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Vikte Lionikaite, Karin L Gustafsson, Anna Westerlund, Sara H Windahl, Antti Koskela, Juha Tuukkanen, Helena Johansson, Claes Ohlsson, H Herschel Conaway, Petra Henning and Ulf H Lerner

, induces cortical bone loss in long bones of rats ( Trechsel et al. 1987 , Hough et al. 1988 , Johansson et al. 2002 , Kneissel et al. 2005 , Lind et al. 2011 , 2013 , Wray et al. 2011 ) and mice ( Kneissel et al. 2005 ), which is

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Toshihiro Sugiyama, Toshiaki Takaki, Kenya Sakanaka, Hiroki Sadamaru, Koji Mori, Yoshihiko Kato, Toshihiko Taguchi and Takashi Saito

and strength ( Ehrlich & Lanyon 2002 ). For example, mechanical load-induced expansion of cortical bone structure effectively restricts skeletal fragility; however, such a structural change cannot be detected properly as areal BMD. Considering that

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Donlaporn Kittivanichkul, Narattaphol Charoenphandhu, Phisit Khemawoot and Suchinda Malaivijitnond

). Therefore, women in this postmenopausal period of life have 15% cortical bone loss (Khosla 2013), with cortical bone fractures being the most frequent. At present, many scientists have tried to search for new chemicals to mitigate bone loss and improve

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Claes Ohlsson, Petra Henning, Karin H Nilsson, Jianyao Wu, Karin L Gustafsson, Klara Sjögren, Anna Törnqvist, Antti Koskela, Fu-Ping Zhang, Marie K Lagerquist, Matti Poutanen, Juha Tuukkanen, Ulf H Lerner and Sofia Movérare-Skrtic

Introduction Osteoporosis affects hundreds of millions of people worldwide and fragility fractures cause enormous problems particularly for postmenopausal women and older men ( Baron & Hesse 2012 ). Cortical bone is a key determinant of bone

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Thomas Funck-Brentano, Karin H Nilsson, Robert Brommage, Petra Henning, Ulf H Lerner, Antti Koskela, Juha Tuukkanen, Martine Cohen-Solal, Sofia Movérare-Skrtic and Claes Ohlsson

by the identification of genetic variants in the WNT machinery that were responsible for rare diseases with either low or high bone mass ( Baron & Kneissel 2013 ). Moreover, we previously identified WNT16 as a major contributor of cortical bone

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Viji Vijayan and Sarika Gupta

mice were left to habituate to new cage environment ( Bundgaard et al . 2012 ). Though young, the mice at week 10 showed calcified borders as evidenced by MicroCT50 ( Fig. 1A ). Figure 1 Changes in femoral cortical bone geometry upon HHCY. (A

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Helen E MacLean, Alison J Moore, Stephen A Sastra, Howard A Morris, Ali Ghasem-Zadeh, Kesha Rana, Anna-Maree Axell, Amanda J Notini, David J Handelsman, Ego Seeman, Jeffrey D Zajac and Rachel A Davey

tomography slices of the mid-femoral diaphysis were acquired using 10.5 μm isotropic voxel size. Cortical bone properties were evaluated in a region commencing 56% of the femur length distal to the femoral head and extending 0.5 mm distally. Images were

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Yongmei Wang, Takeshi Sakata, Hashem Z Elalieh, Scott J Munson, Andrew Burghardt, Sharmila Majumdar, Bernard P Halloran and Daniel D Bikle

containing the TFJ was digitized with a Hamamatsu video camera (Carl Zeiss Inc, Thornwood, NY, USA) coupled to a Leica DMR microscope, and periosteal MAR, BFR, single labeling surface of endosteal surface, cortical bone area and medullary area were determined

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K L Gustafsson, K H Nilsson, H H Farman, A Andersson, V Lionikaite, P Henning, J Wu, S H Windahl, U Islander, S Movérare-Skrtic, K Sjögren, H Carlsten, J-Å Gustafsson, C Ohlsson and M K Lagerquist

’s protocol. Real-time PCR RNA was isolated from hypothalamus, fat, muscle and bone marrow from long bones (tibia and femur) using the RNeasy Mini Kit (Qiagen). RNA from cortical bone was isolated using TRIzol reagent (Sigma) followed by the RNeasy

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Filip Callewaert, Mieke Sinnesael, Evelien Gielen, Steven Boonen and Dirk Vanderschueren

compared to boys. As a result, men not only build up wider bones but also stronger bones, with cortical bone further away from the neutral axis of the long bone and more resistant to bending. Sex hormones have traditionally been considered the primary