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Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK
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( Shahinian et al. 2005 ). However, the effects of these drugs on the cardiovascular system are less well understood. This relationship merits discussion given the diverse utilisation of GnRH analogues across the lifespan and gender spectrum, and high
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known for over 20 years, yet no function has been attributed to it. The cardiovascular system is emerging as a potential site for AMH action. High levels of AMH associate with the absence of cardiovascular disease in elderly men ( Chong et al . 2013
Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia
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Cardiovascular Endocrinology, Department of Physiology, MIMR-PHI Institute, 27–31 Wright St, Clayton 3168, Australia
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-absorption and, by doing so, has direct effects on potassium and magnesium secretion and chloride re-absorption ( Crabbe 1963 , Wright & Giebisch 1978 ). Aldosterone also has profound effects on the cardiovascular system, altering gene expression and influencing
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, IVRT) were not significantly affected by dexamethasone. There was no effect of dexamethasone on the MDI in SMGRKO fetuses. In an adult population with a high prevalence of hypertension and diabetes but free of prevalent cardiovascular disease, MDI
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Mineralocorticoid receptor signaling and cardiovascular disease While classically described as regulators of sodium and volume homeostasis in the kidney, aldosterone, and its receptor – the mineralocorticoid receptor (MR) – are increasingly
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-renal tissues. Over the past several decades, it has become evident that MR is also expressed in the vasculature, with roles in regulating vascular function and contributing to cardiovascular physiology and pathophysiology. Investigation into the role of MR in
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pregnancy with high blood pressure. Introduction Pregnancy represents a unique physiological challenge. Essentially all organ systems are affected, including the cardiovascular, metabolic, immunological, gastrointestinal and neurological systems
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and an increased risk of cardiovascular mortality. Thus, testosterone, the male gonadal hormone primarily known for its classical role in reproduction, becomes a hormone of metabolic and cardiovascular significance. However, our understanding of the
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Introduction It is well established that patients with metabolic diseases, in particular insulin resistance and type 2 diabetes mellitus (T2DM), are more than twice as likely to develop accelerated cardiovascular disease (CVD) including
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Department of Medicine, Case Cardiovascular Institute Research Institute, Case Western Reserve University, Cleveland, OH, USA
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Sex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan
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Introduction Globally, cardiovascular diseases (CVDs) are still the highest cause of death worldwide in developed countries and developing countries ( Gaziano et al . 2010 ). Several risk factors, including smoking, diabetes, and
