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School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
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Introduction Diabetic nephropathy (DN), referred to chronic kidney disease (CKD) caused by diabetes mellitus ( Möllsten et al. 2007 ), affects approximately 30% of diabetic patients ( Parving et al. 2006 , Thomas et al. 2006 , Nathan
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Introduction Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide ( ADA 2014 ), accounting for nearly half of all causes of renal failure despite the currently available therapy. It is characterized by glomerular
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Introduction The rapid onset of obesity is one of the main causes of insulin resistance and diabetic complications, such as retinopathy, neuropathy, cardiovascular disease and diabetic nephropathy (DN), which are associated with elevated
Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China
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Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China
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Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China
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Introduction Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus, accounting for almost 50% of all end-stage renal disease cases. Renal fibrosis is a major characteristic of DN and an important predictor of renal
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Glycation and Diabetes Group, Mater Clinical School, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, South Brisbane, Queensland, Australia
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prevalence of kidney disease ( Rajapurkar et al . 2012 ). It has also been observed that South Indian/Asian migrants have a greater prevalence and faster progression of diabetic nephropathy (DN) when compared with their European counterparts ( Samanta et al
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number of people with diabetes worldwide will increase from 382 million in 2013 to 592 million by 2035, according to the International Diabetes Federation ( Shi & Hu 2014 ). Diabetic nephropathy (DN) is one of the most devastating complications of
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IGF1 in promoting matrix production and proliferation of kidney cells ( Horney et al . 1998 , Lupia et al . 1999 ) prompted us to investigate the role of PAPP-A in the development of diabetic nephropathy, the leading cause of end-stage renal disease
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Introduction Diabetic nephropathy is now the most common cause of end-stage renal disease (ESRD), which significantly contributes to the high mortality in type II diabetic patients ( Ruggenenti & Remuzzi 1998 ). It is projected that 30–40% of
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Introduction Diabetic nephropathy is one of the most serious micro-vascular complications. The diabetic milieu results in the increased expression of angiogenic growth factors in numerous tissues in response to both hyperglycemia and
Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
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Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China
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Introduction As one of the long-term complications of diabetes, diabetic nephropathy (DN) is the main cause of end-stage renal disease ( Dronavalli et al . 2008 ). Thus, end-stage renal disease cannot be effectively prevented or treated