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Changjie Han, Yan Jiao, Qingguo Zhao and Baisong Lu

mice show growth retardation associated with IGF1 deficiency in developing bones ( Jiao et al . 2012 a ), and reduced adiposity due to increased energy expenditure ( Jiao et al . 2012 b ). Herein, we further examined the effects of Mex3c mutation on

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F J Steyn, T Y Xie, L Huang, S T Ngo, J D Veldhuis, M J Waters and C Chen

, is associated with improved metabolism, maintenance of healthy body composition, and improved quality of life ( Jorgensen et al . 2011 , Park et al . 2011 ). Conversely, GH deficiency is associated with increased adiposity, reduced bone mass, and

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Tristan S Allemann, Gursimran K Dhamrait, Naomi J Fleury, Tamara N Abel, Prue H Hart, Robyn M Lucas, Vance B Matthews and Shelley Gorman

endothelial function ( Maiorana et al . 2003 ). Physical activity may promote metabolic health in other ways by improving the functional capacity of brown adipose tissue (BAT). As part of an early response to exercise, BAT secretes the ‘lipokine’ 12

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Ricardo J Samms, Michelle Murphy, Maxine J Fowler, Scott Cooper, Paul Emmerson, Tamer Coskun, Andrew C Adams, Alexei Kharitonenkov, Francis J P Ebling and Kostas Tsintzas

adiposity, which can be experimentally induced via a change in photoperiod to increase or decrease appetite and body weight ( Ebling 2014 ). Their summer state is induced by long day lengths and is characterized by increased adiposity coupled with leptin

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Liping Luo and Meilian Liu

Introduction Adipose tissue, which is primarily composed of adipocytes as well as pre-adipocytes, macrophages, endothelial cells, fibroblasts, and leucocytes, has been increasingly recognized as a major player of systemically metabolic

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Carsten T Herz and Florian W Kiefer

Adipose tissue browning and whitening A hallmark feature of adipose tissue browning is the induction of thermogenically active adipocytes in white fat depots. These adipocytes are often referred to as beige or brite (brown in white) cells and

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Vitaly Ablamunits, Simon Klebanov, Sharon Y Giese and Kevan C Herold

Introduction A growing evidence indicates that white adipose tissue (WAT) is an important endocrine organ secreting a number of factors collectively known as adipokines. Some of these factors, such as leptin ( Zhang et al . 1994 ) and adiponectin

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Mark A Exley, Laura Hand, Donal O'Shea and Lydia Lynch

Adipose tissue as an immune organ Immune organs represent sites of exclusive immunological function; however, the definition of an immune tissue has been extended to organs such as the liver ( Doherty & O'Farrelly 2000 ), uterus ( Lynch et al

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Yang Chen, Mingyue Zhao, Chenhao Wang, Huaizhen Wen, Yuntao Zhang, Mingxu Lu, Salah Adlat, Tingting Zheng, Mingjiao Zhang, Dan Li, Xiaodan Lu, Mengwei Guo, Hongyu Chen, Luqing Zhang, Xuechao Feng and Yaowu Zheng

Introduction Obesity, an epidemic and chronic disease induced by excessive energy storage and adipose expansion, affects millions of people ( Kopelman 2000 , WHO Expert Consultation 2004 , James 2008 ). An imbalanced energy intake and

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Junlan Zhou, Min Cheng, Chan Boriboun, Mariam M Ardehali, Changfei Jiang, Qinghua Liu, Shuling Han, David A Goukassian, Yao-Liang Tang, Ting C Zhao, Ming Zhao, Lu Cai, Stéphane Richard, Raj Kishore and Gangjian Qin

resistance, type 2 diabetes, and cardiovascular disease ( Bornfeldt & Tabas 2011 ). In the body, white adipose tissue (WAT) is a major lipid depot that contains unilocular white adipocytes for storing vast amounts of nutrients as lipids. Brown adipose tissue