOE-13-0537
Volume 221: Issue 1,
Pages:
111–119 (9 total)