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Mathis Grossmann

70 years of clinical experience. On the other hand, in functional androgen deficiency due to axis suppression because of age-related comorbidities, treatment may aim for a specific health outcome, such as improvement of glucose metabolism, and

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Yu Wu, Tingting Wu, Jun Wu, Lei Zhao, Qing Li, Zac Varghese, John F Moorhead, Stephen H Powis, Yaxi Chen and Xiong Z Ruan

aggravated insulin resistance and glucose metabolism disorders in HFD-fed C57BL/6J mice The fasting glucose levels were unchanged in HFD-fed mice compared with NCD-fed mice ( Fig. 2 A and C). After glucose challenge, blood glucose concentration of HFD group

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Haijiang Wu, Xinna Deng, Yonghong Shi, Ye Su, Jinying Wei and Huijun Duan

therapy. In this review, we summarize the major findings on the function of PGC-1α in glucose metabolism and discuss its potential therapeutic applications for T2DM. The close correlation between PGC-1α polymorphisms and T2DM is also discussed in this

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Lars P Klieverik, Ewout Foppen, Mariëtte T Ackermans, Mireille J Serlie, Hans P Sauerwein, Thomas S Scanlan, David K Grandy, Eric Fliers and Andries Kalsbeek

hypothalamus, regulates most of the processes affected by thyronamines (body temperature, cardiac function, and energy metabolism). Moreover, a principal role in regulating hepatic glucose metabolism has recently emerged for the hypothalamus ( Obici et al

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Kanta Kon, Hiroshi Tsuneki, Hisakatsu Ito, Yoshinori Takemura, Kiyofumi Sato, Mitsuaki Yamazaki, Yoko Ishii, Masakiyo Sasahara, Assaf Rudich, Takahiro Maeda, Tsutomu Wada and Toshiyasu Sasaoka

and behavioral circadian misalignments in modern lifestyle, such as shift work and late eating, lead to dysregulation of glucose metabolism and increased risk of type 2 diabetes ( Cedernaes et al. 2015 , Qian et al. 2016 ). Intriguingly, one night

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K L Franko, A J Forhead and A L Fowden

, little is known about the effects of commonly used control procedures, such as maternal saline or vehicle injection, on glucose metabolism of their offspring. The current study, therefore, compared the effects of maternal injection with dex or saline with

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S Patterson, P R Flatt, L Brennan, P Newsholme and N H McClenaghan

.p.m.) and the supernatant was treated with Chelex-100 resin and then lyophilised. Assessment of glucose metabolism by NMR spectroscopy The lyophilised cell extracts were dissolved in 3 ml H 2 O and then centrifuged at 1500

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B Maiztegui, M I Borelli, M A Raschia, H Del Zotto and J J Gagliardino

. 2003 ). Evidence in the literature has shown that glucokinase (GK) activity plays a pivotal role upon islet glucose metabolism and insulin secretion. As opposed to other hexokinases (HK), GK kinetics shows a cooperative glucose dependence (Hill

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Anthony Raffo, Kolbe Hancock, Teresa Polito, Yuli Xie, Gordon Andan, Piotr Witkowski, Mark Hardy, Pasquale Barba, Caterina Ferrara, Antonella Maffei, Matthew Freeby, Robin Goland, Rudolph L Leibel, Ian R Sweet and Paul E Harris

tissue and β-cells, in glucose metabolism has not yet been explored. As indicated, endogenously synthesized and/or stored monoamine neurotransmitters appear to participate in the paracrine regulation of insulin secretion and entrainment of the activity of

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Corinne Caillaud, Mie Mechta, Heidi Ainge, Andreas N Madsen, Patricia Ruell, Emilie Mas, Catherine Bisbal, Jacques Mercier, Stephen Twigg, Trevor A Mori, David Simar and Romain Barrès

as a regulator involved in glucose metabolism. Results of early studies carried out of patients with end-stage renal disease (ESRD) indicated that EPO not only treated anemia but also improved insulin sensitivity ( Borissova et al . 1993 , Mak 1996