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Karsten Suhre

body, as they are revealed by studies of metabolic profiling in diabetes ( German et al . 2005 , Wenk 2005 ). Application of metabolomics approaches to metabolic disorders, especially diabetes, is particularly promising since deregulations of

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Haiyong Chen, Hui-Yao Lan, Dimitrios H Roukos and William C Cho

Introduction Diabetes mellitus (DM) affects 347 million people worldwide. The World Health Organization predicts that diabetes-related deaths could double between 2005 and 2030. The research conducted by American Diabetes Association estimated that

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Johan G Eriksson

Type 2 diabetes Type 2 diabetes (T2D) is a major, rapidly increasing global public health challenge. The number of adults with diabetes is estimated to have increased from 108 to 422 million between 1980 and 2014 making it one of the fastest

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Elizabeth S Barrie, Mels Lodder, Paul H Weinreb, Jill Buss, Amer Rajab, Christopher Adin, Qing-Sheng Mi and Gregg A Hadley

Introduction Type 1 diabetes is a T cell-mediated autoimmune disease caused by the destruction of insulin-producing β cells of the islets of Langerhans in the pancreas, resulting in a hyperglycemic state. Non-obese diabetic (NOD) mice (NOD

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Che-Pei Kung and Maureen E Murphy

diabetes. Structure and function of the p53 tumor-suppressor protein p53 protein is made of 393 amino acids and uses a zinc-coordinated DNA-binding domain to bind in a sequence-specific manner to DNA consensus elements that contain two copies of the

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Richard W Nelson and Claudia E Reusch

Introduction Diabetes mellitus is a common disorder in dogs and cats, with a reported hospital prevalence rate of ∼0.4–1.2%. Classic clinical signs of diabetes include polyuria, polydipsia, polyphagia, and weight loss. Clinical signs do not develop

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Hao Wu, Junduo Wu, Shengzhu Zhou, Wenlin Huang, Ying Li, Huan Zhang, Junnan Wang and Ye Jia

Introduction Macrovascular complications develop in >50% of the diabetic patients and result in high mortality ( King & Wakasaki 1999 , Forbes et al . 2004 ). Given the dramatic increase in the prevalence of diabetes mellitus (DM

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John N Stabley, Rhonda D Prisby, Bradley J Behnke and Michael D Delp

Introduction The increase in fracture risk observed among patients with type 2 diabetes mellitus (T2DM) has been suggested to be associated with corollaries of the disease, such as peripheral neuropathy, decreased physical fitness, vision loss, and

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Mohammed Bensellam, Jean-Christophe Jonas and D Ross Laybutt

animal and human studies suggest that mature β-cells could regress backwards to a precursor-like stage and/or transdifferentiate into other islet cells in type 2 diabetes. Interestingly, cellular differentiation is not unidirectional. Indeed

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Yolanda Diz-Chaves, Manuel Gil-Lozano, Laura Toba, Juan Fandiño, Hugo Ogando, Lucas C González-Matías and Federico Mallo

nervous system (SNS) activation, favours the accumulation of visceral fat and contributes to the clinical presentation of visceral obesity, type 2 diabetes mellitus (DM2) and related cardiometabolic complications. In addition, both circulating and local