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Yang Chen School of Life Science, Xuzhou Medical University, Xuzhou, Jiangsu, China
Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Xin Li School of Life Science, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Jing Zhang Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Mingjiao Zhang Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Salah Adlat Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Xiaodan Lu Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Dan Li Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Honghong Jin Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Chenhao Wang Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Zin Mar Oo Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Farooq Hayel Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Quangang Chen School of Life Science, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Xufeng Han School of Life Science, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Renjin Chen School of Life Science, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Xuechao Feng Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Luqing Zhang Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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Yaowu Zheng Transgenic Research Center, Northeast Normal University, Changchun, Jilin, China

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, aP2-VEGFB 186 , adiponectin-VEGFB 186 and VEGFB deletion mouse models were used to compare the roles of VEGFB isoforms in adipose development and function. Materials and methods All general chemicals were purchased from Sheng Gong (Shanghai

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0329
Volume/Issue:
Volume 258: Issue 1
Restricted access
Yang Chen Transgenic Research Center, Northeast Normal University, Changchun, China

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Mingyue Zhao Transgenic Research Center, Northeast Normal University, Changchun, China

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Chenhao Wang Transgenic Research Center, Northeast Normal University, Changchun, China

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Huaizhen Wen Transgenic Research Center, Northeast Normal University, Changchun, China

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Yuntao Zhang Transgenic Research Center, Northeast Normal University, Changchun, China

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Mingxu Lu Transgenic Research Center, Northeast Normal University, Changchun, China

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Salah Adlat Transgenic Research Center, Northeast Normal University, Changchun, China

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Tingting Zheng Transgenic Research Center, Northeast Normal University, Changchun, China

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Mingjiao Zhang Transgenic Research Center, Northeast Normal University, Changchun, China

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Dan Li Transgenic Research Center, Northeast Normal University, Changchun, China

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Xiaodan Lu Transgenic Research Center, Northeast Normal University, Changchun, China

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Mengwei Guo Transgenic Research Center, Northeast Normal University, Changchun, China

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Hongyu Chen Transgenic Research Center, Northeast Normal University, Changchun, China

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Luqing Zhang Transgenic Research Center, Northeast Normal University, Changchun, China
Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, China

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Xuechao Feng Transgenic Research Center, Northeast Normal University, Changchun, China
Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, China

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Yaowu Zheng Transgenic Research Center, Northeast Normal University, Changchun, China
Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, China

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whitening and BAT-associated gene downregulation ( Jin et al . 2018 ). However, the contribution of adipose-specific VEGFB expression in adipose development and energy metabolism is not clear. In this study, we have generated a mouse model with adipose

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0341
Volume/Issue:
Volume 244: Issue 3
Restricted access
Esther Dos Santos Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Marie-Noëlle Dieudonné Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Marie-Christine Leneveu Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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René Pecquery Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Valérie Serazin Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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Yves Giudicelli Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France

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adipose development and metabolism. For this purpose, we first attempted to determine whether human adipose cells express the HCG / LH-R gene. For the first time, our results reveal that both human adipocytes and their precursors express HCG

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0101
Volume/Issue:
Volume 194: Issue 2
Free access
Maria Namwanje Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Longhua Liu Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Michelle Chan Department of Biological Sciences, Columbia University, New York, New York, USA

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Nikki Aaron Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA
Department of Pharmacology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Michael J Kraakman Naomi Berrie Diabetes Center, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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Li Qiang Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

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in any of the fat depots. Though CBP and p300 tend to be considered functionally redundant, we have shown that p300 is dispensable for adipose development and brown remodeling. Figure 4 Loss of p300 has minimal effect on cold-induced brown

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0361
Volume/Issue:
Volume 240: Issue 2
Free access
Min Lu Department of Medicine, Molecular, Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, Box 1055, One Gustave L Levy Place, New York, New York 10029, USA Departments of

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Reigh-Yi Lin Department of Medicine, Molecular, Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, Box 1055, One Gustave L Levy Place, New York, New York 10029, USA Departments of
Department of Medicine, Molecular, Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, Box 1055, One Gustave L Levy Place, New York, New York 10029, USA Departments of
Department of Medicine, Molecular, Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, Box 1055, One Gustave L Levy Place, New York, New York 10029, USA Departments of
Department of Medicine, Molecular, Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, Box 1055, One Gustave L Levy Place, New York, New York 10029, USA Departments of

