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Atsuya Tsuru Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

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Mikihiro Yoshie Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

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Mei Suzuki Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

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Hiroki Mochizuki Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

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Satoshi Kametaka Division of Biofunctional Sciences, Department of Integrated Health Sciences, Graduate School of Medicine, Nagoya University, Aichi, Japan

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Takako Ohmaru-Nakanishi Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Mana Azumi Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

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Kazuya Kusama Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

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Kiyoko Kato Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Kazuhiro Tamura Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

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multinuclear syncytiotrophoblasts (STs). Formation of the multinucleated ST layer via fusion of CTs is referred to as syncytialization, which is a well-characterized morphological sign of terminal differentiation. STs function not only as the placental barrier

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0163
Volume/Issue:
Volume 260: Issue 2
Restricted access
Diego Safian Reproductive Biology Group, Division Developmental Biology, Institute of Biodynamics and Biocomplexity, Department of Biology , Faculty of Science, University of Utrecht, Utrecht, The Netherlands

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Jan Bogerd Reproductive Biology Group, Division Developmental Biology, Institute of Biodynamics and Biocomplexity, Department of Biology , Faculty of Science, University of Utrecht, Utrecht, The Netherlands

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Rüdiger W Schulz Reproductive Biology Group, Division Developmental Biology, Institute of Biodynamics and Biocomplexity, Department of Biology , Faculty of Science, University of Utrecht, Utrecht, The Netherlands
Reproduction and Developmental Biology Group, Institute of Marine Research, Nordnes, Bergen, Norway

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proliferate either to self-renew thereby producing more SSCs or undergo a differentiating proliferation to eventually produce spermatozoa. A balanced self-renewal/differentiation activity is critical to maintain long-term spermatogenesis and testis tissue

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0124
Volume/Issue:
Volume 238: Issue 3
Free access
Diego Crespo Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands

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Moline Severino Lemos Laboratory of Cell Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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Yu Ting Zhang State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Fujian, People’s Republic of China
Institute of Oceanography, Minjiang University, Fuzhou, People’s Republic of China

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Diego Safian Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands

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Birgitta Norberg Institute of Marine Research, Austevoll Research Station, Storebø, Norway

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Jan Bogerd Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands

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Rüdiger W Schulz Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands
Research Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway

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early life-stage during zebrafish sex differentiation, it is interesting to note that PGD 2 resulted in male-biased, PGE 2 in female-biased sex ratios ( Pradhan & Olsson 2014 ). However, we are not aware of studies on the role of PGs in adult

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0309
Volume/Issue:
Volume 244: Issue 1
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Diego Safian Reproductive Biology Group, Division Developmental Biology, Department of Biology, Institute of Biodynamics and Biocomplexity, Faculty of Science, University of Utrecht, NL-3584 CH Utrecht, The Netherlands

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Najoua Ryane Reproductive Biology Group, Division Developmental Biology, Department of Biology, Institute of Biodynamics and Biocomplexity, Faculty of Science, University of Utrecht, NL-3584 CH Utrecht, The Netherlands

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Jan Bogerd Reproductive Biology Group, Division Developmental Biology, Department of Biology, Institute of Biodynamics and Biocomplexity, Faculty of Science, University of Utrecht, NL-3584 CH Utrecht, The Netherlands

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Rüdiger W Schulz Reproductive Biology Group, Division Developmental Biology, Department of Biology, Institute of Biodynamics and Biocomplexity, Faculty of Science, University of Utrecht, NL-3584 CH Utrecht, The Netherlands
Reproduction and Developmental Biology Group, Institute of Marine Research, Nordnes, Bergen, Norway

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differentiating daughter cells committed to develop into spermatozoa ( De Rooij 2017 ). In fish, as in all vertebrates, SSCs form part of the population of type A und spermatogonia ( Lacerda et al. 2010 , Nóbrega et al. 2010 , Sato et al. 2017 ). In fish

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0447
Volume/Issue:
Volume 239: Issue 3
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Alan Conley Department of Population Health & Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA

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Ned J Place Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA

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Erin L Legacki Department of Population Health & Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA

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Geoff L Hammond Department of Cellular & Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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Gerald R Cunha Department of Urology, University of California, San Francisco, California, USA

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Christine M Drea Departments of Evolutionary Anthropology and Biology, Duke University, Durham, North Carolina, USA

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Mary L Weldele Departments of Psychology and Integrative Biology, University of California, Berkeley, California, USA

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Steve E Glickman Departments of Psychology and Integrative Biology, University of California, Berkeley, California, USA

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( Watson 1877 , Matthews 1939 ). Female elephants also have a long urogenital canal ( Perry 1964 , Balke et al. 1988 ) and a well-developed clitoris which is difficult to differentiate grossly from the flaccid penis of the bull elephant ( Perry 1964

