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Huanan Zhang School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Yantai University, Yantai, China
Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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John R Speakman Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
Institute of Health Sciences, China Medical University, Shenyang, Liaoning, China

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Introduction The first coffee was apparently consumed in what is modern-day Yemen about 600–700 years ago. One story of its origin is that a sheikh was exiled from the city of Mokha on the Red Sea coast ( Ukers 1935 ). Feeling hungry, he found

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Bo He Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China
School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China

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Yinxian Wen Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China

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Shuwei Hu Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China

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Guihua Wang Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China

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Wen Hu Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China

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Jacques Magdalou UMR 7561 CNRS-Université de Lorraine, Faculté de Médicine, Vandoeuvre-lès-Nancy, Nancy, France

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Liaobin Chen Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China
Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China

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Hui Wang Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China
Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China

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Introduction Caffeine is a xanthine alkaloid that is widely present in coffee, tea, soft drink beverages, food and some analgesic drugs, making it one of the most frequently ingested psychoactive substances worldwide ( Brent et al. 2011

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Maik Pietzner Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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Tim Kacprowski Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan Technical University of Munich, Freising-Weihenstephan, Germany

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Nele Friedrich Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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metabolites and 500 spectral bins) TSH: 4 (all inversely)FT 4 : 5 (1 positively) Gluconeogenesis from amino acids (upregulated)Dimethylamine production (downregulated)Coffee intake (positive with FT 4 ) Alanine concentrations were predictive for changes

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Ken Kubota Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

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Toshiro Kubota Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

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Daisuke Kamei Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

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Makoto Murakami Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

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Ichiro Kudo Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

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Takeshi Aso Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

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Ikuo Morita Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Comprehensive Reproductive Medicine, Tokyo Medical and Dental University, 1-5–45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5–8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

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mice lacking microsomal prostaglandin e synthase-1. Journal of Biological Chemistry 279 33684 –33695. Kennedy CR , Zhang Y, Brandon S, Guan Y, Coffee K, Funk CD, Magnuson MA, Oates JA, Breyer MD & Breyer RM 1999 Salt

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R H Straub
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L B Tankó Laboratory of Neuroendocrino-Immunology, Center for Clinical and Basic Research, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany

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C Christiansen Laboratory of Neuroendocrino-Immunology, Center for Clinical and Basic Research, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany

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P J Larsen Laboratory of Neuroendocrino-Immunology, Center for Clinical and Basic Research, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany

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D S Jessop Laboratory of Neuroendocrino-Immunology, Center for Clinical and Basic Research, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany

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. Information about traditional cardiovascular factors were recorded: BMI, blood pressure, smoking habits, daily coffee consumption, regular alcohol consumption, and weekly physical activities of at least 1 h duration per occasion (1, none; 2, once; 3, twice; 4

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Michael E Symonds Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK

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Mark Pope Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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Ian Bloor Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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James Law Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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Reham Alagal Department of Physical Sport Science, Princess Nourah Bint AbdulRahman University, Riyadh, Saudi Arabia

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Helen Budge Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK

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similar effects in increasing BAT-dependent energy expenditure as does cold exposure ( Luo et al. 2012 ). Caffeine (1,3,7-trimethylxantine), a widely consumed plant alkaloid found in coffee, and tea has been shown to aid weight loss and increased energy

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Johan Svensson Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden
Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden

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Åsa Tivesten Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden
Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden

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Klara Sjögren Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden
Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden

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Olle Isaksson Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden
Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden

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Göran Bergström Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden
Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden

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Subburaman Mohan Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden
Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden

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Johan Mölne Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden
Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden

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Jörgen Isgaard Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden
Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden

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Claes Ohlsson Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden
Department of Clinical Physiology, Göteborg University, Göteborg, Sweden
Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden

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-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clinical

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V L Clifton Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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R Crompton Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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M A Read Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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P G Gibson Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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R Smith Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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I M R Wright Mothers and Babies Research Center, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Neonatal Intensive Care Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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coffee and food for at least 1 h before the investigation. Drugs Synthetic human CRH was obtained from Auspep (Melbourne, Australia). Acetylcholine chloride was obtained from the Sigma Chemical Company

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Mark O Huising Department of Animal Physiology, Institute for Neuroscience, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Cell Biology and Immunology, Wageningen University, Wageningen, The Netherlands

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Corine P Kruiswijk Department of Animal Physiology, Institute for Neuroscience, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Cell Biology and Immunology, Wageningen University, Wageningen, The Netherlands

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Gert Flik Department of Animal Physiology, Institute for Neuroscience, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Department of Cell Biology and Immunology, Wageningen University, Wageningen, The Netherlands

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cytokines, non-mammalian orthologs have been identified to date. The amino acid sequence alignment obtained by T-Coffee ( Notredame et al. 2000 ) was refined by hand to correct for overt alignment mismatches. Phylogenetic analysis of such a large number

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You-Hua Xu Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China

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Chen-Lin Gao Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
Department of Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

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Heng-Li Guo Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China

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Wen-Qian Zhang Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China

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Wei Huang Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
Department of Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

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Shan-Shan Tang Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China

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Wen-Jun Gan Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China

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Yong Xu Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
Department of Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

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Hua Zhou Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China

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Quan Zhu Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China

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Spent coffee grounds, an innovative source of colonic fermentable compounds, inhibit inflammatory mediators in vitro . Food Chemistry 212 282 – 290 . ( https://doi.org/10.1016/j.foodchem.2016.05.175 ) 10.1016/j.foodchem.2016.05.175 27374534 Lu

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