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investigate whether TSH directly regulates differentiation of the earliest stages of adipose development. Murine ES cells are pluripotent stem cell lines isolated from the inner cell mass of 3.5-day blastocysts that can be propagated indefinitely in an

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0452
Volume/Issue:
Volume 196: Issue 1
Free access
B Beck INSERM, Université Henri Poincaré, U954, Nutrition, Génétique et Exposition aux Risques Environnementaux, Faculté de Médecine, BP 184, F-54505 Vandoeuvre Cedex, France
INSERM, Université Henri Poincaré, U954, Nutrition, Génétique et Exposition aux Risques Environnementaux, Faculté de Médecine, BP 184, F-54505 Vandoeuvre Cedex, France

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S Richy INSERM, Université Henri Poincaré, U954, Nutrition, Génétique et Exposition aux Risques Environnementaux, Faculté de Médecine, BP 184, F-54505 Vandoeuvre Cedex, France

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reported in obese subjects after restriction. The Zucker fa/fa rat is a widely used animal model of obesity with hyperinsulinemia and hypertriglyceridemia ( Bray 1977 ). It is also characterized by the down-regulation of ghrelin in order to limit adiposity

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0080
Volume/Issue:
Volume 202: Issue 1
Free access
Michael E Symonds Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Mark Pope Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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Ian Bloor Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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James Law Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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Reham Alagal Department of Physical Sport Science, Princess Nourah Bint AbdulRahman University, Riyadh, Saudi Arabia

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Helen Budge Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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‘healthy’ male cadaver aged 22 years ( de Jong et al. 2019 ). Thus careful consideration of cross-species age matching may be fundamental for informative future rodent modelling of adipose development and adaptation. Taken together these types of findings

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0075
Volume/Issue:
Volume 248: Issue 1
Free access
Jillian L Rourke Department of Pharmacology, Faculty of Medicine, Dalhousie University, 5850 College Street, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2

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Shanmugam Muruganandan Department of Pharmacology, Faculty of Medicine, Dalhousie University, 5850 College Street, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2

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Helen J Dranse Department of Pharmacology, Faculty of Medicine, Dalhousie University, 5850 College Street, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2

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Nichole M McMullen Department of Pharmacology, Faculty of Medicine, Dalhousie University, 5850 College Street, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2

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Christopher J Sinal Department of Pharmacology, Faculty of Medicine, Dalhousie University, 5850 College Street, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2

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mice had normal body weight, adipose development, and tissue inflammation. However, loss of Gpr1 resulted in exacerbation of HFD-induced glucose intolerance, elevated blood glucose following a pyruvate challenge, and reduced glucose

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0069
Volume/Issue:
Volume 222: Issue 2
Free access
Antonio Gonzalez-Bulnes
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Susana Astiz
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Cristina Ovilo Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Clemente J Lopez-Bote Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Raul Sanchez-Sanchez
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Maria L Perez-Solana
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Laura Torres-Rovira Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Miriam Ayuso Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Jorge Gonzalez Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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undernutrition or overnutrition induces higher body corpulence and adiposity, development of metabolic syndrome and the prodrome of type-2 diabetes in the first generation of descendants ( Barbero et al . 2013 ). The objective of this study was to determine the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0217
Volume/Issue:
Volume 223: Issue 1
Free access
Koichiro Taguchi Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Kazuo Kajita Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Yoshihiko Kitada Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Masayuki Fuwa Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Motochika Asano Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Takahide Ikeda Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Toshiko Kajita Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Tatsuo Ishizuka Department of General Internal Medicine and Rheumatology, Gifu Municipal Hospital, Gifu, Japan

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Itaru Kojima Laboratory of Cell Physiology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan

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Hiroyuki Morita Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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white and beige adipocytes . Development 145 dev155861 . ( https://doi.org/10.1242/dev.155861 ) Gulyaeva O Dempersmier J Sul HS 2018 Genetic and epigenetic control of adipose development . BBA - Molecular and Cell Biology of Lipids

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0503
Volume/Issue:
Volume 245: Issue 1
Open access