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Daniela Fernandois Department of Biochemistry and Molecular Biology, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile

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Gonzalo Cruz Laboratorio de Alteraciones Reproductivas y Metabólicas, Centro de Neurobiología y Plasticidad Cerebral (CNPC), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile

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Eun Kyung Na Department of Biochemistry and Molecular Biology, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile

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Hernán E Lara Department of Biochemistry and Molecular Biology, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile

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Alfonso H Paredes Department of Biochemistry and Molecular Biology, Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile

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effort to explain this difference, we found that the increase in sympathetic activity in the ovaries of aged rats shows a correlation with an increase in Kisspeptin (KISS1) expression in the ovary ( Fernandois et al . 2016 ). Surprisingly, in in vitro

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0181
Volume/Issue:
Volume 232: Issue 1
Free access
Yoshinori Kanemaru Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Norio Harada Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Satoko Shimazu-Kuwahara Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, Kyoto, Japan

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Shunsuke Yamane Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Eri Ikeguchi Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Yuki Murata Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Sakura Kiyobayashi Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Tomonobu Hatoko Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Nobuya Inagaki Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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Introduction Life expectancy has increased in developed countries and is accompanied by the main age-related changes in body composition, which are an increase in fat mass and a decrease in muscle mass. In addition, visceral fat accumulation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0477
Volume/Issue:
Volume 245: Issue 1
Open access
Pegah JafariNasabian Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida, USA

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Julia E Inglis Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida, USA

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Wendimere Reilly Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida, USA

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Owen J Kelly Abbott Nutrition, Columbus, Ohio

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Jasminka Z Ilich Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida, USA

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Introduction As a result of increased life expectancy, the demographics of aging is rapidly changing. Accordingly, it is predicted that the number of people older than 65 years in the United States will double by 2030, reaching approximately

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0603
Volume/Issue:
Volume 234: Issue 1
Free access
Renata C Uliani Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil

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Alan J Conley Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA

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C Jo Corbin Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA

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Aimê M Friso Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil

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Luciana F S Maciel Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil

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Marco A Alvarenga Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil

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Introduction Anti-Müllerian hormone (AMH) has attracted considerable interest in female reproduction as an indicator of reproductive aging and fertility, predicting the size of follicle populations in the ovaries of women and other mammals

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0391
Volume/Issue:
Volume 240: Issue 2
Free access
Christine A Beamish Lawson Health Research Institute, St Joseph Health Care, London, Ontario, Canada
Department of Physiology & Pharmacology, Western University, London, Ontario, Canada

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Sofia Mehta Lawson Health Research Institute, St Joseph Health Care, London, Ontario, Canada

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Brenda J Strutt Lawson Health Research Institute, St Joseph Health Care, London, Ontario, Canada

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Subrata Chakrabarti Lawson Health Research Institute, St Joseph Health Care, London, Ontario, Canada
Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada

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Manami Hara Department of Medicine, University of Chicago, Chicago, Illinois, USA

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David J Hill Lawson Health Research Institute, St Joseph Health Care, London, Ontario, Canada
Department of Physiology & Pharmacology, Western University, London, Ontario, Canada
Department of Medicine, Western University, London, Ontario, Canada

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. 2004 , Seaberg et al. 2004 , Nir et al. 2007 , Teta et al. 2007 , Xu et al. 2008 , Van de Casteele et al. 2013 ), especially as the tissue origins of new β cells may differ with age ( Solar et al. 2009 , Salpeter et al. 2010

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0475
Volume/Issue:
Volume 233: Issue 3
Free access
Yu Zhou Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Min Gong Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Yingfei Lu Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Jianquan Chen Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Rong Ju Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Introduction Polycystic ovary syndrome (PCOS), which affects 6–20% of reproductive-age women worldwide, is considered the most common cause of infertility ( Dumesic et al. 2015 ). In addition to reproductive system disorders, it is also

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0129
Volume/Issue:
Volume 251: Issue 1
Restricted access
M K Judge Department of Pharmacology and Therapeutics, Department of Veterans Affairs Medical Center, Department of Aging and Geriatrics, College of Medicine, University of Florida, PO Box 100267, Gainesville, Florida 32610, USA

