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H H Farman
H H Farman
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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K L Gustafsson
K L Gustafsson
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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P Henning
P Henning
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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L Grahnemo
L Grahnemo
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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V Lionikaite
V Lionikaite
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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S Movérare-Skrtic
S Movérare-Skrtic
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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J Wu
J Wu
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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H Ryberg
H Ryberg
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
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Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
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A Koskela
A Koskela
Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland
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J Tuukkanen
J Tuukkanen
Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland
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E R Levin
E R Levin
Division of Endocrinology, Departments of Medicine and Biochemistry, University of California, Irvine, California, USA
The Long Beach VA Medical Center, Long Beach, California, USA
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The Long Beach VA Medical Center, Long Beach, California, USA
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C Ohlsson
C Ohlsson
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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M K Lagerquist
M K Lagerquist
Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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The importance of estrogen receptor α (ERα) for the regulation of bone mass in males is well established. ERα mediates estrogenic effects both via nuclear and membrane-initiated ERα (mERα) signaling. The role of mERα signaling for the effects of estrogen on bone in male mice is unknown. To investigate the role of mERα signaling, we have used mice (Nuclear-Only-ER; NOER) with a point mutation (C451A), which results in inhibited trafficking of ERα to the plasma membrane. Gonadal-intact male NOER mice had a significantly decreased total body areal bone mineral density (aBMD) compared to WT littermates at 3, 6 and 9 months of age as measured by dual-energy X-ray absorptiometry (DEXA). High-resolution microcomputed tomography (µCT) analysis of tibia in 3-month-old males demonstrated a decrease in cortical and trabecular thickness in NOER mice compared to WT littermates. As expected, estradiol (E2) treatment of orchidectomized (ORX) WT mice increased total body aBMD, trabecular BV/TV and cortical thickness in tibia compared to placebo treatment. E2 treatment increased these skeletal parameters also in ORX NOER mice. However, the estrogenic responses were significantly decreased in ORX NOER mice compared with ORX WT mice. In conclusion, mERα is essential for normal estrogen signaling in both trabecular and cortical bone in male mice. Increased knowledge of estrogen signaling mechanisms in the regulation of the male skeleton may aid in the development of new treatment options for male osteoporosis.
Melyssa R Bratton
Melyssa R Bratton
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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James W Antoon
James W Antoon
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Bich N Duong
Bich N Duong
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Daniel E Frigo
Daniel E Frigo
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Syreeta Tilghman
Syreeta Tilghman
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Bridgette M Collins-Burow
Bridgette M Collins-Burow
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Steven Elliott
Steven Elliott
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Yan Tang
Yan Tang
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Lilia I Melnik
Lilia I Melnik
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Ling Lai
Ling Lai
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Jawed Alam
Jawed Alam
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Barbara S Beckman
Barbara S Beckman
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Steven M Hill
Steven M Hill
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Brian G Rowan
Brian G Rowan
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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John A McLachlan
John A McLachlan
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Matthew E Burow
Matthew E Burow
Section of Hematology and Medical Oncology, Structural and Cellular Biology, Department of Medical Genetics, Center for Nuclear Receptors and Cell Signaling, Department of Medicine, Tulane University, 1430 Tulane Avenue, SL-78, New Orleans, Louisiana 70112, USA Departments of
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Introduction Various agents regulate estrogen receptor α (ERα) activity in addition to 17β-estradiol (E 2 ), including peptide growth factors (PGFs) such as epidermal growth factor (EGF) and insulin-like growth factor 1 (IGF1; Ignar-Trowbridge et
Beverly A S Reyes
Beverly A S Reyes
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Hiroko Tsukamura
Hiroko Tsukamura
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Helen I’Anson
Helen I’Anson
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Maria Amelita C Estacio
Maria Amelita C Estacio
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Kanjun Hirunagi
Kanjun Hirunagi
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Kei-Ichiro Maeda
Kei-Ichiro Maeda
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Department of Biology, Washington and Lee University, Lexington, Virginia 24450-03, USA
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suppression of LH secretion. Table 1 Number of estrogen receptor α (ERα), dopamine-β-hydroxylase (DBH), and dual-labeled cells in the nucleus of the solitary tract of 48-h fasted and unfasted ovariectomized rats ( n =4) ER α DBH ER α+ DBH Double
Liyuan Tian
Liyuan Tian
Molecular Biology, Endocrinology, Departments of
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Zhiqiang Wu
Zhiqiang Wu
Molecular Biology, Endocrinology, Departments of
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Yali Zhao
Yali Zhao
Molecular Biology, Endocrinology, Departments of
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Yuanguang Meng
Yuanguang Meng
Molecular Biology, Endocrinology, Departments of
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Yiling Si
Yiling Si
Molecular Biology, Endocrinology, Departments of
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Xiaobing Fu
Xiaobing Fu
Molecular Biology, Endocrinology, Departments of
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Yiming Mu
Yiming Mu
Molecular Biology, Endocrinology, Departments of
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Weidong Han
Weidong Han
Molecular Biology, Endocrinology, Departments of
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XJ Yu L Song HJ Li M Lu JM Zhao YL 2003 Up-regulation of LRP16 mRNA by 17β-estradiol through activation of estrogen receptor α (ERα), but not estrogen receptor β (ERβ), and promotes human breast cancer MCF-7 cell proliferation: a
L Lundholm
L Lundholm
Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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G Bryzgalova
G Bryzgalova
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H Gao
H Gao
Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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N Portwood
N Portwood
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S Fält
S Fält
Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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K D Berndt
K D Berndt
Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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A Dicker
A Dicker
Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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D Galuska
D Galuska
Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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J R Zierath
J R Zierath
Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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J-Å Gustafsson
J-Å Gustafsson
Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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S Efendic
S Efendic
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K Dahlman-Wright
K Dahlman-Wright
Department of Molecular Medicine and Surgery, Department of Biosciences and Nutrition, Department of Medicine, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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A Khan
A Khan
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Medicine 13 89 – 94 . Gao H Falt S Sandelin A Gustafsson JA Dahlman-Wright K 2008 Genome-wide identification of estrogen receptor α-binding sites in mouse liver . Molecular Endocrinology 22 10 – 22 . Geisler JG Zawalich W Zawalich
Jonathan Lindzey
Jonathan Lindzey
Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3-02, PO Box 12233, Research Triangle Park, North Carolina 27709, USA
Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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Friederike L Jayes
Friederike L Jayes
Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3-02, PO Box 12233, Research Triangle Park, North Carolina 27709, USA
Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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Mariana M Yates
Mariana M Yates
Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3-02, PO Box 12233, Research Triangle Park, North Carolina 27709, USA
Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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John F Couse
John F Couse
Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3-02, PO Box 12233, Research Triangle Park, North Carolina 27709, USA
Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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Kenneth S Korach
Kenneth S Korach
Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3-02, PO Box 12233, Research Triangle Park, North Carolina 27709, USA
Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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Department of Biological Sciences, Lock Haven University, Lock Haven, Pennsylvania 17745, USA
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distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) messenger ribonucleic acid in the wild-type and ERα-knockout mouse. Endocrinology 138 4613 –4621. Couse JF , Bunch DO, Lindzey J
J Varayoud
J Varayoud
Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina
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J G Ramos
J G Ramos
Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina
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L Monje
L Monje
Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina
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V Bosquiazzo
V Bosquiazzo
Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina
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M Muñoz-de-Toro
M Muñoz-de-Toro
Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina
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E H Luque
E H Luque
Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, Santa Fe, Argentina
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-Buck V & Gannon F 1998 Differentially expressed messenger RNA isoforms of the human estrogen receptor-α gene are generated by alternative splicing and promoter usage. Molecular Endocrinology 12 1939 –1954. Friend KE
C D Simmons
C D Simmons
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J M P Pabona
J M P Pabona
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Z Zeng
Z Zeng
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M C Velarde
M C Velarde
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D Gaddy
D Gaddy
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F A Simmen
F A Simmen
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R C M Simmen
R C M Simmen
Department of Physiology and Biophysics, Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, Arkansas 72202, USA
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Introduction The steroid hormone 17β-estradiol (E 2 ) regulates numerous physiological and developmental processes in target tissues by binding to its cognate receptors estrogen receptor-α (ESR1) and -β (ESR2) in the presence of numerous co
Mirja Rotinen
Mirja Rotinen
Department of Health Sciences, Universidad Pública de Navarra, Avda. Barañain, 31008 Pamplona, Spain
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Jon Celay
Jon Celay
Department of Health Sciences, Universidad Pública de Navarra, Avda. Barañain, 31008 Pamplona, Spain
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Marta M Alonso
Marta M Alonso
Department of Health Sciences, Universidad Pública de Navarra, Avda. Barañain, 31008 Pamplona, Spain
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Aranzazu Arrazola
Aranzazu Arrazola
Department of Health Sciences, Universidad Pública de Navarra, Avda. Barañain, 31008 Pamplona, Spain
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Ignacio Encio
Ignacio Encio
Department of Health Sciences, Universidad Pública de Navarra, Avda. Barañain, 31008 Pamplona, Spain
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Joaquin Villar
Joaquin Villar
Department of Health Sciences, Universidad Pública de Navarra, Avda. Barañain, 31008 Pamplona, Spain
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et al . 2003 , Khalyfa et al . 2003 , Bourdeau et al . 2004 ). Estrogens modulate transcription in their target tissues through estrogen receptor α (ERα) or ERβ receptors using a number of signaling pathways. The ‘classical’ pathway involves
Rhone A Mendoza
Rhone A Mendoza
Department of Biomedical Sciences, Center of Excellence in Cancer Research, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine, 5001 El Paso Drive, El Paso, Texas 79905, USA
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Marlene I Enriquez
Marlene I Enriquez
Department of Biomedical Sciences, Center of Excellence in Cancer Research, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine, 5001 El Paso Drive, El Paso, Texas 79905, USA
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Sylvia M Mejia
Sylvia M Mejia
Department of Biomedical Sciences, Center of Excellence in Cancer Research, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine, 5001 El Paso Drive, El Paso, Texas 79905, USA
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Emily E Moody
Emily E Moody
Department of Biomedical Sciences, Center of Excellence in Cancer Research, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine, 5001 El Paso Drive, El Paso, Texas 79905, USA
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Gudmundur Thordarson
Gudmundur Thordarson
Department of Biomedical Sciences, Center of Excellence in Cancer Research, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine, 5001 El Paso Drive, El Paso, Texas 79905, USA
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blot analysis showing expression of the estrogen receptor-α (ERα), the progesterone receptor (PR), and the ERβ in cloned MCF-7 cells stably transfected with a vector producing a small interfering RNA (siRNA) to the insulin-like growth factor-I receptor
