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Sabina Paglialunga Department of Biochemistry, McGill University, Montreal, Canada H3G 1V6
Centre de Recherche de l’Hôpital Laval, Université Laval, Y2186, 2725 Chemin Ste-Foy, Québec, Canada G1V 4G5
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht,
Movement Sciences, Maastricht University, Maastricht, 6200 The Netherlands

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Patrick Schrauwen Department of Biochemistry, McGill University, Montreal, Canada H3G 1V6
Centre de Recherche de l’Hôpital Laval, Université Laval, Y2186, 2725 Chemin Ste-Foy, Québec, Canada G1V 4G5
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht,
Movement Sciences, Maastricht University, Maastricht, 6200 The Netherlands

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Christian Roy Department of Biochemistry, McGill University, Montreal, Canada H3G 1V6
Centre de Recherche de l’Hôpital Laval, Université Laval, Y2186, 2725 Chemin Ste-Foy, Québec, Canada G1V 4G5
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht,
Movement Sciences, Maastricht University, Maastricht, 6200 The Netherlands

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Esther Moonen-Kornips Department of Biochemistry, McGill University, Montreal, Canada H3G 1V6
Centre de Recherche de l’Hôpital Laval, Université Laval, Y2186, 2725 Chemin Ste-Foy, Québec, Canada G1V 4G5
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht,
Movement Sciences, Maastricht University, Maastricht, 6200 The Netherlands

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Huiling Lu Department of Biochemistry, McGill University, Montreal, Canada H3G 1V6
Centre de Recherche de l’Hôpital Laval, Université Laval, Y2186, 2725 Chemin Ste-Foy, Québec, Canada G1V 4G5
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht,
Movement Sciences, Maastricht University, Maastricht, 6200 The Netherlands

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Matthijs K C Hesselink Department of Biochemistry, McGill University, Montreal, Canada H3G 1V6
Centre de Recherche de l’Hôpital Laval, Université Laval, Y2186, 2725 Chemin Ste-Foy, Québec, Canada G1V 4G5
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht,
Movement Sciences, Maastricht University, Maastricht, 6200 The Netherlands

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Yves Deshaies Department of Biochemistry, McGill University, Montreal, Canada H3G 1V6
Centre de Recherche de l’Hôpital Laval, Université Laval, Y2186, 2725 Chemin Ste-Foy, Québec, Canada G1V 4G5
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht,
Movement Sciences, Maastricht University, Maastricht, 6200 The Netherlands

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Denis Richard Department of Biochemistry, McGill University, Montreal, Canada H3G 1V6
Centre de Recherche de l’Hôpital Laval, Université Laval, Y2186, 2725 Chemin Ste-Foy, Québec, Canada G1V 4G5
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht,
Movement Sciences, Maastricht University, Maastricht, 6200 The Netherlands

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Katherine Cianflone Department of Biochemistry, McGill University, Montreal, Canada H3G 1V6
Centre de Recherche de l’Hôpital Laval, Université Laval, Y2186, 2725 Chemin Ste-Foy, Québec, Canada G1V 4G5
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht,
Movement Sciences, Maastricht University, Maastricht, 6200 The Netherlands

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) with no change in skeletal muscle GLUT-4 protein levels as assessed by western analysis (data not shown). Evaluation of fatty acid oxidation The increased food intake despite similar weight gain in C5L2KO-LF mice

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0205
Volume/Issue:
Volume 194: Issue 2
Free access
Sihan Lv Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Xinchen Qiu Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Jian Li Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Jinye Liang Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Weida Li Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Chao Zhang Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Zhen-Ning Zhang Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

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Bing Luan Department of Endocrinology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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& Karin 2012 ). Disrupted lipid metabolism including fatty acid oxidation and de novo lipogenesis in liver results in the development of hepatic steatosis and contributes to the development of hepatic insulin resistance ( Marchesini et al . 2003

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0649
Volume/Issue:
Volume 234: Issue 2
Free access
Melanie Tran Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Golam Mostofa Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Michael Picard Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Jianguo Wu Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Li Wang Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA

