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Laboratory for Reproductive Health, Palo Alto Institute for Research and Education, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
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Introduction Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), was initially identified as a chemoattractant ligand for the G protein-coupled receptor (GPR), chemokine-like receptor 1 (CMKLR1, also known as ChemR23 or DEZ
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Introduction Adipokines, secreted by adipose tissue, are involved in the pathogenesis of metabolic syndrome ( Lehr et al . 2012 ). Chemerin, encoded by the gene retinoic acid receptor responder 2 ( Rarres2 ), also known as tazarotene
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Introduction Chemerin, also known as retinoic acid receptor responder (tazarotene-induced) 2, is a hormone-like protein that is secreted by the liver and white adipose tissue (WAT) as well as at localized sites of inflammation ( Goralski et al
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University of Chinese Academy of Sciences, Shenzhen, China
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Introduction Chemerin, a recently discovered adipose cytokine, is also known as tazarotene-induced gene 2 ( TIG2 ) and retinoic acid receptor responder protein 2 (RARRES2) ( Zabel et al . 2006 ). Initially, chemerin was considered to be a
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chemical mediators, termed adipocytokines or adipokines. The discovery of leptin in 1994 heralded a new era in the study of WAT and the discovery of a number of adipocytokines, such as adiponectin, leptin, resistin, visfatin, apelin, omentin, chemerin
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Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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family ( Maffei et al . 1995 , Hu et al . 1996 ), but several new members have been discovered recently ( MacDougald & Burant 2007 , Wozniak et al . 2009 , Ouchi et al . 2011 ), and since 2007, chemerin has been included in this family of
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1 , Tnfα and chemerin. Il6 mRNA concentrations were dose-dependently decreased by up to 60% after stimulation with dexamethasone for 8 h ( Fig. 2 A). Furthermore, the inhibitory effect of dexamethasone was time-dependent. Il6 gene expression was
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Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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3rd Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
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Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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2nd Internal Department, 3rd Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic
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Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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classical adipokines including adiponectin and leptin, several other adipokines were examined in the context of GDM. One of these adipokines is chemerin, which is involved in the regulation of adipocyte development and liver, skeletal muscle and adipose
Division of Metabolic and Vascular Health, Warwickshire Institute for the Study of Diabetes, Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital Site, University of Warwick, Coventry CV2 2DX, UK
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Division of Metabolic and Vascular Health, Warwickshire Institute for the Study of Diabetes, Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital Site, University of Warwick, Coventry CV2 2DX, UK
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/PBEF/NAMPT Pro-inflammatory and insulin mimicking Secreted by adipocytes ↑ In obesity Chang et al . (2011) and McGee et al . (2011) Chemerin Affects adipogenesis, inflammation as well as glucose metabolism Secreted by WAT ↑ In obesity Catalán et al . (2011
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
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al. 2015 ), angiotensinogen ( Campbell & Habener 1987 ), and chemerin ( Hansen et al. 2014 ). Other previously identified brown adipokines such as fibroblast growth factor-21 (FGF21), neuregulin-4 (NRG4) or bone morphogenetic protein-8b (BMP8b