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Karsten Suhre

body, as they are revealed by studies of metabolic profiling in diabetes ( German et al . 2005 , Wenk 2005 ). Application of metabolomics approaches to metabolic disorders, especially diabetes, is particularly promising since deregulations of

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Haiyong Chen, Hui-Yao Lan, Dimitrios H Roukos and William C Cho

Introduction Diabetes mellitus (DM) affects 347 million people worldwide. The World Health Organization predicts that diabetes-related deaths could double between 2005 and 2030. The research conducted by American Diabetes Association estimated that

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Elizabeth S Barrie, Mels Lodder, Paul H Weinreb, Jill Buss, Amer Rajab, Christopher Adin, Qing-Sheng Mi and Gregg A Hadley

Introduction Type 1 diabetes is a T cell-mediated autoimmune disease caused by the destruction of insulin-producing β cells of the islets of Langerhans in the pancreas, resulting in a hyperglycemic state. Non-obese diabetic (NOD) mice (NOD

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Che-Pei Kung and Maureen E Murphy

diabetes. Structure and function of the p53 tumor-suppressor protein p53 protein is made of 393 amino acids and uses a zinc-coordinated DNA-binding domain to bind in a sequence-specific manner to DNA consensus elements that contain two copies of the

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Richard W Nelson and Claudia E Reusch

Introduction Diabetes mellitus is a common disorder in dogs and cats, with a reported hospital prevalence rate of ∼0.4–1.2%. Classic clinical signs of diabetes include polyuria, polydipsia, polyphagia, and weight loss. Clinical signs do not develop

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Hao Wu, Junduo Wu, Shengzhu Zhou, Wenlin Huang, Ying Li, Huan Zhang, Junnan Wang and Ye Jia

Introduction Macrovascular complications develop in >50% of the diabetic patients and result in high mortality ( King & Wakasaki 1999 , Forbes et al . 2004 ). Given the dramatic increase in the prevalence of diabetes mellitus (DM

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John N Stabley, Rhonda D Prisby, Bradley J Behnke and Michael D Delp

Introduction The increase in fracture risk observed among patients with type 2 diabetes mellitus (T2DM) has been suggested to be associated with corollaries of the disease, such as peripheral neuropathy, decreased physical fitness, vision loss, and

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Mohammed Bensellam, Jean-Christophe Jonas and D Ross Laybutt

animal and human studies suggest that mature β-cells could regress backwards to a precursor-like stage and/or transdifferentiate into other islet cells in type 2 diabetes. Interestingly, cellular differentiation is not unidirectional. Indeed

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Yolanda Diz-Chaves, Manuel Gil-Lozano, Laura Toba, Juan Fandiño, Hugo Ogando, Lucas C González-Matías and Federico Mallo

nervous system (SNS) activation, favours the accumulation of visceral fat and contributes to the clinical presentation of visceral obesity, type 2 diabetes mellitus (DM2) and related cardiometabolic complications. In addition, both circulating and local

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Louis Potier, Ludovic Waeckel, Fréderic Fumeron, Sophie Bodin, Marinos Fysekidis, Catherine Chollet, Naima Bellili, Fabrice Bonnet, Gaëlle Gusto, Gilberto Velho, Michel Marre, François Alhenc-Gelas, Ronan Roussel, Nadine Bouby and the DESIR study group

obesity-related disorders have provided encouraging but still limited results ( Satterfield et al . 2003 , Laatikainen et al . 2007 ). The pathogenesis of insulin resistance and diabetes in obesity is complex and still incompletely understood. Besides