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Hong Ma, Jin Yuan, Jinyu Ma, Jie Ding, Weiwei Lin, Xinlei Wang, Mingliang Zhang, Yi Sun, Runze Wu, Chun Liu, Cheng Sun and Yunjuan Gu

free of such side effects are urgently needed to cure the increasing number of T2D patients. Bone morphogenetic protein 7 (BMP7), a member of the transforming growth factor-β (TGF-β) family, has been reported to induce the conversion of white adipose

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Alison Mostyn, Linda Attig, Thibaut Larcher, Samir Dou, Pascale Chavatte-Palmer, Monia Boukthir, Arieh Gertler, Jean Djiane, Michael E Symonds and Latifa Abdennebi-Najar

-3′ Cyclooxygenase 2 ( COX2 ) AF207824.1 F: 5′-TCCGACAGCCAAAGACACTCAAG-3′ R: 5′-TTATGTTCCCGCAGCCAGATTGTG-3′ Bone morphogenetic protein 7 ( BMP7 ) NM_001105290.1 F: 5′-CATGGTCATGAGCTTCGTCAAC-3′ R: 5′-GTCCTTGTAGATGCGGAATTCAGC-3′ Uncoupling protein 1

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Mina Takahashi, Fumio Otsuka, Tomoko Miyoshi, Hiroyuki Otani, Junko Goto, Misuzu Yamashita, Toshio Ogura, Hirofumi Makino and Hiroyoshi Doihara

Tetsuro Watabe and Kohei Miyazono for providing Id-1-Luc plasmid. References Alarmo EL Rauta J Kauraniemi P Karhu R Kuukasjarvi T Kallioniemi A 2006 Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer . Genes

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Jorge N Artaza and Keith C Norris

.32 Col12α1 Procollagen, type XI I,α1 −1.87 −2.89 Col14α1 Procollagen, type XIV,α1 −1.56 −2.5 Fst Follistatin +6.56 +7.82 BMP7 Bone morphogenetic protein 7 +4.21 +6.35 MMP8 Matrix metalloproteinase 8 +3.46 +5.35 Cultures of C3H 10T1/2 cells were treated as

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Claire Glister, Nigel P Groome and Philip G Knight

CF, Lang E & Patel K 2002 Follistatin regulates bone morphogenetic protein-7 (BMP-7) activity to stimulate embryonic muscle growth. Developmental Biology 243 115 –127. Campbell BK , Scaramuzzi RJ & Webb R 1996

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Ola Nilsson, Elizabeth A Parker, Anita Hegde, Michael Chau, Kevin M Barnes and Jeffrey Baron

morphogenetic protein-2. Endocrinology 142 430 –436. Haaijman A , Karperien M, Lanske B, Hendriks J, Lowik CW, Bronckers AL & Burger EH 1999 Inhibition of terminal chondrocyte differentiation by bone morphogenetic protein 7 (OP

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J R V Silva, T Tharasanit, M A M Taverne, G C van der Weijden, R R Santos, J R Figueiredo and R van den Hurk

. Lee WS , Yoon SJ, Yoon TK, Cha KY, Lee SH, Shimasaki S, Lee S & Lee KA 2004 Effects of bone morphogenetic protein-7 (BMP-7) on primordial follicular growth in the mouse ovary. Molecular Reproduction and Development 69 159 –163

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M-O Faure, L Nicol, S Fabre, J Fontaine, N Mohoric, A McNeilly and C Taragnat

development. Animal Reproduction Sciences 78 165 –183. Lee WS , Otsuka F, Moore RK & Shimasaki S 2001 Effect of bone morphogenetic protein-7 on folliculogenesis and ovulation in the rat. Biology of reproduction 65 994

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Z H Liu, K Tsuchida, T Matsuzaki, Y L Bao, A Kurisaki and H Sugino

morphogenetic protein 7 (BMP-7). Direct binding of these ligands to ActRIIs promotes the recruitment of type I receptors to the complex, which in turn results in phosphorylation of type I receptors, activation of type I receptors, and downstream propagation of

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Abdoulaye Diané, Nikolina Nikolic, Alexander P Rudecki, Shannon M King, Drew J Bowie and Sarah L Gray

Taniguchi CM Tran TT Suzuki R Espinoza DO Yamamoto Y 2008 New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure . Nature 454 1000 – 1004 . ( doi:10.1038/nature07221 ) Uchida Y Kano M Yasuhara S