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Milan Obradovic
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Predrag Bjelogrlic Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Manfredi Rizzo Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia
Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Niki Katsiki Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Mohamed Haidara Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia
Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Alan J Stewart Laboratory of Radiobiology and Molecular Genetics, School of Medicine, Department of Internal Medicine and Medical Specialties, Euro-Mediterranean Institute of Science and Technology, Second Propedeutic Department of Internal Medicine, Department of Physiology, Department of Physiology, Institute Vinca, University of Belgrade, PO Box 522, 11000 Belgrade, Serbia

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Aleksandra Jovanovic
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Esma R Isenovic
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protein concentration contributes to the deficiencies in cardiac contractility in animal models and has been documented in patients with heart failure (HF; Schwinger et al . 2003 , Liu et al . 2012 ). The majority of hormones (e.g. insulin, estradiol

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Carmen Corciulo Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Julia M Scheffler Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Piotr Humeniuk Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Alicia Del Carpio Pons Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Alexandra Stubelius Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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Ula Von Mentzer Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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Christina Drevinge Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Aidan Barrett Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Sofia Wüstenhagen Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Matti Poutanen Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland

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Claes Ohlsson Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden

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Marie K Lagerquist Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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Ulrika Islander Centre for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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. 2021 ). Moreover, estradiol is a well-known regulator of bone and immune system homeostasis and also controls motor ability and pain sensitivity ( Straub 2007 ). Although epidemiological studies reported that postmenopausal women have a higher risk to

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Ismael González-García Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Pablo B Martínez de Morentin Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Ánxela Estévez-Salguero Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Cristina Contreras Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Amparo Romero-Picó Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Johan Fernø Hormone Laboratory, Haukeland University Hospital, Bergen, Norway
KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway

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Rubén Nogueiras Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Carlos Diéguez Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Manuel Tena-Sempere Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain
Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Reina Sofía, Córdoba, Spain
FiDiPro Program, University of Turku, Turku, Finland

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Sulay Tovar Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Miguel López Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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showed that reduced levels of estradiol (E2) after ovariectomy (OVX) are associated with hyperphagia and decreased energy expenditure, leading to weight gain ( Martínez de Morentin et al. 2014 a , 2015 ). Moreover, variations in the magnitude of

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Li Zhang State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, People’s Republic of China

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XiaoXin Zhang State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, China University of Chinese Academy of Sciences, Beijing, People’s Republic of China

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Xuejing Zhang State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, People’s Republic of China

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Yu Lu State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, People’s Republic of China

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Lei Li State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, China University of Chinese Academy of Sciences, Beijing, People’s Republic of China

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Sheng Cui State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, People’s Republic of China

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( Craig et al. 2007 ), and the estradiol synthesized from the granulosa cells is required for the structure and function of female reproductive tissues. Many extra- and intra-ovarian factors have been implicated in granulosa cell proliferation and

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Adam C Guzzo Department of Psychology, Neuroscience and Behaviour, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1

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Tyler Pollock Department of Psychology, Neuroscience and Behaviour, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1

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Denys deCatanzaro Department of Psychology, Neuroscience and Behaviour, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1

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, deCatanzaro et al . 2006 , Khan et al . 2009 , Thorpe & deCatanzaro 2012 ). Indeed, recent data suggest that small lipophilic steroids such as estradiol-17β (E 2 ) could transfer directly between cohabiting individuals ( Guzzo et al . 2010 , 2012 ). The

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Hiroto Kobayashi Department of Anatomy and Structural Science, Yamagata University Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan

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Saori Yoshida Department of Anatomy and Structural Science, Yamagata University Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan

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Ying-Jie Sun Department of Anatomy and Structural Science, Yamagata University Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan

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Nobuyuki Shirasawa Department of Anatomy and Structural Science, Yamagata University Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan

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Akira Naito Department of Anatomy and Structural Science, Yamagata University Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan

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is equivalent to that in the ovary, and the estradiol-17β (E 2 ) levels in the portal vein were much higher than those found in arterial blood. Then it was suggested that about 90% of gastric E 2 is bound to estrogen receptors (ER) in the liver. Our

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Caroline Alfaia PRC, INRA, CNRS, IFCE, Tours University, Nouzilly, France

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Vincent Robert PRC, INRA, CNRS, IFCE, Tours University, Nouzilly, France

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Kevin Poissenot PRC, INRA, CNRS, IFCE, Tours University, Nouzilly, France

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Yves Levern ISP, INRA, Tours University, Nouzilly, France

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Daniel Guillaume PRC, INRA, CNRS, IFCE, Tours University, Nouzilly, France

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Shel-Hwa Yeo Reproductive Physiology Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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William H Colledge Reproductive Physiology Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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Isabelle Franceschini PRC, INRA, CNRS, IFCE, Tours University, Nouzilly, France

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population at E16.5. The discovery of higher levels of Esr1 in the ARC Kiss1 cells of female fetuses prompted us to compare the direct estradiol responsiveness of ARC Kiss1 cells in vitro specifically sorted from male and female fetuses

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Sandra Vallcaneras Laboratorio de Biología de la Reproducción (LABIR), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL-CONICET), San Luis, Argentina

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Federica Ghersa Laboratorio de Biología de la Reproducción (LABIR), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL-CONICET), San Luis, Argentina

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Juan Bastón Laboratorio de Fisiopatología Endometrial, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina

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María Belén Delsouc Laboratorio de Biología de la Reproducción (LABIR), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL-CONICET), San Luis, Argentina

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Gabriela Meresman Laboratorio de Fisiopatología Endometrial, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina

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Marilina Casais Laboratorio de Biología de la Reproducción (LABIR), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL-CONICET), San Luis, Argentina

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( Bruner et al. 1997 , Pitsos & Kanakas 2009 ). In relation to this, there exists a correlation between the levels of MMP-2 and estradiol in the peritoneal fluid of patients with endometriosis ( Huang et al . 2004 ). In turn, steroid hormones play an

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Romain Fontaine Department of Preclinical Sciences and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway

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Eirill Ager-Wick Department of Preclinical Sciences and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway

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Kjetil Hodne Department of Preclinical Sciences and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway

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Finn-Arne Weltzien Department of Preclinical Sciences and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway

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incubation To study effects of sexual steroids on Fsh and Lh cell proliferation, three groups of tg( lhb -hrGfpII) adult fish (six females and six males) were incubated for 6 days in daily renewed system water containing 100 μg/L of either 17β-estradiol

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M Victoria Recouvreux Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina

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M Andrea Camilletti Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina

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Daniel B Rifkin Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina

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Graciela Díaz-Torga Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina

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SSTR in human prolactinomas ( Jaquet et al. 1999 ). Based on the counteracting effects of estradiol on dopamine action in lactotrophs, targeting of the estrogen receptor with tamoxifen was evaluated in the pre-cabergoline era in patients with

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