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0252
Volume/Issue:
Volume 247: Issue 1
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AnneMarie Gagnon Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6
Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6

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Charlie Foster Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6
Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6

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Anne Landry Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6
Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6

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Alexander Sorisky Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6
Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6

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activate pro-inflammatory intracellular signaling molecules, such as inhibitor of κB kinase β (IKKβ), that can block the adipocyte differentiation program ( Gregoire et al . 1998 , Tanti & Jager 2009 ). IKKβ is also activated in human preadipocytes by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0565
Volume/Issue:
Volume 217: Issue 2
Free access
Eva Baquedano Department of Pediatrics, Department of Endocrinology, Centro de Investigación Biomédica en Red de fisiopatología de la obesidad y nutrición (CIBERobn), Universidad Autónoma de Madrid, Madrid, Spain
Department of Pediatrics, Department of Endocrinology, Centro de Investigación Biomédica en Red de fisiopatología de la obesidad y nutrición (CIBERobn), Universidad Autónoma de Madrid, Madrid, Spain

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Julie A Chowen Department of Pediatrics, Department of Endocrinology, Centro de Investigación Biomédica en Red de fisiopatología de la obesidad y nutrición (CIBERobn), Universidad Autónoma de Madrid, Madrid, Spain
Department of Pediatrics, Department of Endocrinology, Centro de Investigación Biomédica en Red de fisiopatología de la obesidad y nutrición (CIBERobn), Universidad Autónoma de Madrid, Madrid, Spain

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Jesús Argente Department of Pediatrics, Department of Endocrinology, Centro de Investigación Biomédica en Red de fisiopatología de la obesidad y nutrición (CIBERobn), Universidad Autónoma de Madrid, Madrid, Spain
Department of Pediatrics, Department of Endocrinology, Centro de Investigación Biomédica en Red de fisiopatología de la obesidad y nutrición (CIBERobn), Universidad Autónoma de Madrid, Madrid, Spain
Department of Pediatrics, Department of Endocrinology, Centro de Investigación Biomédica en Red de fisiopatología de la obesidad y nutrición (CIBERobn), Universidad Autónoma de Madrid, Madrid, Spain

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Laura M Frago Department of Pediatrics, Department of Endocrinology, Centro de Investigación Biomédica en Red de fisiopatología de la obesidad y nutrición (CIBERobn), Universidad Autónoma de Madrid, Madrid, Spain
Department of Pediatrics, Department of Endocrinology, Centro de Investigación Biomédica en Red de fisiopatología de la obesidad y nutrición (CIBERobn), Universidad Autónoma de Madrid, Madrid, Spain

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of mitosis, cell proliferation and differentiation ( Frago et al . 2002 , Ajo et al . 2003 ). Binding of GH to its receptor mediates many of its effects through activation of the JAK/STAT signalling pathway ( Lanning & Carter-Su 2006 ); however

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0053
Volume/Issue:
Volume 218: Issue 3
Free access
Y Kamei Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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Y Aoyama Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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T Fujimoto Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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N Kenmotsu Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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C Kishi Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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M Koushi Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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S Sugano Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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K Morohashi Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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R Kamiyama Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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R Asakai Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyouku, Tokyo, Japan
Laboratory of Functional Genomics, Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo, Japan
Division for Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama 5-1, Myondaiji-cho, Okazaki, Japan

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Introduction Granulosa cells (GC) are committed to differentiation under the control of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which transmit signals mainly through cAMP signaling. The stimulated GC can

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05718
Volume/Issue:
Volume 185: Issue 1
Free access
Sujith Rajan Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Kripa Shankar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Muheeb Beg Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Salil Varshney Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Abhishek Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Ankita Srivastava Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Durgesh Kumar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Raj K Mishra SIPS Superspeciality Hospital, Lucknow, Uttar Pradesh, India

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Zakir Hussain Division of Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Jiaur R Gayen Division of Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Anil N Gaikwad Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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. In this study for the first time, we have shown the effects of hyperinsulinemia on differentiated and characterized brown adipocytes. Basal chronic hyperinsulinemia (500pM insulin exposure for 72h) causes insulin resistance in both white and brown

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0099
Volume/Issue:
Volume 230: Issue 3
Free access
C Mogi
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H Goda
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K Mogi
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A Takaki
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K Yokoyama
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M Tomida
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K Inoue
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cells are considered to arise from a common precursor cell, and the sequential expression of transcription factors involved in pituitary organogenesis induces differentiation into different endocrine cells. Pituitary endocrine cell development and the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05870
Volume/Issue:
Volume 184: Issue 1
Free access