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Juan P Zúñiga-Hertz Department of Physiology and Biophysics, Department of Anesthesiology, Helmy Institute for Medical Sciences, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508‐000 São Paulo, Brazil
Department of Physiology and Biophysics, Department of Anesthesiology, Helmy Institute for Medical Sciences, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508‐000 São Paulo, Brazil

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Eduardo Rebelato Department of Physiology and Biophysics, Department of Anesthesiology, Helmy Institute for Medical Sciences, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508‐000 São Paulo, Brazil

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Adam Kassan Department of Physiology and Biophysics, Department of Anesthesiology, Helmy Institute for Medical Sciences, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508‐000 São Paulo, Brazil

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Abdelrahman M Khalifa Department of Physiology and Biophysics, Department of Anesthesiology, Helmy Institute for Medical Sciences, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508‐000 São Paulo, Brazil

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Sameh S Ali Department of Physiology and Biophysics, Department of Anesthesiology, Helmy Institute for Medical Sciences, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508‐000 São Paulo, Brazil
Department of Physiology and Biophysics, Department of Anesthesiology, Helmy Institute for Medical Sciences, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508‐000 São Paulo, Brazil

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Hemal H Patel Department of Physiology and Biophysics, Department of Anesthesiology, Helmy Institute for Medical Sciences, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508‐000 São Paulo, Brazil

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Fernando Abdulkader Department of Physiology and Biophysics, Department of Anesthesiology, Helmy Institute for Medical Sciences, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508‐000 São Paulo, Brazil

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biochemical processes and molecules may influence its efficiency, including products of cholesterol biosynthesis. The rate-limiting step in the cholesterol biosynthesis pathway is catalyzed by hydroxymethylglutaryl-CoA (HMGCoA) reductase, which is inhibited by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0348
Volume/Issue:
Volume 224: Issue 1
Free access
Nan Yang Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Giorgio Caratti Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Louise M Ince Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Toryn M Poolman Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Peter J Trebble Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Cathy M Holt Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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David W Ray Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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Laura C Matthews Manchester Centre for Nuclear Hormone Research in Disease and Institute of Human Development, Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK

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through serum-response factor ( Gerber et al . 2013 ). Herein, we define the role of serum components on regulating Gc sensitivity. We identify cholesterol as a critical Gc regulatory serum component, and also that activation of JNKs and AP1 is essential

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0456
Volume/Issue:
Volume 223: Issue 2
Open access
Satoko Haeno Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine

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Naoyuki Maeda Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine
Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine

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Takeshi Yagi Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine

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Sachi Tahata Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine

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Michiko Sato Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine

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Kanako Sakaguchi Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine

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Taku Miyasho Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine

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Hiromi Ueda Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine

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Hiroshi Yokota Laboratory of Veterinary Biochemistry, Laboratory of Veterinary Pathology, Laboratory of Veterinary Anatomy, Laboratory Animal Nutrition, Japan Meat Science and Technology Institute, School of Veterinary Medicine

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Analyzer ver 3.0 (ATTO). Enzymatic activity assay of cholesterol side chain cleavage reaction Enzymatic activities were assayed as described previously ( Maeda et al . 2013 b ) using a 20-hydroxycholesterol as a substrate, and the reaction product

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0460
Volume/Issue:
Volume 221: Issue 2
Free access
Amanda J Genders Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia
Institute for Health and Sport (iHeS), Victoria University, Melbourne, Victoria, Australia

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Timothy Connor Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia

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Shona Morrison Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia

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Simon T Bond Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia
Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Brian G Drew Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Peter J Meikle Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Kirsten F Howlett Institute for Physical Activity and Nutrition (IPAN) and School of Exercise and Nutrition Science and Deakin University, Geelong, Victoria, Australia

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Sean L McGee Institute for Mental and Physical Health and Clinical Translation (iMPACT) and Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia

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on glucose homeostasis in response to fasting and refeeding, despite the reduced expression of gluconeogenic genes in both the fasted and refed state. Expression of DN PKD also reduced circulating LDL/VLDL cholesterol and enhanced pyruvate tolerance

