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Koen D Flach Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Wilbert Zwart Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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this disease every year ( Ferlay et al. 2015 ). Approximately 70% of breast tumors are estrogen receptor α (ERα) positive, and tumor cell proliferation is thought to be dependent on the activity of this hormone-mediated transcription factor ( Hayashi

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0003
Volume/Issue:
Volume 229: Issue 2
Free access
Lin-Yu Jin Department of spinal surgery, Peking University People’s Hospital, Peking University, Beijing, China
Department of spinal surgery, enji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

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Zhen-Dong Lv Department of spinal surgery, enji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

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Xin-Jin Su Department of spinal surgery, enji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

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Shuai Xu Department of spinal surgery, Peking University People’s Hospital, Peking University, Beijing, China

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Hai-Ying Liu Department of spinal surgery, Peking University People’s Hospital, Peking University, Beijing, China

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Xin-Feng Li Department of spinal surgery, enji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

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sex steroid in female mammals and it plays an important role in regulating the longitudinal bone growth via estrogen receptors (ERα and ERβ) ( Börjesson et al. 2013 ). ERs (α and β) have been reported to be expressed in the GP in humans and rodents

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0049
Volume/Issue:
Volume 250: Issue 1
Restricted access
Kushaan Dumasia Department of Neuroendocrinology, National Institute for Research in Reproductive Health (Indian Council of Medical Research), Parel, Mumbai 400 012, India

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Anita Kumar Department of Neuroendocrinology, National Institute for Research in Reproductive Health (Indian Council of Medical Research), Parel, Mumbai 400 012, India

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Leena Kadam Department of Neuroendocrinology, National Institute for Research in Reproductive Health (Indian Council of Medical Research), Parel, Mumbai 400 012, India

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N H Balasinor Department of Neuroendocrinology, National Institute for Research in Reproductive Health (Indian Council of Medical Research), Parel, Mumbai 400 012, India

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( Carreau et al . 1999 ). The cellular effects of E 2 are mediated through its receptors; estrogen receptor α (ERα) and β (ERβ) which belong to the steroid hormone superfamily of nuclear receptors and upon binding to their ligands act as transcription

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0045
Volume/Issue:
Volume 225: Issue 3
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Isabelle Lee Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Philadelphia, Philadelphia, Pennsylvania, USA

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Guannan Zhang Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Philadelphia, Philadelphia, Pennsylvania, USA
Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Philadelphia, Philadelphia, Pennsylvania, USA

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Clementina Mesaros Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Philadelphia, Philadelphia, Pennsylvania, USA
Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Philadelphia, Philadelphia, Pennsylvania, USA

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Trevor M Penning Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Philadelphia, Philadelphia, Pennsylvania, USA
Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Philadelphia, Philadelphia, Pennsylvania, USA

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the growing list of endocrine-disrupting chemicals. PAHs have been implicated in estrogen receptor-dependent cancers. Women had a twofold increased risk of breast cancer associated with detectable levels of PAH relative to women with non

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0579
Volume/Issue:
Volume 247: Issue 2
Free access
M Merle Elloso Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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Kristen Phiel Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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Ruth A Henderson Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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Heather A Harris Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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Steven J Adelman Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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that estrogen has biphasic effects on cytokine secretion ( Gilmore et al. 1997 ). These results suggest that estrogens could potentially alter disease through direct binding to estrogen receptors (ERs) on pathogenic T cells. Estrogen action is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06063
Volume/Issue:
Volume 185: Issue 2
Free access
Ekaterine Tskitishvili Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Christel Pequeux Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Carine Munaut Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Renaud Viellevoye Department of Pediatrics, Neonatal Intensive Care Unit, University of Liege, CHR de la CITADELLE, Liege, Belgium

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Michelle Nisolle Department of Obstetrics and Gynecology, University of Liege, CHR de la CITADELLE, Liege, Belgium

