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Stephen G Matthews Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Departments of Obstetrics & Gynaecology and Medicine, University of Toronto, Toronto, Ontario, Canada
Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

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Patrick O McGowan Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Department of Biological Sciences and Center for Environmental Epigenetics and Development, University of Toronto, Scarborough, Ontario, Canada
Department of Cell and Systems Biology, Department of Psychology, University of Toronto, Toronto, Ontario, Canada

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studies ( Sasaki et al. 2013 , Hamada & Matthews 2019 ). Several genes associated with the regulation of HPA function and related behaviours are susceptible to altered epigenetic modulation. These findings suggest that epigenetic mechanisms represent a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0057
Volume/Issue:
Volume 242: Issue 1
Free access
Irving Salinas Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan
Department of Physiology, Michigan State University, East Lansing, Michigan, USA

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Niharika Sinha Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan
Department of Animal Sciences, Michigan State University, East Lansing, Michigan, USA

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Aritro Sen Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan
Department of Animal Sciences, Michigan State University, East Lansing, Michigan, USA

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). Interestingly, emerging evidence suggests that steroid hormones may also influence or alter gene expression through epigenetic modifications ( Matsumoto et al . 2013 ). Control of gene expression occurs at different levels, one of which is the accessibility of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0578
Volume/Issue:
Volume 249: Issue 3
Free access
Celia Siu Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
Department of Sciences, University of British Columbia, Vancouver, Canada

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Sam Wiseman Department of Surgery, St. Paul’s Hospital & University of British Columbia, Vancouver, Canada

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Sitanshu Gakkhar Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada

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Alireza Heravi-Moussavi Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada

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Misha Bilenky Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada

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Annaick Carles Department of Microbiology & Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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Thomas Sierocinski Department of Microbiology & Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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Angela Tam Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada

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Eric Zhao Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada

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Katayoon Kasaian Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada

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Richard A Moore Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada

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Andrew J Mungall Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada

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Blair Walker Department of Pathology and Laboratory Medicine, St. Paul’s Hospital & University of British Columbia, Vancouver, Canada

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Thomas Thomson Department of Pathology and Laboratory Medicine, BC Cancer Agency & University of British Columbia, Vancouver, Canada

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Marco A Marra Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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Martin Hirst Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
Department of Microbiology & Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, Canada

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Steven J M Jones Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
Department of Medical Genetics, University of British Columbia, Vancouver, Canada
Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, Canada

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glands. The result is that accurate assessment of abnormal thyroid states across individuals is challenging. One way to study thyroid function is to examine the epigenetics involved in the regulation of thyroid gene expression and transcription

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0145
Volume/Issue:
Volume 235: Issue 2
Free access
Miguel A Velazquez School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK

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Tom P Fleming Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK

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Adam J Watkins Division of Child Health, Obstetrics and Gynaecology, Faculty of Medicine, University of Nottingham, Nottingham, UK

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across physiological, cellular, molecular and epigenetic levels. Much progress on the understanding of the hypothesis, now known as the developmental origins of health and adult disease (DOHaD) concept, has been achieved as evidenced by the varied reviews

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0676
Volume/Issue:
Volume 242: Issue 1
Free access
Ivana Vaněčková Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Lenka Maletínská Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Michal Behuliak Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Veronika Nagelová Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Josef Zicha Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Jaroslav Kuneš Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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epigenetics. These non-genetic alterations, which have an important regulatory action in modifying gene expression in response to environmental stimuli, are under the control of two major epigenetic mechanisms: methylation of cytosine residues of DNA and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0368
Volume/Issue:
Volume 223: Issue 3
Free access
Arturo Hernandez Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, Maine, USA
Graduate School for Biomedical Science and Engineering, University of Maine, Orono, Maine, USA
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA

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M Elena Martinez Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, Maine, USA

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). Reproduction not only implies the accurate transmission of the genetic code to the next generation. Sperm can carry a wealth of non-genetic (epigenetic) information that reflects the variable environmental and pathophysiological circumstances of an individual

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0550
Volume/Issue:
Volume 244: Issue 3
Free access
Dipali Goyal School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA

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Sean W Limesand School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA

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Ravi Goyal School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA

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, illustrating endocrine-related epigenetic changes due to maternal stress. Thus, changes in placental hormone initiate mechanisms that initiate a cascade of events that cause fetal growth restriction and may result in developmental programming. Of note

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0009
Volume/Issue:
Volume 242: Issue 1
Free access
Kimberley C W Wang Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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Kimberley J Botting Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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Song Zhang Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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I Caroline McMillen Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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Doug A Brooks Mechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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Janna L Morrison Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

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moderated by epigenetic mechanisms, such as DNA methylation, histone acetylation and microRNA (miR), which will be discussed later in this review. Furthermore, the activation of both of these signaling pathways can regulate the activity of downstream

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0039
Volume/Issue:
Volume 233: Issue 2
Free access
N Zlocowski Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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L d V Sosa Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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B De la Cruz-Thea Cellular and Molecular Neurobiology Department, CONICET - Universidad Nacional de Córdoba - Instituto de Investigación Médica Mercedes y Martín Ferreyra, Córdoba, Argentina

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C B Guido Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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M G Martín Cellular and Molecular Neurobiology Department, CONICET - Universidad Nacional de Córdoba - Instituto de Investigación Médica Mercedes y Martín Ferreyra, Córdoba, Argentina

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J H Mukdsi Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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A I Torres Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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J P Petiti Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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regulation of the growth factors and signaling pathways that modulate the cell cycle, as well as genetic defects and epigenetic deregulation ( Asa & Ezzat 2002 , Ezzat et al. 2018 , Chang et al. 2020 , Sabatino et al. 2022 ). However, no single

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0195
Volume/Issue:
Volume 257: Issue 2
Restricted access
Parsanathan Rajesh Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India

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Karundevi Balasubramanian Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India

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exposures, and that these ‘programmable’ diseases are associated with epigenetic modifications of vital genes ( Strakovsky & Pan 2012 ). While little is currently known about the epigenetic changes induced by the endocrine disruptors, especially DEHP

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0111
Volume/Issue:
Volume 223: Issue 1
Free access