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Dieuwertje C E Spaanderman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Mark Nixon BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Jacobus C Buurstede Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Hetty H C M Sips Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Maaike Schilperoort Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Eline N Kuipers Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Emma A Backer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Natalie Z M Homer BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Brian R Walker BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Institute for Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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Onno C Meijer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Jan Kroon Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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). Glucocorticoid action in metabolism is predominantly mediated by glucocorticoid receptors (GRs) which are expressed in virtually all tissues in both humans and rodents. It is known that glucocorticoid transcriptional activity is subject to multiple levels of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0503
Volume/Issue:
Volume 240: Issue 1
Free access
Rachel V Richardson University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emma J Batchen University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Adrian J W Thomson Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Rowan Darroch University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Xinlu Pan University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Eva A Rog-Zielinska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Wiktoria Wyrzykowska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Kathleen Scullion University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emad A S Al-Dujaili Dietetics, Nutrition, and Biological Sciences Department, Queen Margaret University, Musselburgh, UK

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Mary E Diaz University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Carmel M Moran University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Christopher J Kenyon University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Gillian A Gray University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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actions through the closely related glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). Cardiomyocytes lack the glucocorticoid-inactivating enzyme, 11β-hydroxysteroid dehydrogenase type 2 ( Chapman et al . 2013 ). Thus, the effects of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0458
Volume/Issue:
Volume 232: Issue 3
Open access
Eva M G Viho Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Jan Kroon Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA

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Richard A Feelders Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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René Houtman Precision Medicine Lab, Oss, the Netherlands

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Elisabeth S R van den Dungen Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Alberto M Pereira Department of Endocrinology and Metabolism, Amsterdam University Medical Center, Amsterdam, the Netherlands

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Hazel J Hunt Corcept Therapeutics, Menlo Park, CA, USA

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Leo J Hofland Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Onno C Meijer Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA

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Introduction Glucocorticoid (GC) stress hormones are essential for physiology and exert numerous functions via binding to the glucocorticoid receptor (GR). The predominant active GC hormone is cortisol in humans, while rats and mice adrenals

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0263
Volume/Issue:
Volume 256: Issue 2
Open access
Eugenie Macfarlane Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Hong Zhou Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Markus J Seibel Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia

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play a pivotal role in chronobiology by synchronising the body’s biological clocks and hence harmonising circadian rhythms across different organs and tissues. These diverse actions of glucocorticoids are mediated via the glucocorticoid receptor (GR

Article Type:
Review Article
Collections:
Endocrine Society of Australia special collection
DOI:
https://doi.org/10.1530/JOE-23-0399
Volume/Issue:
Volume 261: Issue 2
Restricted access
Lisa L Koorneef Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Jan Kroon Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Eva M G Viho Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Lucas F Wahl Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Kim M L Heckmans Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Marloes M A R van Dorst Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Menno Hoekstra Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands

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René Houtman Pamgene International, Den Bosch, The Netherlands

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Hazel Hunt Corcept Therapeutics, Menlo Park, California, USA

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Onno C Meijer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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. 2016 ). The most widely expressed GC receptor is the glucocorticoid receptor (GR), which mediates many effects on target tissues while simultaneously dampening HPA-axis activity via negative feedback loops at the level of the pituitary and the PVN

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0486
Volume/Issue:
Volume 246: Issue 1
Open access
Alberto Dinarello Department of Biology, University of Padova, Padova, Italy

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Giorgio Licciardello Department of Biology, University of Padova, Padova, Italy

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Camilla Maria Fontana Department of Biology, University of Padova, Padova, Italy

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Natascia Tiso Department of Biology, University of Padova, Padova, Italy

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Francesco Argenton Department of Biology, University of Padova, Padova, Italy

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Luisa Dalla Valle Department of Biology, University of Padova, Padova, Italy

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studies in D. rerio . Morpholino-induced knockdown of glucocorticoid receptors in zebrafish Zebrafish fertilization, being external, allows the microinjection of small antisense oligomers, called morpholinos (MOs), to transiently inhibit the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0173
Volume/Issue:
Volume 247: Issue 3
Free access
Kerryn M Taylor Division of Genetics, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa

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David W Ray Manchester Centre for Nuclear Hormone Research and Disease, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom

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Paula Sommer Division of Genetics, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa

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receptor Glucocorticoids (Gcs) are a class of steroid hormones that function to maintain homeostasis. The effects of Gcs are mediated by the ubiquitously expressed glucocorticoid receptor (GR), an intracellular ligand-activated transcription factor and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0496
Volume/Issue:
Volume 229: Issue 1
Free access
Ellen H Stolte Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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B M Lidy Verburg van Kemenade Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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Huub F J Savelkoul Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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Gert Flik Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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Introduction Glucocorticoids (GCs; cortisol and corticosterone) play a pivotal role in vertebrate physiology through a plethora of control mechanisms. The GC system, with a nuclear glucocorticoid receptor (GR), is found in all

Article Type:
Review Article
DOI:
https://doi.org/10.1677/joe.1.06703
Volume/Issue:
Volume 190: Issue 1
Free access
James S M Cuffe School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia
School of Biomedical Sciences, and Child Health Research Centre, The University of Queensland, St Lucia, Queensland, Australia
Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia

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Zarqa Saif Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia

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Anthony V Perkins School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia

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Karen M Moritz School of Biomedical Sciences, and Child Health Research Centre, The University of Queensland, St Lucia, Queensland, Australia

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Vicki L Clifton Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia

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glucocorticoid signaling through intricate interactions with steroid receptors is vital for healthy development. While natural glucocorticoids (cortisol and corticosterone) can bind to both the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0171
Volume/Issue:
Volume 234: Issue 2
Free access
Helen Garside Endocrine Sciences Research Group and Centre for Molecular Medicine, Faculty of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Molecular Medicine Unit, CSB, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, UK

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Charlotte Waters Endocrine Sciences Research Group and Centre for Molecular Medicine, Faculty of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Molecular Medicine Unit, CSB, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, UK

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Andy Berry Endocrine Sciences Research Group and Centre for Molecular Medicine, Faculty of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Molecular Medicine Unit, CSB, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, UK

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Lisa Rice Endocrine Sciences Research Group and Centre for Molecular Medicine, Faculty of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Molecular Medicine Unit, CSB, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, UK

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Helen C Ardley Endocrine Sciences Research Group and Centre for Molecular Medicine, Faculty of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Molecular Medicine Unit, CSB, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, UK

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Anne White Endocrine Sciences Research Group and Centre for Molecular Medicine, Faculty of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Molecular Medicine Unit, CSB, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, UK

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Philip A Robinson Endocrine Sciences Research Group and Centre for Molecular Medicine, Faculty of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Molecular Medicine Unit, CSB, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, UK

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David Ray Endocrine Sciences Research Group and Centre for Molecular Medicine, Faculty of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Molecular Medicine Unit, CSB, St. James’s University Hospital, University of Leeds, Leeds LS9 7TF, UK

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Introduction The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily. It is a key regulator of many homeostatic mechanisms and is also the target of therapeutic glucocorticoids used to treat inflammatory

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06799
Volume/Issue:
Volume 190: Issue 3
Free access