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Dong-Ju Shin Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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timepoints 0, 5, 10, 15, 30, and 60 min after the 6 h fasting period, then cell lysates were collected for immunoblotting analyses. Biochemical analysis Fatty acid oxidation (FAO) enzyme activity was measured in livers of HFHS-fed mice using a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0073
Volume/Issue:
Volume 256: Issue 3
Restricted access
MC Sugden
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HS Lall
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RA Harris
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MJ Holness
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The pyruvate dehydrogenase kinases (PDK1-4) regulate glucose oxidation through inhibitory phosphorylation of the pyruvate dehydrogenase complex (PDC). Immunoblot analysis with antibodies raised against recombinant PDK isoforms demonstrated changes in PDK isoform expression in response to experimental hyperthyroidism (100 microg/100 g body weight; 3 days) that was selective for fast-twitch vs slow-twitch skeletal muscle in that PDK2 expression was increased in the fast-twitch skeletal muscle (the anterior tibialis) (by 1. 6-fold; P<0.05) but not in the slow-twitch muscle (the soleus). PDK4 protein expression was increased by experimental hyperthyroidism in both muscle types, there being a greater response in the anterior tibialis (4.2-fold increase; P<0.05) than in the soleus (3.2-fold increase; P<0.05). The hyperthyroidism-associated up-regulation of PDK4 expression was observed in conjunction with suppression of skeletal-muscle PDC activity, but not suppression of glucose uptake/phosphorylation, as measured in vivo in conscious unrestrained rats (using the 2-[(3)H]deoxyglucose technique). We propose that increased PDK isoform expression contributes to the pathology of hyperthyroidism and to PDC inactivation by facilitating the operation of the glucose --> lactate --> glucose (Cori) and glucose --> alanine --> glucose cycles. We also propose that enhanced relative expression of the pyruvate-insensitive PDK isoform (PDK4) in skeletal muscle in hyperthyroidism uncouples glycolytic flux from pyruvate oxidation, sparing pyruvate for non-oxidative entry into the tricarboxylic acid (TCA) cycle, and thereby supporting entry of acetyl-CoA (derived from fatty acid oxidation) into the TCA cycle.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1670339
Volume/Issue:
Volume 167: Issue 2
Free access
Eun Hee Koh Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Ah-Ram Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hyunshik Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jin Hee Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hye-Sun Park Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Myoung Seok Ko Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Mi-Ok Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hyuk-Joong Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Bum Joong Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hyun Ju Yoo Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Su Jung Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jin Sun Oh Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Chang-Yun Woo Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jung Eun Jang Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jaechan Leem Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Myung Hwan Cho Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Ki-Up Lee Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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, proton leakage, maximal OCR, reserve capacity and non-mitochondrial OCR) were analyzed as described by Hill et al . (2012) ( Supplementary Figure 2 , see section on supplementary data given at the end of this article). Fatty acid oxidation The fatty

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0117
Volume/Issue:
Volume 225: Issue 3
Free access
Prasanthi P Koganti Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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Vimal Selvaraj Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA

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status between the mouse and hamster adrenals, we evaluated the expression of a few core genes involved in the regulation of these processes. We found that Cpt1a , a transferase essential for mitochondrial fatty acid oxidation (FAO), was substantially

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0189
Volume/Issue:
Volume 247: Issue 1
Restricted access
Sung-Soo Park Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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Yeon-Joo Lee Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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Sooyeon Song Division of Animal Science, College of Agriculture & Life Science, Chonnam National University, Gwangju, South Korea

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Boyong Kim Gwangju Center, Korea Basic Science Institute, Gwangju, South Korea

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Hyuno Kang Gwangju Center, Korea Basic Science Institute, Gwangju, South Korea

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Sejong Oh Division of Animal Science, College of Agriculture & Life Science, Chonnam National University, Gwangju, South Korea

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Eungseok Kim Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju, South Korea

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unexplored. The liver plays a key role in whole-body energy homeostasis by regulating lipogenesis and fatty acid oxidation ( Reddy & Rao 2006 ). A large body of evidence has shown that two transcription factors, sterol regulatory element-binding protein 1c

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0592
Volume/Issue:
Volume 237: Issue 2
Free access
Giselle Adriana Abruzzese Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Maria Florencia Heber Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Silvana Rocio Ferreira Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Leandro Martin Velez Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Roxana Reynoso Laboratorio de Endocrinología, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Omar Pedro Pignataro Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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Alicia Beatriz Motta Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

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. Regarding fatty acid oxidation pathways, we found that Pparα mRNA levels showed no differences between the control and PHov groups but were decreased in PHanov ( Fig. 3H , P <0.01), and that Pgc1α levels were lower in both PH animals than in controls

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0471
Volume/Issue:
Volume 230: Issue 1
Free access
Andrea Anedda Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain

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Eduardo Rial Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain

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M Mar González-Barroso Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain

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present study was to determine whether UCP2 is involved in the action of metformin on white adipocytes. The working hypothesis was that UCP2 could be overexpressed either to uncouple respiration to facilitate fatty acid oxidation or to minimize the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0278
Volume/Issue:
Volume 199: Issue 1
Free access
Jonathan M Mudry Section for Integrative Physiology, Section for Integrative Physiology, Department of Molecular Medicine and Surgery

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Julie Massart Section for Integrative Physiology, Section for Integrative Physiology, Department of Molecular Medicine and Surgery

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Ferenc L M Szekeres Section for Integrative Physiology, Section for Integrative Physiology, Department of Molecular Medicine and Surgery

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Anna Krook Section for Integrative Physiology, Section for Integrative Physiology, Department of Molecular Medicine and Surgery
Section for Integrative Physiology, Section for Integrative Physiology, Department of Molecular Medicine and Surgery

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of the phosphorylated form of ACC was unchanged, leading to a larger ratio of inactivated ACC. In cultured C2C12 cells overexpressing TWIST1 or TWIST2, fatty acid oxidation in vitro was unchanged. Thus if glucose utilization is increased while fatty

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0474
Volume/Issue:
Volume 224: Issue 3
Free access