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Takuya Yoshino, Tomohisa Nagoshi, Ryuko Anzawa, Yusuke Kashiwagi, Keiichi Ito, Daisuke Katoh, Masami Fujisaki, Yosuke Kayama, Taro Date, Kenichi Hongo and Michihiro Yoshimura

Introduction Aldosterone plays a pivotal role in the pathophysiology of cardiovascular diseases. There is increasing evidence of unfavorable effects of aldosterone on the cardiovascular system, in experimental models as well as large clinical trials

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Ding Xie and Wendy B Bollag

been proposed including increased sympathetic nervous system activity, overactivation of the renin-angiotensin II-aldosterone system, excessive secretion of adipose-derived cytokines, inflammation and compression of the kidneys by excess perirenal fat

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Yuefei Huang, Pei Yee Ting, Tham M Yao, Tsuyoshi Homma, Danielle Brooks, Isis Katayama Rangel, Gail K Adler, Jose R Romero, Jonathan S Williams, Luminita H Pojoga and Gordon H Williams

salt intake ( Carvalho et al . 1989 ). A major regulator of sodium/volume homeostasis is aldosterone ( Ehrhart-Bornstein et al . 1998 , Lumbers 1999 , Spat & Hunyady 2004 , Williams 2005 ). For more than a half-a-century, it has been known that

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Cherish Chong, Anis Hamid, Tham Yao, Amanda E Garza, Luminita H Pojoga, Gail K Adler, Jose R Romero and Gordon H Williams

Introduction Aldosterone, a major regulator of electrolyte balance and body-fluid homeostasis, is produced by the zona glomerulosa (ZG) of the adrenal cortex ( Giroud et al. 1956 ). Aldosterone’s production is regulated at early (cholesterol

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Timothy J Cole and Morag J Young

Introduction The mineralocorticoid receptor (MR) is an intracellular steroid hormone receptor, and a member of the nuclear receptor superfamily, that mediates the physiological action of two important adrenal steroids, aldosterone and cortisol

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John M C Connell and Eleanor Davies

Introduction It is now over 50 years since Sylvia and James Tait, in collaboration with Tadeusz Reichstein, isolated and characterized the steroid hormone, aldosterone ( Tait et al. 2004 ). Since then, the traditional view has been

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Achim Lother, Lisa Deng, Michael Huck, David Fürst, Jessica Kowalski, Jennifer S Esser, Martin Moser, Christoph Bode and Lutz Hein

Introduction Aldosterone mediates its effects via the mineralocorticoid receptor (MR), a ligand-activated transcription factor. Upon binding of aldosterone, MR interacts with a distinct DNA motif to regulate transcription of its target genes

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Maria-Christina Zennaro and Fabio Fernandes-Rosa

Introduction Aldosterone and the mineralocorticoid receptor (MR) play a key role in the regulation of electrolyte balance and blood pressure. Abnormalities in aldosterone and MR function lead to salt-losing disorders or hypertension

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Ying-Ying Tsai, William E Rainey and Wendy B Bollag

Introduction Aldosterone is the primary mineralocorticoid hormone involved in maintaining fluid and electrolyte balance through its control of sodium and potassium homeostasis, thereby regulating blood volume and pressure under physiological

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Stephan Werth, Helge Müller-Fielitz and Walter Raasch

Introduction The Framingham Offspring Study suggested that increased abdominal fat mass accounts for 65–75% of the risk for hypertension ( Garrison et al. 1987 ). Among other hormonal systems, the renin–angiotensin–aldosterone system (RAAS