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Rachel V Richardson, Emma J Batchen, Adrian J W Thomson, Rowan Darroch, Xinlu Pan, Eva A Rog-Zielinska, Wiktoria Wyrzykowska, Kathleen Scullion, Emad A S Al-Dujaili, Mary E Diaz, Carmel M Moran, Christopher J Kenyon, Gillian A Gray and Karen E Chapman

is pro-inflammatory in the heart and associates with cardiac fibrosis, inflammation and heart failure ( Messaoudi et al . 2012 , Young & Rickard 2015 ). The effectiveness of MR antagonism in the treatment of heart failure has focussed its attention

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Wu Luo, Lan Huang, Jingying Wang, Fei Zhuang, Zheng Xu, Haimin Yin, Yuanyuan Qian, Guang Liang, Chao Zheng and Yi Wang

interstitial and perivascular fibrosis, ventricular hypertrophy, as well as diastolic and systolic dysfunction, all occurring in the absence of coronary artery disease and hypertension ( Bugger & Abel 2014 ). The underlying factors driving the development of

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Andrew W Norris, Katie Larson Ode, Lina Merjaneh, Srinath Sanda, Yaling Yi, Xingshen Sun, John F Engelhardt and Rebecca L Hull

Overview Cystic fibrosis (CF) is the most common markedly life-shortening autosomal recessive genetic condition in people of Northern European descent, affecting approximately 0.05% of live births. It is caused by loss-of-function mutations in

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Jie Wei, Xia Sun, Yajie Chen, Yuanyuan Li, Liqiong Song, Zhao Zhou, Bing Xu, Yi Lin and Shunqing Xu

population in Western countries and 9–40% of people in Asian countries ( Farrell & Larter 2006 ). A subset of patients with NAFLD may progress to nonalcoholic steatohepatitis (NASH), a more severe form of hepatic damage associated with inflammation, fibrosis

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Weixia Han, Chen Wang, Zhifen Yang, Lin Mu, Ming Wu, Nan Chen, Chunyang Du, Huijun Duan and Yonghong Shi

Introduction Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus, accounting for almost 50% of all end-stage renal disease cases. Renal fibrosis is a major characteristic of DN and an important predictor of renal

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A Edlund, M Barghouth, M Hühn, M Abels, J S E Esguerra, I G Mollet, E Svedin, A Wendt, E Renström, E Zhang, N Wierup, B J Scholte, M Flodström-Tullberg and L Eliasson

Introduction Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in CFTR encoding the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is an anion channel that conducts Cl − and HCO 3 − and is

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Gordon J Allan, James Beattie and David J Flint

Overview of the fibrotic response Excessive fibroblast activation can result in debilitating and even fatal diseases which progress rapidly from diagnosis. These include idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc), the latter

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Shuang-Xia Zhao, Shanli Tsui, Anthony Cheung, Raymond S Douglas, Terry J Smith and J Paul Banga

plasmids encoding human TSHR A-subunit combined with electroporation results in hyperthyroidism, generation of TSAbs, appearance of antibodies to IGF1R, microscopic thyroid infiltrates, and moderate orbital fibrosis. Recently, Eckstein and colleagues have

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H J Novaira, D S Ornellas, T M Ortiga-Carvalho, X M Zhang, J Souza-Menezes, S E Guggino, W B Guggino and M M Morales

Introduction The cystic fibrosis transmembrane conductance regulator (CFTR) is the most intensively investigated Cl − channel and it was the first anion channel to be identified by expression cloning ( Riordan et al. 1989

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Steffen Søndergaard Madsen, Lars Nørholm Jensen, Christian Kølbæk Tipsmark, Pia Kiilerich and Russell John Borski

Marshall 2002 ). The molecular nature of the latter is largely unknown, but has recently been associated with the presence of cystic fibrosis transmembrane conductance regulator-like (CFTR) immunoreactivity in killifish ( Fundulus heteroclitus ) chloride