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Y Zhang Department of Pharmacology and Therapeutics, Department of Veterans Affairs Medical Center, Department of Aging and Geriatrics, College of Medicine, University of Florida, PO Box 100267, Gainesville, Florida 32610, USA
Department of Pharmacology and Therapeutics, Department of Veterans Affairs Medical Center, Department of Aging and Geriatrics, College of Medicine, University of Florida, PO Box 100267, Gainesville, Florida 32610, USA

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P J Scarpace Department of Pharmacology and Therapeutics, Department of Veterans Affairs Medical Center, Department of Aging and Geriatrics, College of Medicine, University of Florida, PO Box 100267, Gainesville, Florida 32610, USA
Department of Pharmacology and Therapeutics, Department of Veterans Affairs Medical Center, Department of Aging and Geriatrics, College of Medicine, University of Florida, PO Box 100267, Gainesville, Florida 32610, USA

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demonstrated that this normalization, at least partially, is leptin dependent, and thus, prolonged in leptin-resistant rats ( Zhang et al . 2007 ). Moreover, this hyperphagia is heightened and prolonged in aged rats who also display leptin resistance ( Judge

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0210
Volume/Issue:
Volume 203: Issue 2
Free access
Paramita M Ghosh Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Zhen-Ju Shu Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Bing Zhu Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Zhongding Lu Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Yuji Ikeno Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of
Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Jeffrey L Barnes Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Chih-Ko Yeh Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of
Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of
Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Bin-Xian Zhang Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of
Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Michael S Katz Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of
Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of
Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Amrita Kamat Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of
Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of
Geriatric Research, Medicine, Comprehensive Dentistry, Barshop Institute for Longevity and Aging Studies, Education and Clinical Center (182), Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA Departments of

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Introduction The metabolic syndrome comprises a number of related disorders including obesity, insulin resistance, type 2 diabetes, and cardiovascular disease ( Ford et al . 2002 , Dowman et al . 2011 ). Aging is considered to be a risk factor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0406
Volume/Issue:
Volume 213: Issue 3
Free access
Sandra Zárate Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Buenos Aires, Argentina
Departamento de Histología, Embriología, Biología Celular y Genética, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

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Mariana Astiz Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP, UNLP-CONICET) and Cátedra de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Nacional de La Plata, La Plata, Argentina

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Natalia Magnani Instituto de Bioquímica y Medicina Molecular (IBIMOL, UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina

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Mercedes Imsen Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Buenos Aires, Argentina

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Florencia Merino Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Buenos Aires, Argentina

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Silvia Álvarez Instituto de Bioquímica y Medicina Molecular (IBIMOL, UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina

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Analía Reinés Instituto de Biología Celular y Neurociencias ‘Prof. E. De Robertis’ (IBCN, UBA-CONICET), Facultad de Medicina and Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina

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Adriana Seilicovich Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Buenos Aires, Argentina
Departamento de Histología, Embriología, Biología Celular y Genética, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

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brain aging ( Chakrabarti et al. 2011 ). Aging is an inevitable biological process characterized by a progressive decline in physiological functions and increased susceptibility to disease. It is now accepted that normal aging and several aging

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0451
Volume/Issue:
Volume 233: Issue 1
Free access
Russell T Turner Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA
Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Michael Dube Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Adam J Branscum Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Carmen P Wong Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Dawn A Olson Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Xiaoying Zhong Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Mercedes F Kweh Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Iske V Larkin Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Thomas J Wronski Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Clifford J Rosen Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Satya P Kalra Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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Urszula T Iwaniec Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA
Skeletal Biology Laboratory, Center for Healthy Aging Research, Department of Neuroscience, Biostatistics, Department of Physiological Sciences, Department of Large Animal Clinical Sciences, Maine Medical Center Research Institute, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon 97331, USA

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this approach can induce weight loss and/or maintain lower body weight in aging rodents with normal circulating levels of the hormone ( Shapiro et al . 2008 ). In humans, calorie restriction-induced weight loss is often associated with bone loss

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0280
Volume/Issue:
Volume 227: Issue 3
Free access