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Agnes Noël Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Jean-Michel Foidart Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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( Shankaran et al . 2005 ). So far, no medical treatment provides important neuroprotection against neonatal HIE. E4 is a natural human fetal estrogen with selective estrogen receptor modulator activity (SERM) ( Abot et al . 2014 ). Its synthesis amounts

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0434
Volume/Issue:
Volume 232: Issue 1
Open access
Seiji Tsutsumi
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Xi Zhang
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Keiko Takata
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Kazuhiro Takahashi
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Richard H Karas Department of Obstetrics and Gynecology, Molecular Cardiology Research Institute, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan

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Hirohisa Kurachi
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Michael E Mendelsohn Department of Obstetrics and Gynecology, Molecular Cardiology Research Institute, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan

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Introduction Physiological effects of estrogen on vascular smooth muscle cells (VSMC) are mediated by two intracellular estrogen receptors (ESR1 and 2), which regulate transcription of target genes following ligand activation through binding to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0292
Volume/Issue:
Volume 199: Issue 2
Free access
Ali Aflatounian Fertility and Research Centre, School of Women’s & Children’s Health, University of New South Wales Sydney, New South Wales, Australia

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Melissa C Edwards Fertility and Research Centre, School of Women’s & Children’s Health, University of New South Wales Sydney, New South Wales, Australia
Andrology Laboratory, ANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, New South Wales, Australia

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Valentina Rodriguez Paris Fertility and Research Centre, School of Women’s & Children’s Health, University of New South Wales Sydney, New South Wales, Australia

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Michael J Bertoldo Fertility and Research Centre, School of Women’s & Children’s Health, University of New South Wales Sydney, New South Wales, Australia
Laboratory for Ageing Research, School of Medical Sciences, University of New South Wales Sydney, New South Wales, Australia

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Reena Desai Andrology Laboratory, ANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, New South Wales, Australia

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Robert B Gilchrist Fertility and Research Centre, School of Women’s & Children’s Health, University of New South Wales Sydney, New South Wales, Australia

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William L Ledger Fertility and Research Centre, School of Women’s & Children’s Health, University of New South Wales Sydney, New South Wales, Australia

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David J Handelsman Andrology Laboratory, ANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, New South Wales, Australia

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Kirsty A Walters Fertility and Research Centre, School of Women’s & Children’s Health, University of New South Wales Sydney, New South Wales, Australia
Andrology Laboratory, ANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, New South Wales, Australia

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& Auchus 2007 ), and act via the estrogen receptor (ER). Notably, testosterone, which is readily aromatized into estradiol, is a major circulating androgen in women and is elevated in the majority of women with PCOS ( Davison & Davis 2003 , Handelsman et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0530
Volume/Issue:
Volume 245: Issue 3
Restricted access
Marcello Maggiolini
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Didier Picard Department of Pharmaco-Biology, Département de Biologie Cellulaire, University of Calabria, 87030 Rende, Italy

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β-estradiol (E 2 ), is no exception. Estrogens have a multitude of different molecular targets, including two well-characterized members of the nuclear receptor superfamily, the estrogen receptors (ER) α and β (listed as ESR1 and ESR2 in the HUGO

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0242
Volume/Issue:
Volume 204: Issue 2
Free access
Melyssa R Bratton Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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James W Antoon Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Bich N Duong Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Daniel E Frigo Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Syreeta Tilghman Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Bridgette M Collins-Burow Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Steven Elliott Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Yan Tang Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Lilia I Melnik Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Ling Lai Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Jawed Alam Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Barbara S Beckman Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Steven M Hill Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Brian G Rowan Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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John A McLachlan Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Matthew E Burow Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of

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Introduction Various agents regulate estrogen receptor α (ERα) activity in addition to 17β-estradiol (E 2 ), including peptide growth factors (PGFs) such as epidermal growth factor (EGF) and insulin-like growth factor 1 (IGF1; Ignar-Trowbridge et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0097
Volume/Issue:
Volume 214: Issue 1
Free access