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Jia Sun of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China

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Haiping Zhu of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Xiaorong Wang of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Qiuqi Gao of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Zhuoying Li of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Huiya Huang of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

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Introduction Diabetic nephropathy (DN), referred to chronic kidney disease (CKD) caused by diabetes mellitus ( Möllsten et al. 2007 ), affects approximately 30% of diabetic patients ( Parving et al. 2006 , Thomas et al. 2006 , Nathan

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Diane Donegan Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA

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Laurie K Bale Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA

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Cheryl A Conover Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA

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Introduction Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide ( ADA 2014 ), accounting for nearly half of all causes of renal failure despite the currently available therapy. It is characterized by glomerular

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Eun Soo Lee Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea

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Mi-Hye Kwon The East Coast Research Institute of Life Science, Gangneung-Wonju National University, Gangneung, Korea

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Hong Min Kim Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea

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Nami Kim Department of Anatomy, Korea University College of Medicine, Seoul, Korea

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You Mi Kim Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea

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Hyeon Soo Kim Department of Anatomy, Korea University College of Medicine, Seoul, Korea

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Eun Young Lee Department of Internal Medicine and Institute of Tissue Regeneration, Soonchunhyang University, Cheonan, Korea

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Choon Hee Chung Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea

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Introduction The rapid onset of obesity is one of the main causes of insulin resistance and diabetic complications, such as retinopathy, neuropathy, cardiovascular disease and diabetic nephropathy (DN), which are associated with elevated

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Weixia Han Department of Pathology, Hebei Medical University, Shijiazhuang, China
Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China

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Chen Wang Department of Pathology, Second Hospital, Shanxi Medical University, Taiyuan, China

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Zhifen Yang Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Lin Mu Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Ming Wu Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Nan Chen Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Chunyang Du Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Huijun Duan Department of Pathology, Hebei Medical University, Shijiazhuang, China
Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China

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Yonghong Shi Department of Pathology, Hebei Medical University, Shijiazhuang, China
Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China

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Introduction Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus, accounting for almost 50% of all end-stage renal disease cases. Renal fibrosis is a major characteristic of DN and an important predictor of renal

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Aowen Zhuang Glycation and Diabetes Group, Mater Clinical School, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, South Brisbane, Queensland, Australia

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Josephine M Forbes Glycation and Diabetes Group, Mater Clinical School, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, South Brisbane, Queensland, Australia
Glycation and Diabetes Group, Mater Clinical School, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, South Brisbane, Queensland, Australia

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prevalence of kidney disease ( Rajapurkar et al . 2012 ). It has also been observed that South Indian/Asian migrants have a greater prevalence and faster progression of diabetic nephropathy (DN) when compared with their European counterparts ( Samanta et al

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Yan Ding Division of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, 525 East 68th Street, Box 3, New York, New York 10065, USA

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Mary E Choi Division of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, 525 East 68th Street, Box 3, New York, New York 10065, USA

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number of people with diabetes worldwide will increase from 382 million in 2013 to 592 million by 2035, according to the International Diabetes Federation ( Shi & Hu 2014 ). Diabetic nephropathy (DN) is one of the most devastating complications of

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Jessica R Mader
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Zachary T Resch
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Gary R McLean Endocrine Research Unit, Department of Comparative Medicine, Cellular and Molecular Immunology Research Centre, Department of Molecular Biology and Genetics, Division of Endocrinology, Mayo Clinic, 200 First Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Jakob H Mikkelsen Endocrine Research Unit, Department of Comparative Medicine, Cellular and Molecular Immunology Research Centre, Department of Molecular Biology and Genetics, Division of Endocrinology, Mayo Clinic, 200 First Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Claus Oxvig Endocrine Research Unit, Department of Comparative Medicine, Cellular and Molecular Immunology Research Centre, Department of Molecular Biology and Genetics, Division of Endocrinology, Mayo Clinic, 200 First Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Ronald J Marler Endocrine Research Unit, Department of Comparative Medicine, Cellular and Molecular Immunology Research Centre, Department of Molecular Biology and Genetics, Division of Endocrinology, Mayo Clinic, 200 First Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA

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Cheryl A Conover
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IGF1 in promoting matrix production and proliferation of kidney cells ( Horney et al . 1998 , Lupia et al . 1999 ) prompted us to investigate the role of PAPP-A in the development of diabetic nephropathy, the leading cause of end-stage renal disease

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Yi Lin Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA

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Zhongjie Sun Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA

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Introduction Diabetic nephropathy is now the most common cause of end-stage renal disease (ESRD), which significantly contributes to the high mortality in type II diabetic patients ( Ruggenenti & Remuzzi 1998 ). It is projected that 30–40% of

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Dae Ryong Cha
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Young Sun Kang
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Sang Youb Han
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Yi Hwa Jee
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Kum Hyun Han
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Jee Young Han
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Young Sik Kim
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Nan Hee Kim
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Introduction Diabetic nephropathy is one of the most serious micro-vascular complications. The diabetic milieu results in the increased expression of angiogenic growth factors in numerous tissues in response to both hyperglycemia and

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Wenpeng Dong Dialysis Center, Daqing Oilfield General Hospital, Daqing, Heilongjiang, People’s Republic of China
Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Ye Jia Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Xiuxia Liu Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Huan Zhang Operating theatre, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Tie Li Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Wenlin Huang School of Science and Technology, Georgia Gwinnett College, Lawrenceville, Georgia, USA

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Xudong Chen Gastroenterology Department No. 1, Jilin Central General Hospital, Jilin, Jilin, People’s Republic of China

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Fuchun Wang Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Weixia Sun Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Hao Wu Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Introduction As one of the long-term complications of diabetes, diabetic nephropathy (DN) is the main cause of end-stage renal disease ( Dronavalli et al . 2008 ). Thus, end-stage renal disease cannot be effectively prevented or treated

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