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0548
Volume/Issue:
Volume 246: Issue 3
Restricted access
Prasanthi P Koganti Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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Amy H Zhao Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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Vimal Selvaraj Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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Introduction Steroid hormone biosynthesis starts with cholesterol as a substrate. Bioconversion of cholesterol to the first steroid precursor, pregnenolone ( Lynn Jr. et al. 1955 , Saba & Hechter 1955 , Staple et al. 1956 ), by CYP11A1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0043
Volume/Issue:
Volume 254: Issue 3
Restricted access
Aldo Grefhorst Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Johanna C van den Beukel Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Wieneke Dijk Division of Human Nutrition, Nutrition, Metabolism, and Genomics Group, Wageningen University, Wageningen, The Netherlands

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Jacobie Steenbergen Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Gardi J Voortman Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Selmar Leeuwenburgh Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Theo J Visser Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Sander Kersten Division of Human Nutrition, Nutrition, Metabolism, and Genomics Group, Wageningen University, Wageningen, The Netherlands

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Edith C H Friesema Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Axel P N Themmen Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Jenny A Visser Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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( Bartelt et al. 2011 , Khedoe et al. 2015 ). Recently, it has been shown that cold exposure also affects whole-body cholesterol metabolism, for instance by inducing the reverse cholesterol transport by HDL particles ( Bartelt et al. 2017 ) and by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0076
Volume/Issue:
Volume 238: Issue 2
Free access
Giselle Adriana Abruzzese Laboratorio de Fisio-Patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Maria Florencia Heber Laboratorio de Fisio-Patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Silvana Rocío Ferreira Laboratorio de Fisio-Patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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María José Ferrer Laboratorio de Fisio-Patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Alicia Beatriz Motta Laboratorio de Fisio-Patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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participate directly in the steroidogenic process, in which cholesterol acts as the limiting substratum in ovarian steroid synthesis ( van Montfoort et al. 2014 ). Moreover, regarding steroidogenesis, cholesterol availability is a determinant for hormone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0304
Volume/Issue:
Volume 247: Issue 3
Restricted access
Lihong Fu Shanghai National Research Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yixuan Qiu Shanghai National Research Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Linyan Shen Shanghai National Research Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, China

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Canqi Cui Shanghai National Research Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Shuang Wang BGI Genomics, BGI-Shenzhen, Shenzhen, China

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Shujie Wang Shanghai National Research Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yun Xie Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xinjie Zhao Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China

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Xianfu Gao Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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Guang Ning Shanghai National Research Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Aifang Nie Shanghai National Research Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yanyun Gu Shanghai National Research Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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increased BW gain and cholesterol levels after abx withdrawing. The decreased Bacteroides and increased Firmicutes were manifested as the gut microbiota dysbiosis after abx cessation and correlated with increased fecal taurine BAs and decreased odd carbon

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0709
Volume/Issue:
Volume 238: Issue 2
Free access
Nawal A Yahya Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA

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Steven R King Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

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Bo Shi Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA

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Aisha Shaaban Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA

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Nicole E Whitfield Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA

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Chunmei Yan Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA
Department of Obstetrics, The Second Hospital of Shandong University, Jinan, Shandong, People’s Republic of China

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Richard J Kordus Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA

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Gail F Whitman-Elia Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA

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Holly A LaVoie Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA

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Introduction Cholesterol serves many essential functions systemically and within cells. This is especially true for the ovary, in which the somatic cells of the developing follicle, under the influence of follicle-stimulating hormone (FSH) and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0385
Volume/Issue:
Volume 262: Issue 2
Restricted access
Affiong Ika Oqua Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Yusman Manchanda Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Emma Rose McGlone Department of Surgery and Cancer, Imperial College London, London, UK

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Ben Jones Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Sarah Rouse Department of Life Sciences, Imperial College, London, UK

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Alejandra Tomas Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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the effect that lipids have on GPCR function, with cholesterol specifically acting as an allosteric modulator ( Oates & Watts 2011 , Kumar & Chattopadhyay 2021 , Yeliseev et al . 2021 , Baccouch et al . 2022 ). However, much of the work done to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0335
Volume/Issue:
Volume 261: Issue 3
Open access